Stefan Knapp
Stefan Knapp
Adresse e-mail validée de pharmchem.uni-frankfurt.de
TitreCitée parAnnée
Selective inhibition of BET bromodomains
P Filippakopoulos, J Qi, S Picaud, Y Shen, WB Smith, O Fedorov, ...
Nature 468 (7327), 1067, 2010
24512010
Histone recognition and large-scale structural analysis of the human bromodomain family
P Filippakopoulos, S Picaud, M Mangos, T Keates, JP Lambert, ...
Cell 149 (1), 214-231, 2012
9052012
Targeting bromodomains: epigenetic readers of lysine acetylation
P Filippakopoulos, S Knapp
Nature reviews Drug discovery 13 (5), 337-356, 2014
7632014
Protein production and purification
S Gräslund, P Nordlund, J Weigelt, BM Hallberg, J Bray, O Gileadi, ...
Nature methods 5 (2), 135, 2008
6942008
Critical residues for structure and catalysis in short-chain dehydrogenases/reductases
C Filling, KD Berndt, J Benach, S Knapp, T Prozorovski, E Nordling, ...
Journal of Biological Chemistry 277 (28), 25677-25684, 2002
5152002
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs
KL Kavanagh, K Guo, JE Dunford, X Wu, S Knapp, FH Ebetino, ...
Proceedings of the National Academy of Sciences 103 (20), 7829-7834, 2006
4992006
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536, 2015
4052015
Linear motif atlas for phosphorylation-dependent signaling
ML Miller, LJ Jensen, F Diella, C Jørgensen, M Tinti, L Li, M Hsiung, ...
Sci. Signal. 1 (35), ra2-ra2, 2008
3922008
Large-scale structural analysis of the classical human protein tyrosine phosphatome
AJ Barr, E Ugochukwu, WH Lee, ONF King, P Filippakopoulos, I Alfano, ...
Cell 136 (2), 352-363, 2009
3852009
Bromodomains as therapeutic targets
S Muller, P Filippakopoulos, S Knapp
Expert reviews in molecular medicine 13, 2011
3582011
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases
O Fedorov, B Marsden, V Pogacic, P Rellos, S Müller, AN Bullock, ...
Proceedings of the National Academy of Sciences 104 (51), 20523-20528, 2007
3462007
Small-molecule inhibition of BRDT for male contraception
MM Matzuk, MR McKeown, P Filippakopoulos, Q Li, L Ma, JE Agno, ...
Cell 150 (4), 673-684, 2012
3272012
Crystal structure of the tetrameric Mad1–Mad2 core complex: implications of a ‘safety belt’binding mechanism for the spindle checkpoint
L Sironi, M Mapelli, S Knapp, A De Antoni, KT Jeang, A Musacchio
The EMBO journal 21 (10), 2496-2506, 2002
3052002
The bromodomain interaction module
P Filippakopoulos, S Knapp
FEBS letters 586 (17), 2692-2704, 2012
2952012
PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers
L Brault, C Gasser, F Bracher, K Huber, S Knapp, J Schwaller
haematologica 95 (6), 1004-1015, 2010
2932010
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy
KVM Huber, E Salah, B Radic, M Gridling, JM Elkins, A Stukalov, ...
Nature 508 (7495), 222, 2014
2742014
Structural characterization of the GSK-3β active site using selective and non-selective ATP-mimetic inhibitors
JA Bertrand, S Thieffine, A Vulpetti, C Cristiani, B Valsasina, S Knapp, ...
Journal of molecular biology 333 (2), 393-407, 2003
2692003
The structure of P‐TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
S Baumli, G Lolli, ED Lowe, S Troiani, L Rusconi, AN Bullock, ...
The EMBO journal 27 (13), 1907-1918, 2008
2482008
RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain
S Picaud, C Wells, I Felletar, D Brotherton, S Martin, P Savitsky, ...
Proceedings of the National Academy of Sciences 110 (49), 19754-19759, 2013
2432013
The (un) targeted cancer kinome
O Fedorov, S Müller, S Knapp
Nature chemical biology 6 (3), 166, 2010
2422010
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