Sébastien AUGUSTIN
Sébastien AUGUSTIN
Institut de la Vision - UPMC
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Optimized allotopic expression of the human mitochondrial ND4 prevents blindness in a rat model of mitochondrial dysfunction
S Ellouze, S Augustin, A Bouaita, C Bonnet, M Simonutti, V Forster, ...
The American Journal of Human Genetics 83 (3), 373-387, 2008
Complement factor H inhibits CD47-mediated resolution of inflammation
B Calippe, S Augustin, F Beguier, H Charles-Messance, L Poupel, ...
Immunity 46 (2), 261-272, 2017
The optimized allotopic expression of ND1 or ND4 genes restores respiratory chain complex I activity in fibroblasts harboring mutations in these genes
C Bonnet, S Augustin, S Ellouze, P Bénit, A Bouaita, P Rustin, JA Sahel, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1783 (10), 1707-1717, 2008
Allotopic mRNA localization to the mitochondrial surface rescues respiratory chain defects in fibroblasts harboring mitochondrial DNA mutations affecting complex I or v subunits
C Bonnet, V Kaltimbacher, S Ellouze, S Augustin, P Bénit, V Forster, ...
Rejuvenation research 10 (2), 127-144, 2007
Subretinal mononuclear phagocytes induce cone segment loss via IL-1β
CM Eandi, H Charles Messance, S Augustin, E Dominguez, S Lavalette, ...
Elife 5, e16490, 2016
Neuroglobin involvement in respiratory chain function and retinal ganglion cell integrity
C Lechauve, S Augustin, H Cwerman-Thibault, A Bouaita, V Forster, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1823 (12), 2261-2273, 2012
Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss
H Cwerman-Thibault, S Augustin, C Lechauve, J Ayache, S Ellouze, ...
Molecular Therapy Methods & Clinical Development 2, 2015
Gene therapy for mitochondrial diseases: Leber Hereditary Optic Neuropathy as the first candidate for a clinical trial
H Cwerman-Thibault, S Augustin, S Ellouze, JA Sahel, M Corral-Debrinski
Comptes rendus biologies 337 (3), 193-206, 2014
The 10q26 risk haplotype of age-related macular degeneration aggravates subretinal inflammation by impairing monocyte elimination
F Beguier, M Housset, C Roubeix, S Augustin, Y Zagar, C Nous, T Mathis, ...
Immunity 53 (2), 429-441. e8, 2020
ANGPTL4–αvβ3 interaction counteracts hypoxia‐induced vascular permeability by modulating Src signalling downstream of vascular endothelial growth factor receptor 2
E Gomez Perdiguero, A Liabotis‐Fontugne, M Durand, C Faye, ...
The Journal of Pathology 240 (4), 461-471, 2016
Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX 2 expression via TNF‐α
T Mathis, M Housset, C Eandi, F Beguier, S Touhami, S Reichman, ...
Aging Cell 16 (1), 173-182, 2017
Foxg1-Cre mediated Lrp2 inactivation in the developing mouse neural retina, ciliary and retinal pigment epithelia models congenital high myopia
O Cases, A Joseph, A Obry, MD Santin, S Ben-Yacoub, M Pâques, ...
PloS one 10 (6), e0129518, 2015
In vivo observation of the locomotion of microglial cells in the retina
M Paques, M Simonutti, S Augustin, O Goupille, B El Mathari, JA Sahel
Glia 58 (14), 1663-1668, 2010
Neuroglobin involvement in visual pathways through the optic nerve
C Lechauve, S Augustin, D Roussel, JA Sahel, M Corral-Debrinski
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1834 (9), 1772-1778, 2013
Downregulation of apoptosis-inducing factor in Harlequin mice induces progressive and severe optic atrophy which is durably prevented by AAV2-AIF1 gene therapy
A Bouaita, S Augustin, C Lechauve, H Cwerman-Thibault, P Bénit, ...
Brain 135 (1), 35-52, 2012
Neuroglobin can prevent or reverse glaucomatous progression in DBA/2J mice
H Cwerman-Thibault, C Lechauve, S Augustin, D Roussel, É Reboussin, ...
Molecular therapy Methods & clinical development 5, 200-220, 2017
Matrix metalloproteinases are involved in both type I (apoptosis) and type II (autophagy) cell death induced by sodium phenylacetate in MDA-MB-231 breast tumour cells
S Augustin, M Berard, S Kellaf, N Peyri, F Fauvel-Lafeve, C Legrand, ...
Anticancer research 29 (4), 1335-1343, 2009
Neuroglobin gene therapy prevents optic atrophy and preserves durably visual function in Harlequin mice
C Lechauve, S Augustin, H Cwerman-Thibault, É Reboussin, D Roussel, ...
Molecular Therapy 22 (6), 1096-1109, 2014
IL-1β induces rod degeneration through the disruption of retinal glutamate homeostasis
H Charles-Messance, G Blot, A Couturier, L Vignaud, S Touhami, ...
Journal of neuroinflammation 17, 1-12, 2020
Chronic exposure to tumor necrosis factor alpha induces retinal pigment epithelium cell dedifferentiation
S Touhami, F Beguier, S Augustin, H Charles-Messance, L Vignaud, ...
Journal of neuroinflammation 15, 1-11, 2018
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