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Edgar E Boczek
Edgar E Boczek
Dewpoint Therapeutics
Adresse e-mail validée de dewpointx.com
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An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function
D Mateju, TM Franzmann, A Patel, A Kopach, EE Boczek, S Maharana, ...
The EMBO journal 36 (12), 1669-1687, 2017
2862017
Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90
EE Boczek, LG Reefschläger, M Dehling, TJ Struller, E Häusler, A Seidl, ...
Proceedings of the National Academy of Sciences 112 (25), E3189-E3198, 2015
782015
Her2-specific multivalent adapters confer designed tropism to adenovirus for gene targeting
B Dreier, G Mikheeva, N Belousova, P Parizek, E Boczek, I Jelesarov, ...
Journal of molecular biology 405 (2), 410-426, 2011
532011
Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease
RJ Wheeler, HO Lee, I Poser, A Pal, T Doeleman, S Kishigami, S Kour, ...
BioRxiv, 721001, 2019
522019
Features of the chaperone cellular network revealed through systematic interaction mapping
K Rizzolo, J Huen, A Kumar, S Phanse, J Vlasblom, Y Kakihara, ...
Cell reports 20 (11), 2735-2748, 2017
452017
Hsp90 dependence of a kinase is determined by its conformational landscape
Q Luo, EE Boczek, Q Wang, J Buchner, VRI Kaila
Scientific reports 7 (1), 1-11, 2017
232017
Autophosphorylation activates c-Src kinase through global structural rearrangements
EE Boczek, Q Luo, M Dehling, M Röpke, SL Mader, A Seidl, VRI Kaila, ...
Journal of Biological Chemistry 294 (35), 13186-13197, 2019
92019
HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain
EE Boczek, J Fürsch, ML Niedermeier, L Jawerth, M Jahnel, M Ruer-Gruß, ...
Elife 10, e69377, 2021
82021
Phase changes in neurotransmission
EE Boczek, S Alberti
Science 361 (6402), 548-549, 2018
82018
One domain fits all: Using disordered regions to sequester misfolded proteins
EE Boczek, S Alberti
The Journal of cell biology 217 (4), 1173, 2018
62018
Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease. bioRxiv: 721001
RJ Wheeler, HO Lee, I Poser, A Pal, T Doeleman, S Kishigami, S Kour, ...
N-terminal domain deletion ORF165-338 also significantly disrupts LLPS. NMR …, 2019
32019
The first Autumn School on Proteostasis: from molecular mechanisms to organismal consequences
E Boczek, G Gaglia, M Olshina, S Sarraf
Cell Stress and Chaperones 24 (3), 481-492, 2019
12019
Three complementary mechanisms of quality control ensure RNP granule functionality and dynamics.
D Mateju, E Boczek, J Wang, A Kopach, S Maharana, A Patel, HO Lee, ...
MOLECULAR BIOLOGY OF THE CELL 27, 2016
2016
The maturation of Src kinase by the molecular chaperone Hsp90 and its kinase specific cochaperone Cdc37
E Boczek
Technische Universität München, 2015
2015
Modification of Adenovirus Tropism with Designed Multi-Valent Targeting Adapters
B Dreier, G Mikheeva, N Belousova, P Parizek, E Boczek, I Jelesarov, ...
HUMAN GENE THERAPY 21 (10), 1366-1366, 2010
2010
Design of Bi-Specific DARPin-Derived Adapters for Targeting of Adenovirus Vectors
G Mikheeva, B Dreier, C Hess, E Boczek, N Belousova, A Plueckthun, ...
MOLECULAR THERAPY 17, S325-S325, 2009
2009
Supplementary Information-Hsp90 dependence of a kinase is determined by its conformational landscape
Q Luo, EE Boczek, Q Wang, J Buchner, VRI Kaila
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