| An improved zinc-finger nuclease architecture for highly specific genome editing JC Miller, MC Holmes, J Wang, DY Guschin, YL Lee, I Rupniewski, ... Nature biotechnology 25 (7), 778-785, 2007 | 1490 | 2007 |
| Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases EE Perez, J Wang, JC Miller, Y Jouvenot, KA Kim, O Liu, N Wang, G Lee, ... Nature biotechnology 26 (7), 808-816, 2008 | 1381 | 2008 |
| The protein tyrosine kinase JAK1 complements defects in interferon-α/β and-γ signal transduction M Müller, J Briscoe, C Laxton, D Guschin, A Ziemiecki, O Silvennoinen, ... Nature 366 (6451), 129-135, 1993 | 937 | 1993 |
| Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations F Soldner, J Laganière, AW Cheng, D Hockemeyer, Q Gao, R Alagappan, ... Cell 146 (2), 318-331, 2011 | 926 | 2011 |
| DNA analysis and diagnostics on oligonucleotide microchips. G Yershov, V Barsky, A Belgovskiy, E Kirillov, E Kreindlin, I Ivanov, ... Proceedings of the National Academy of Sciences 93 (10), 4913-4918, 1996 | 733 | 1996 |
| A rapid and general assay for monitoring endogenous gene modification DY Guschin, AJ Waite, GE Katibah, JC Miller, MC Holmes, EJ Rebar Engineered Zinc Finger Proteins: Methods and Protocols, 247-256, 2010 | 664 | 2010 |
| Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway D Watling, D Guschin, M Müller, O Silvennoinen, BA Witthuhn, FW Quelle, ... Nature 366 (6451), 166-170, 1993 | 619 | 1993 |
| A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin‐6. D Guschin, N Rogers, J Briscoe, B Witthuhn, D Watling, F Horn, ... The EMBO journal 14 (7), 1421-1429, 1995 | 615 | 1995 |
| Oligonucleotide microchips as genosensors for determinative and environmental studies in microbiology DY Guschin, BK Mobarry, D Proudnikov, DA Stahl, BE Rittmann, ... Applied and environmental microbiology 63 (6), 2397-2402, 1997 | 501 | 1997 |
| Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases Y Santiago, E Chan, PQ Liu, S Orlando, L Zhang, FD Urnov, MC Holmes, ... Proceedings of the National Academy of Sciences 105 (15), 5809-5814, 2008 | 485 | 2008 |
| Chromatin structural features and targets that regulate transcription AP Wolffe, D Guschin Journal of structural biology 129 (2-3), 102-122, 2000 | 478 | 2000 |
| Manual manufacturing of oligonucleotide, DNA, and protein microchips D Guschin, G Yershov, A Zaslavsky, A Gemmell, V Shick, D Proudnikov, ... Analytical biochemistry 250 (2), 203-211, 1997 | 433 | 1997 |
| Translating dosage compensation to trisomy 21 J Jiang, Y Jing, GJ Cost, JC Chiang, HJ Kolpa, AM Cotton, DM Carone, ... Nature 500 (7462), 296-300, 2013 | 409 | 2013 |
| Targeted deletion of cellular DNA sequences D Guschin, MC Holmes US Patent 8,409,861, 2013 | 392 | 2013 |
| Change in the pattern of histone binding to DNA upon transcriptional activation GA Nacheva, DY Guschin, OV Preobrazhenskaya, VL Karpov, ... Cell 58 (1), 27-36, 1989 | 296 | 1989 |
| Active remodeling of somatic nuclei in egg cytoplasm by the nucleosomal ATPase ISWI N Kikyo, PA Wade, D Guschin, H Ge, AP Wolffe Science 289 (5488), 2360-2362, 2000 | 273 | 2000 |
| A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses FK Kohlhuber, NC Rogers, D Watling, J Feng, D Guschin, J Briscoe, ... Molecular and cellular biology 17 (2), 695-706, 1997 | 266 | 1997 |
| Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity S Tan, D Guschin, A Davalos, YL Lee, AW Snowden, Y Jouvenot, ... Proceedings of the National Academy of Sciences 100 (21), 11997-12002, 2003 | 265 | 2003 |
| Targeted genomic modification with partially single-stranded donor molecules GJ Cost, DM Guschin, F Urnov US Patent 9,255,259, 2016 | 264 | 2016 |
| Activation of JAK kinases and STAT proteins by interleukin‐2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes. C Beadling, D Guschin, BA Witthuhn, A Ziemiecki, JN Ihle, IM Kerr, ... The EMBO journal 13 (23), 5605-5615, 1994 | 262 | 1994 |
Philip D. GregoryChief Scientific OfficerVerified email at bluebirdbio.com
