|A community effort to assess and improve drug sensitivity prediction algorithms|
JC Costello, LM Heiser, E Georgii, M Gönen, MP Menden, NJ Wang, ...
Nature biotechnology 32 (12), 1202-1212, 2014
|Subtype and pathway specific responses to anticancer compounds in breast cancer|
LM Heiser, A Sadanandam, WL Kuo, SC Benz, TC Goldstein, S Ng, ...
Proceedings of the National Academy of Sciences 109 (8), 2724-2729, 2012
|Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition|
OK Mirzoeva, D Das, LM Heiser, S Bhattacharya, D Siwak, R Gendelman, ...
Cancer research 69 (2), 565-572, 2009
|Metrics other than potency reveal systematic variation in responses to cancer drugs|
M Fallahi-Sichani, S Honarnejad, LM Heiser, JW Gray, PK Sorger
Nature chemical biology 9 (11), 708, 2013
|Modeling precision treatment of breast cancer|
A Daemen, OL Griffith, LM Heiser, NJ Wang, OM Enache, Z Sanborn, ...
Genome biology 14 (10), R110, 2013
|A central role for RAF→ MEK→ ERK signaling in the genesis of pancreatic ductal adenocarcinoma|
EA Collisson, CL Trejo, JM Silva, S Gu, JE Korkola, LM Heiser, ...
Cancer discovery 2 (8), 685-693, 2012
|A community computational challenge to predict the activity of pairs of compounds|
M Bansal, J Yang, C Karan, MP Menden, JC Costello, H Tang, G Xiao, ...
Nature biotechnology 32 (12), 1213-1222, 2014
|Inferring causal molecular networks: empirical assessment through a community-based effort|
SM Hill, LM Heiser, T Cokelaer, M Unger, NK Nesser, DE Carlin, Y Zhang, ...
Nature methods 13 (4), 310-318, 2016
|Tumor-derived Cell Lines as Molecular Models of Cancer Pharmacogenomics|
A Goodspeed, LM Heiser, JW Gray, JC Costello
Molecular Cancer Research 14 (1), 3-13, 2016
|The library of integrated network-based cellular signatures NIH program: system-level cataloging of human cells response to perturbations|
AB Keenan, SL Jenkins, KM Jagodnik, S Koplev, E He, D Torre, Z Wang, ...
Cell systems, 2017
|Bayesian inference of signaling network topology in a cancer cell line|
SM Hill, Y Lu, J Molina, LM Heiser, PT Spellman, TP Speed, JW Gray, ...
Bioinformatics 28 (21), 2804-2810, 2012
|Spatial updating in area LIP is independent of saccade direction|
LM Heiser, CL Colby
Journal of neurophysiology 95 (5), 2751-2767, 2006
|Analysis of molecular inversion probe performance for allele copy number determination|
Y Wang, M Moorhead, G Karlin-Neumann, NJ Wang, J Ireland, S Lin, ...
Genome biology 8 (11), 1-14, 2007
|Integrated analysis of breast cancer cell lines reveals unique signaling pathways|
LM Heiser, NJ Wang, CL Talcott, KR Laderoute, M Knapp, Y Guan, Z Hu, ...
Genome Biol 10 (3), R31, 2009
|FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer|
X Fu, R Jeselsohn, R Pereira, EF Hollingsworth, CJ Creighton, F Li, ...
Proceedings of the National Academy of Sciences, 201612835, 2016
|Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or …|
X Fu, CJ Creighton, NC Biswal, V Kumar, M Shea, S Herrera, A Contreras, ...
Breast Cancer Research 16 (5), 430, 2014
|LSD1 activates a lethal prostate cancer gene network independently of its demethylase function|
A Sehrawat, L Gao, Y Wang, A Bankhead, SK McWeeney, CJ King, ...
Proceedings of the National Academy of Sciences, 201719168, 2018
|Dynamic circuitry for updating spatial representations. I. Behavioral evidence for interhemispheric transfer in the split-brain macaque|
RA Berman, LM Heiser, RC Saunders, CL Colby
Journal of neurophysiology 94 (5), 3228-3248, 2005
|Upregulation of ER signaling as an adaptive mechanism of cell survival in HER2-positive breast tumors treated with anti-HER2 therapy|
M Giuliano, H Hu, YC Wang, X Fu, A Nardone, S Herrera, S Mao, ...
Clinical Cancer Research 21 (17), 3995-4003, 2015
|Combating subclonal evolution of resistant cancer phenotypes|
SW Brady, JA McQuerry, Y Qiao, SR Piccolo, G Shrestha, DF Jenkins, ...
Nature communications 8 (1), 1231, 2017