Suivre
Manu Sharma
Manu Sharma
Assistant Professor of Neuroscience, Weill Cornell Medical College
Adresse e-mail validée de med.cornell.edu
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Année
α-Synuclein promotes SNARE-complex assembly in vivo and in vitro
J Burré, M Sharma, T Tsetsenis, V Buchman, MR Etherton, TC Südhof
Science 329 (5999), 1663-1667, 2010
20782010
α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation
J Burré, M Sharma, TC Südhof
Proceedings of the National Academy of Sciences 111 (40), E4274-E4283, 2014
5252014
Cell biology and pathophysiology of α-synuclein
J Burré, M Sharma, TC Südhof
Cold Spring Harbor perspectives in medicine 8 (3), a024091, 2018
5212018
The ΔF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR
K Du, M Sharma, GL Lukacs
Nature structural & molecular biology 12 (1), 17-25, 2005
4202005
Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes
M Sharma, F Pampinella, C Nemes, M Benharouga, J So, K Du, ...
The Journal of cell biology 164 (6), 923-933, 2004
3992004
Properties of native brain α-synuclein
J Burré, S Vivona, J Diao, M Sharma, AT Brunger, TC Südhof
Nature 498 (7453), E4-E6, 2013
3912013
Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2
J Diao, J Burré, S Vivona, DJ Cipriano, M Sharma, M Kyoung, TC Südhof, ...
elife 2, e00592, 2013
3802013
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function
M Etherton, C Földy, M Sharma, K Tabuchi, X Liu, M Shamloo, ...
Proceedings of the National Academy of Sciences 108 (33), 13764-13769, 2011
3662011
CASK Functions as a Mg2+-independent neurexin kinase
K Mukherjee, M Sharma, H Urlaub, GP Bourenkov, R Jahn, TC Südhof, ...
Cell 133 (2), 328-339, 2008
3102008
The complexity of tau in Alzheimer’s disease
NN Naseri, H Wang, J Guo, M Sharma, W Luo
Neuroscience letters 705, 183-194, 2019
3012019
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity
M Sharma, J Burré, TC Südhof
Nature cell biology 13 (1), 30-39, 2011
2942011
Conformational and temperature-sensitive stability defects of the ΔF508 cystic fibrosis transmembrane conductance regulator in post-endoplasmic reticulum compartments
M Sharma, M Benharouga, W Hu, GL Lukacs
Journal of Biological Chemistry 276 (12), 8942-8950, 2001
2672001
Definition of a molecular pathway mediating α-synuclein neurotoxicity
J Burré, M Sharma, TC Südhof
Journal of Neuroscience 35 (13), 5221-5232, 2015
2242015
Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities
J Burré, M Sharma, TC Südhof
Journal of Neuroscience 32 (43), 15227-15242, 2012
2092012
CSPα knockout causes neurodegeneration by impairing SNAP‐25 function
M Sharma, J Burré, P Bronk, Y Zhang, W Xu, TC Südhof
The EMBO journal 31 (4), 829-841, 2012
1702012
An autism‐associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor‐mediated synaptic transmission in hippocampus
MR Etherton, K Tabuchi, M Sharma, J Ko, TC Südhof
The EMBO journal 30 (14), 2908-2919, 2011
1602011
Determinants of the nuclear localization of the heterodimeric DNA fragmentation factor (ICAD/CAD)
D Lechardeur, L Drzymala, M Sharma, D Zylka, R Kinach, J Pacia, ...
The Journal of cell biology 150 (2), 321-334, 2000
1212000
Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ
A Pertsinidis, K Mukherjee, M Sharma, ZP Pang, SR Park, Y Zhang, ...
Proceedings of the National Academy of Sciences 110 (30), E2812-E2820, 2013
1142013
The role of the C terminus and Na+/H+ exchanger regulatory factor in the functional expression of cystic fibrosis transmembrane conductance regulator in nonpolarized cells and …
M Benharouga, M Sharma, J So, M Haardt, L Drzymala, M Popov, ...
Journal of Biological Chemistry 278 (24), 22079-22089, 2003
902003
Proteasome inhibition alleviates SNARE-dependent neurodegeneration
M Sharma, J Burré, TC Südhof
Science translational medicine 4 (147), 147ra113-147ra113, 2012
892012
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