| The janus kinases (jaks) K Yamaoka, P Saharinen, M Pesu, VET Holt, O Silvennoinen, JJ O'Shea Genome biology 5, 1-6, 2004 | 780 | 2004 |
| Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation P Saharinen, T Tammela, MJ Karkkainen, K Alitalo Trends in immunology 25 (7), 387-395, 2004 | 587 | 2004 |
| Signaling and functions of angiopoietin-1 in vascular protection NPJ Brindle, P Saharinen, K Alitalo Circulation research 98 (8), 1014-1023, 2006 | 550 | 2006 |
| Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts P Saharinen, L Eklund, J Miettinen, R Wirkkala, A Anisimov, M Winderlich, ... Nature cell biology 10 (5), 527-537, 2008 | 539 | 2008 |
| VEGF and angiopoietin signaling in tumor angiogenesis and metastasis P Saharinen, L Eklund, K Pulkki, P Bono, K Alitalo Trends in molecular medicine 17 (7), 347-362, 2011 | 537 | 2011 |
| Regulation of the Jak2 tyrosine kinase by its pseudokinase domain P Saharinen, K Takaluoma, O Silvennoinen Molecular and cellular biology 20 (10), 3387-3395, 2000 | 494 | 2000 |
| Therapeutic targeting of the angiopoietin–TIE pathway P Saharinen, L Eklund, K Alitalo Nature Reviews Drug Discovery 16 (9), 635-661, 2017 | 439 | 2017 |
| The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction P Saharinen, O Silvennoinen Journal of Biological Chemistry 277 (49), 47954-47963, 2002 | 403 | 2002 |
| Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1 D Ungureanu, P Saharinen, I Junttila, DJ Hilton, O Silvennoinen Molecular and cellular biology, 2002 | 363 | 2002 |
| Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2 P Saharinen, K Kerkelä, N Ekman, M Marron, N Brindle, GM Lee, ... The Journal of cell biology 169 (2), 239-243, 2005 | 299 | 2005 |
| Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain P Saharinen, M Vihinen, O Silvennoinen Molecular biology of the cell 14 (4), 1448-1459, 2003 | 297 | 2003 |
| Angiopoietin signaling in the vasculature L Eklund, P Saharinen Experimental cell research 319 (9), 1271-1280, 2013 | 279 | 2013 |
| Endothelial destabilization by angiopoietin-2 via integrin β1 activation L Hakanpaa, T Sipila, VM Leppanen, P Gautam, H Nurmi, G Jacquemet, ... Nature communications 6 (1), 5962, 2015 | 270 | 2015 |
| Tie1 controls angiopoietin function in vascular remodeling and inflammation EA Korhonen, A Lampinen, H Giri, A Anisimov, M Kim, B Allen, S Fang, ... The Journal of clinical investigation 126 (9), 3495-3510, 2016 | 239 | 2016 |
| Effects of angiopoietin-2-blocking antibody on endothelial cell–cell junctions and lung metastasis T Holopainen, P Saharinen, G D’Amico, A Lampinen, L Eklund, ... Journal of the National Cancer Institute 104 (6), 461-475, 2012 | 235 | 2012 |
| The Schlemm’s canal is a VEGF-C/VEGFR-3–responsive lymphatic-like vessel A Aspelund, T Tammela, S Antila, H Nurmi, VM Leppänen, G Zarkada, ... The Journal of clinical investigation 124 (9), 3975-3986, 2014 | 216 | 2014 |
| Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation M Kim, B Allen, EA Korhonen, M Nitschké, HW Yang, P Baluk, ... The Journal of clinical investigation 126 (9), 3511-3525, 2016 | 209 | 2016 |
| The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis HI Chen, B Sharma, BN Akerberg, HJ Numi, R Kivelä, P Saharinen, ... Development 141 (23), 4500-4512, 2014 | 207 | 2014 |
| Receptor tyrosine kinase-mediated angiogenesis M Jeltsch, VM Leppänen, P Saharinen, K Alitalo Cold Spring Harbor perspectives in biology 5 (9), a009183, 2013 | 195 | 2013 |
| Angiopoietin–Tie signalling in the cardiovascular and lymphatic systems L Eklund, J Kangas, P Saharinen Clinical Science 131 (1), 87-103, 2017 | 194 | 2017 |
