| Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy RD Sentelle, CE Senkal, W Jiang, S Ponnusamy, S Gencer, ... Nature chemical biology 8 (10), 831-838, 2012 | 532 | 2012 |
| Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance S Ponnusamy, M Meyers-Needham, CE Senkal, SA Saddoughi, ... Future oncology 6 (10), 1603-1624, 2010 | 361 | 2010 |
| Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A‐RIPK1‐dependent necroptosis SA Saddoughi, S Gencer, YK Peterson, KE Ward, A Mukhopadhyay, ... EMBO molecular medicine 5 (1), 105-121, 2013 | 293 | 2013 |
| Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways CE Senkal, S Ponnusamy, J Bielawski, YA Hannun, B Ogretmen The FASEB Journal 24 (1), 296, 2010 | 273 | 2010 |
| Defects in cell growth regulation by C18: 0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas S Koybasi, CE Senkal, K Sundararaj, S Spassieva, J Bielawski, W Osta, ... Journal of Biological Chemistry 279 (43), 44311-44319, 2004 | 270 | 2004 |
| Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells Y Baran, A Salas, CE Senkal, U Gunduz, J Bielawski, LM Obeid, ... Journal of Biological Chemistry 282 (15), 10922-10934, 2007 | 267 | 2007 |
| Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling A Mukhopadhyay, SA Saddoughi, P Song, I Sultan, S Ponnusamy, ... The FASEB Journal 23 (3), 751, 2009 | 248 | 2009 |
| Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): Attenuation of C18-ceramide in HNSCC tumors correlates … S Karahatay, K Thomas, S Koybasi, CE Senkal, S ElOjeimy, X Liu, ... Cancer letters 256 (1), 101-111, 2007 | 223 | 2007 |
| Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas CE Senkal, S Ponnusamy, MJ Rossi, J Bialewski, D Sinha, JC Jiang, ... Molecular cancer therapeutics 6 (2), 712-722, 2007 | 198 | 2007 |
| Ceramide is metabolized to acylceramide and stored in lipid droplets CE Senkal, MF Salama, AJ Snider, JJ Allopenna, NA Rana, A Koller, ... Cell metabolism 25 (3), 686-697, 2017 | 191 | 2017 |
| Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells S White-Gilbertson, T Mullen, C Senkal, P Lu, B Ogretmen, L Obeid, ... Oncogene 28 (8), 1132-1141, 2009 | 185 | 2009 |
| Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A A Salas, S Ponnusamy, CE Senkal, M Meyers-Needham, SP Selvam, ... Blood, The Journal of the American Society of Hematology 117 (22), 5941-5952, 2011 | 150 | 2011 |
| Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular … CE Senkal, S Ponnusamy, Y Manevich, M Meyers-Needham, ... Journal of Biological Chemistry 286 (49), 42446-42458, 2011 | 129 | 2011 |
| Sphingolipids in mitochondria MJ Hernández-Corbacho, MF Salama, D Canals, CE Senkal, LM Obeid Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2017 | 121 | 2017 |
| Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo CE Senkal, S Ponnusamy, MJ Rossi, K Sundararaj, Z Szulc, J Bielawski, ... Journal of Pharmacology and Experimental Therapeutics 317 (3), 1188-1199, 2006 | 100 | 2006 |
| Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation MV Airola, P Shanbhogue, AA Shamseddine, KE Guja, CE Senkal, ... Proceedings of the National Academy of Sciences 114 (28), E5549-E5558, 2017 | 90 | 2017 |
| Mechanisms of ceramide‐mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1 LG Wooten‐Blanks, P Song, CE Senkal, B Ogretmen The FASEB Journal 21 (12), 3386-3397, 2007 | 85 | 2007 |
| TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis S Gencer, N Oleinik, J Kim, S Panneer Selvam, R De Palma, M Dany, ... Science signaling 10 (502), eaam7464, 2017 | 82 | 2017 |
| Results of a Phase II Trial of Gemcitabine Plus Doxorubicin in Patients with Recurrent Head and Neck Cancers: Serum C18-Ceramide as a Novel Biomarker for … SA Saddoughi, E Garrett-Mayer, U Chaudhary, PE O'Brien, LB Afrin, ... Clinical Cancer Research 17 (18), 6097-6105, 2011 | 78 | 2011 |
| Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK K Kitatani, J Idkowiak-Baldys, J Bielawski, TA Taha, RW Jenkins, ... Journal of biological chemistry 281 (48), 36793-36802, 2006 | 77 | 2006 |
