OSPREY 3.0: Open‐source protein redesign for you, with powerful new features MA Hallen, JW Martin, A Ojewole, JD Jou, AU Lowegard, MS Frenkel, ...
Journal of computational chemistry 39 (30), 2494-2507, 2018
67 2018 Early computational detection of potential high-risk SARS-CoV-2 variants K Beguir, MJ Skwark, Y Fu, T Pierrot, NL Carranza, A Laterre, I Kadri, ...
Computers in biology and medicine 155, 106618, 2023
27 2023 OSPREY predicts resistance mutations using positive and negative computational protein design A Ojewole, A Lowegard, P Gainza, SM Reeve, I Georgiev, AC Anderson, ...
Computational Protein Design, 291-306, 2017
17 2017 Novel, provable algorithms for efficient ensemble-based computational protein design and their application to the redesign of the c-Raf-RBD: KRas protein-protein interface AU Lowegard, MS Frenkel, GT Holt, JD Jou, AA Ojewole, BR Donald
PLoS Computational Biology 16 (6), e1007447, 2020
13 2020 Computational analysis of energy landscapes reveals dynamic features that contribute to binding of inhibitors to CFTR-associated ligand GT Holt, JD Jou, NP Gill, AU Lowegard, JW Martin, DR Madden, ...
The Journal of Physical Chemistry B 123 (49), 10441-10455, 2019
9 2019 Minimization-Aware Recursive K*: A Novel, Provable Algorithm that Accelerates Ensemble-Based Protein Design and Provably Approximates the Energy Landscape JD Jou, GT Holt, AU Lowegard, BR Donald
Journal of Computational Biology 27 (4), 550-564, 2020
8 2020 Minimization-Aware Recursive ( ): A Novel, Provable Algorithm that Accelerates Ensemble-Based Protein Design and Provably Approximates the Energy … JD Jou, GT Holt, AU Lowegard, BR Donald
Research in Computational Molecular Biology: 23rd Annual International …, 2019
3 2019 Improved HIV-1 neutralization breadth and potency of V2-apex antibodies by in silico design GT Holt, J Gorman, S Wang, AU Lowegard, B Zhang, T Liu, BC Lin, ...
Cell reports 42 (7), 2023
2 2023 Compositions for inhibiting kras signaling and methods of making and using same B Donald, A Lowegard, M Frenkel
US Patent App. 17/332,338, 2021
2021 Supplementary Information: Minimization-Aware Recursive K (MARK): A Novel, Provable Algorithm that Accelerates Ensemble-based Protein Design and Provably Approximates the … JD Jou, GT Holt, AU Lowegard, BR Donald
2019 Novel Algorithms and Tools for Computational Protein Design with Applications to Drug Resistance Prediction, Antibody Design, Peptide Inhibitor Design, and Protein Stability … AU Lowegard
Duke University, 2019
2019 Predicting the Effect of Mutations in the KRas/c-Raf-RBD Protein-Protein Interface A Lowegard, M Frenkel, B Donald
Biophysical Journal 114 (3), 576a, 2018
2018 How we responded to reviewers’ comments: Novel, Provable Algorithms for Efficient Ensemble-Based Computational Protein Design and Their Application to the Redesign of the c-Raf … AU Lowegard, MS Frenkel, GT Holt, JD Jou, AA Ojewole, BR Donald