Suivre
Tim Tree
Tim Tree
Professor of Immune Regulation and Immunotherapy, King's College London
Adresse e-mail validée de kcl.ac.uk
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Année
Guidelines for the use of flow cytometry and cell sorting in immunological studies
A Cossarizza, HD Chang, A Radbruch, A Acs, D Adam, S Adam‐Klages, ...
European journal of immunology 49 (10), 1457-1973, 2019
17192019
Defective suppressor function in CD4+ CD25+ T-cells from patients with type 1 diabetes
S Lindley, CM Dayan, A Bishop, BO Roep, M Peakman, TIM Tree
Diabetes 54 (1), 92-99, 2005
11392005
Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study
L Monin, AG Laing, M Muñoz-Ruiz, DR McKenzie, IDM Del Barrio, ...
The Lancet Oncology 22 (6), 765-778, 2021
5912021
Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health
S Arif, TI Tree, TP Astill, JM Tremble, AJ Bishop, CM Dayan, BO Roep, ...
The Journal of clinical investigation 113 (3), 451-463, 2004
5822004
CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
A Skowera, RJ Ellis, R Varela-Calviño, S Arif, GC Huang, C Van-Krinks, ...
The Journal of clinical investigation 118 (10), 3390-3402, 2008
4552008
Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death
S Arif, F Moore, K Marks, T Bouckenooghe, CM Dayan, R Planas, ...
Diabetes 60 (8), 2112-2119, 2011
2602011
Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+ CD25+ regulatory T cell function
G Garg, JR Tyler, JHM Yang, AJ Cutler, K Downes, M Pekalski, GL Bell, ...
The Journal of Immunology 188 (9), 4644-4653, 2012
2452012
Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes
JM Lawson, J Tremble, C Dayan, H Beyan, RDG Leslie, M Peakman, ...
Clinical & Experimental Immunology 154 (3), 353-359, 2008
2202008
Regulatory T cell dysfunction in type 1 diabetes: what’s broken and how can we fix it?
CM Hull, M Peakman, TIM Tree
Diabetologia 60 (10), 1839-1850, 2017
1932017
Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes
M Alhadj Ali, YF Liu, S Arif, D Tatovic, H Shariff, VB Gibson, N Yusuf, ...
Science translational medicine 9 (402), eaaf7779, 2017
1882017
The effect of methotrexate and targeted immunosuppression on humoral and cellular immune responses to the COVID-19 vaccine BNT162b2: a cohort study
SK Mahil, K Bechman, A Raharja, C Domingo-Vila, D Baudry, MA Brown, ...
The Lancet Rheumatology 3 (9), e627-e637, 2021
1652021
Systemic inflammatory response and neuromuscular involvement in amyotrophic lateral sclerosis
CH Lu, K Allen, F Oei, E Leoni, J Kuhle, T Tree, P Fratta, N Sharma, ...
Neurology: Neuroimmunology & Neuroinflammation 3 (4), e244, 2016
1592016
Immune modulation in humans: implications for type 1 diabetes mellitus
BO Roep, TIM Tree
Nature Reviews Endocrinology 10 (4), 229-242, 2014
1552014
CD 161 expression characterizes a subpopulation of human regulatory T cells that produces IL‐17 in a STAT 3‐dependent manner
B Afzali, PJ Mitchell, FC Edozie, GAM Povoleri, SE Dowson, L Demandt, ...
European journal of immunology 43 (8), 2043-2054, 2013
1532013
Phenotypic complexity of the human regulatory T cell compartment revealed by mass cytometry
GM Mason, K Lowe, R Melchiotti, R Ellis, E de Rinaldis, M Peakman, ...
The Journal of Immunology 195 (5), 2030-2037, 2015
1502015
Regulatory T cell responses in participants with type 1 diabetes after a single dose of interleukin-2: a non-randomised, open label, adaptive dose-finding trial
JA Todd, M Evangelou, AJ Cutler, ML Pekalski, NM Walker, HE Stevens, ...
PLoS medicine 13 (10), e1002139, 2016
1442016
Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture
JS Allen, K Pang, A Skowera, R Ellis, C Rackham, B Lozanoska-Ochser, ...
Diabetes 58 (1), 138-145, 2009
1382009
Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression
TIM Tree, J Lawson, H Edwards, A Skowera, S Arif, BO Roep, M Peakman
Diabetes 59 (6), 1451-1460, 2010
1182010
Generation of human islet-specific regulatory T cells by TCR gene transfer
CM Hull, LE Nickolay, M Estorninho, MW Richardson, JL Riley, ...
Journal of autoimmunity 79, 63-73, 2017
1162017
C-peptide decline in type 1 diabetes has two phases: an initial exponential fall and a subsequent stable phase
BM Shields, TJ McDonald, R Oram, A Hill, M Hudson, P Leete, ...
Diabetes care 41 (7), 1486-1492, 2018
1032018
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