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Dieter Drexler
Dieter Drexler
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Normalization strategies for metabonomic analysis of urine samples
BM Warrack, S Hnatyshyn, KH Ott, MD Reily, M Sanders, H Zhang, ...
Journal of Chromatography B 877 (5-6), 547-552, 2009
3542009
Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in …
DM Drexler, TJ Garrett, JL Cantone, RW Diters, JG Mitroka, ...
Journal of pharmacological and toxicological methods 55 (3), 279-288, 2007
1422007
An empirical process for the design of high-throughput screening deck filters
BC Pearce, MJ Sofia, AC Good, DM Drexler, DA Stock
Journal of chemical information and modeling 46 (3), 1060-1068, 2006
1102006
An automated liquid chromatography-mass spectrometry process to determine metabolic stability half-life and intrinsic clearance of drug candidates by substrate depletion
CA McNaney, DM Drexler, SY Hnatyshyn, TA Zvyaga, JO Knipe, ...
Assay and drug development technologies 6 (1), 121-129, 2008
1032008
Nocathiacins, new thiazolyl peptide antibiotics from Nocardia sp. II. Isolation, characterization, and structure determination
JE Leet, W Li, HA Ax, JA Matson, S Huang, R Huang, JL Cantone, ...
The Journal of Antibiotics 56 (3), 232-242, 2003
1022003
Nocathiacins, new thiazolyl peptide antibiotics from Nocardia sp. II. Isolation, characterization, and structure determination
JE Leet, W Li, HA Ax, JA Matson, S Huang, R Huang, JL Cantone, ...
The Journal of Antibiotics 56 (3), 232-242, 2003
1022003
Advances in mass spectrometry applied to pharmaceutical metabolomics
DM Drexler, MD Reily, PA Shipkova
Analytical and bioanalytical chemistry 399, 2645-2653, 2011
792011
Comparative evaluation of plasma bile acids, dehydroepiandrosterone sulfate, hexadecanedioate, and tetradecanedioate with coproporphyrins I and III as markers of OATP …
H Shen, W Chen, DM Drexler, S Mandlekar, VK Holenarsipur, EE Shields, ...
Drug Metabolism and Disposition 45 (8), 908-919, 2017
782017
The amyloid-β rise and γ-secretase inhibitor potency depend on the level of substrate expression
CR Burton, JE Meredith, DM Barten, ME Goldstein, CM Krause, CJ Kieras, ...
Journal of Biological Chemistry 283 (34), 22992-23003, 2008
772008
Extraction, identification, and functional characterization of a bioactive substance from automated compound-handling plastic tips
J Watson, EB Greenough, JE Leet, MJ Ford, DM Drexler, JV Belcastro, ...
SLAS Discovery 14 (5), 566-572, 2009
582009
P-glycoprotein efflux and other factors limit brain amyloid β reduction by β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice
JE Meredith, LA Thompson, JH Toyn, L Marcin, DM Barten, ...
Journal of Pharmacology and Experimental Therapeutics 326 (2), 502-513, 2008
542008
A high‐throughput bioanalytical platform using automated infusion for tandem mass spectrometric method optimization and its application in a metabolic stability screen
K Kieltyka, J Zhang, S Li, M Vath, C Baglieri, C Ferraro, TA Zvyaga, ...
Rapid Communications in Mass Spectrometry: An International Journal Devoted …, 2009
462009
The γ-secretase modulator, BMS-932481, modulates Aβ peptides in the plasma and cerebrospinal fluid of healthy volunteers
HD Soares, M Gasior, JH Toyn, JS Wang, Q Hong, F Berisha, MT Furlong, ...
Journal of Pharmacology and Experimental Therapeutics 358 (1), 138-150, 2016
452016
Application of ion trap technology to liquid chromatography/mass spectrometry quantitation of large peptides
P Shipkova, DM Drexler, R Langish, J Smalley, ME Salyan, M Sanders
Rapid Communications in Mass Spectrometry: An International Journal Devoted …, 2008
432008
Evidence for the validity of pyridoxic acid (PDA) as a plasma-based endogenous probe for OAT1 and OAT3 function in healthy subjects
H Shen, VK Holenarsipur, TT Mariappan, DM Drexler, JL Cantone, ...
Journal of Pharmacology and Experimental Therapeutics 368 (1), 136-145, 2019
422019
Utility of quantitative whole-body autoradiography (QWBA) and imaging mass spectrometry (IMS) by matrix-assisted laser desorption/ionization (MALDI) in the assessment of ocular …
DM Drexler, SH Tannehill-Gregg, L Wang, BJ Brock
Journal of pharmacological and toxicological methods 63 (2), 205-208, 2011
422011
2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV)(Part 1–small molecules, peptides and small molecule biomarkers by LCMS)
E Yang, J Welink, S Cape, E Woolf, J Sydor, C James, D Goykhman, ...
Bioanalysis 8 (22), 2363-2378, 2016
402016
An automated high throughput liquid chromatography–mass spectrometry process to assess the metabolic stability of drug candidates
DM Drexler, JV Belcastro, KE Dickinson, KJ Edinger, SY Hnatyshyn, ...
Assay and Drug Development Technologies 5 (2), 247-264, 2007
342007
Qualitative and quantitative characterization of the amyloid β peptide (Aβ) population in biological matrices using an immunoprecipitation–LC/MS assay
MJ Ford, JL Cantone, C Polson, JH Toyn, JE Meredith, DM Drexler
Journal of neuroscience methods 168 (2), 465-474, 2008
292008
Coupling laser diode thermal desorption with acoustic sample deposition to improve throughput of mass spectrometry–based screening
Z Haarhoff, A Wagner, P Picard, DM Drexler, T Zvyaga, W Shou
Journal of Biomolecular Screening 21 (2), 165-175, 2016
262016
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