| Towards the sustainable discovery and development of new antibiotics M Miethke, M Pieroni, T Weber, M Brönstrup, P Hammann, L Halby, ... Nature Reviews Chemistry 5 (10), 726-749, 2021 | 575 | 2021 |
| The triple helix: 50 years later, the outcome M Duca, P Vekhoff, K Oussedik, L Halby, PB Arimondo Nucleic acids research 36 (16), 5123-5138, 2008 | 406 | 2008 |
| DNA methylation inhibitors in cancer: recent and future approaches C Gros, J Fahy, L Halby, I Dufau, A Erdmann, JM Gregoire, F Ausseil, ... Biochimie 94 (11), 2280-2296, 2012 | 277 | 2012 |
| DNA methylation targeting: the DNMT/HMT crosstalk challenge O Castillo-Aguilera, P Depreux, L Halby, PB Arimondo, L Goossens Biomolecules 7 (1), 3, 2017 | 142 | 2017 |
| Targeting DNA methylation with small molecules: what’s next? Miniperspective A Erdmann, L Halby, J Fahy, PB Arimondo Journal of medicinal chemistry 58 (6), 2569-2583, 2015 | 139 | 2015 |
| Exploring the cellular activity of camptothecin-triple-helix-forming oligonucleotide conjugates PB Arimondo, CJ Thomas, K Oussedik, B Baldeyrou, C Mahieu, L Halby, ... Molecular and cellular biology 26 (1), 324-333, 2006 | 92 | 2006 |
| Rapid synthesis of new DNMT inhibitors derivatives of procainamide L Halby, C Champion, C Sénamaud‐Beaufort, S Ajjan, T Drujon, ... Chembiochem 13 (1), 157-165, 2012 | 74 | 2012 |
| Rational design of bisubstrate-type analogues as inhibitors of DNA methyltransferases in cancer cells L Halby, Y Menon, E Rilova, D Pechalrieu, V Masson, C Faux, MA Bouhlel, ... Journal of Medicinal Chemistry 60 (11), 4665-4679, 2017 | 47 | 2017 |
| Sequence‐Specific Conjugates of Oligo(2′‐O‐methylribonucleotides) and Hairpin Oligocarboxamide Minor‐Groove Binders: Design, Synthesis, and Binding … DS Novopashina, AN Sinyakov, VA Ryabinin, AG Venyaminova, L Halby, ... Chemistry & Biodiversity 2 (7), 936-952, 2005 | 45 | 2005 |
| Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides M Duca, D Guianvarc'h, K Oussedik, L Halby, A Garbesi, D Dauzonne, ... Nucleic acids research 34 (6), 1900-1911, 2006 | 41 | 2006 |
| Sequence-specific DNA cleavage mediated by bipyridine polyamide conjugates P Simon, F Cannata, L Perrouault, L Halby, JP Concordet, A Boutorine, ... Nucleic acids research 36 (11), 3531-3538, 2008 | 37 | 2008 |
| DNA methyltransferase inhibitors: development and applications M Lopez, L Halby, PB Arimondo DNA Methyltransferases-Role and Function, 431-473, 2016 | 33 | 2016 |
| Functionalized head-to-head hairpin polyamides: Synthesis, double-stranded DNA-binding activity and affinity L Halby, VA Ryabinin, AN Sinyakov, AS Boutorine Bioorganic & medicinal chemistry letters 15 (16), 3720-3724, 2005 | 33 | 2005 |
| The past and presence of gene targeting: from chemicals and DNA via proteins to RNA TM Geel, MHJ Ruiters, RH Cool, L Halby, DC Voshart, L Andrade Ruiz, ... Philosophical Transactions of the Royal Society B: Biological Sciences 373 …, 2018 | 29 | 2018 |
| Design and synthesis of new non nucleoside inhibitors of DNMT3A A Erdmann, Y Menon, C Gros, N Molinier, N Novosad, A Samson, ... Bioorganic & Medicinal Chemistry 23 (17), 5946-5953, 2015 | 29 | 2015 |
| DNA Methylation Bisubstrate Inhibitors Are Fast-Acting Drugs Active against Artemisinin-Resistant Plasmodium falciparum Parasites F Nardella, L Halby, E Hammam, D Erdmann, V Cadet-Daniel, R Peronet, ... ACS central science 6 (1), 16-21, 2019 | 28 | 2019 |
| Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors L Halby, N Marechal, D Pechalrieu, V Cura, DM Franchini, C Faux, F Alby, ... Philosophical Transactions of the Royal Society B: Biological Sciences 373 …, 2018 | 25 | 2018 |
| Single-molecule observations of topotecan-mediated TopIB activity at a unique DNA sequence DA Koster, F Czerwinski, L Halby, A Crut, P Vekhoff, K Palle, PB Arimondo, ... Nucleic acids research 36 (7), 2301-2310, 2008 | 22 | 2008 |
| Sequence-specific targeting of IGF-I and IGF-IR genes by camptothecins K Oussedik, JC François, L Halby, C Senamaud-Beaufort, G Toutirais, ... The FASEB Journal 24 (7), 2235, 2010 | 20 | 2010 |
| Activation of camptothecin derivatives by conjugation to triple helix-forming oligonucleotides PB Arimondo, GS Laco, CJ Thomas, L Halby, D Pez, P Schmitt, ... Biochemistry 44 (11), 4171-4180, 2005 | 20 | 2005 |
