Carsten Merkwirth, PhD
Carsten Merkwirth, PhD
Takeda Pharmaceuticals, Inc., San Diego, California, USA
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SLP‐2 is required for stress‐induced mitochondrial hyperfusion
D Tondera, S Grandemange, A Jourdain, M Karbowski, Y Mattenberger, ...
The EMBO journal 28 (11), 1589-1600, 2009
Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism
SD Jordan, M Krüger, DM Willmes, N Redemann, FT Wunderlich, ...
Nature cell biology 13 (4), 434-446, 2011
Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria
C Merkwirth, S Dargazanli, T Tatsuta, S Geimer, B Löwer, FT Wunderlich, ...
Genes & development 22 (4), 476-488, 2008
Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice
T Wai, J García-Prieto, MJ Baker, C Merkwirth, P Benit, P Rustin, ...
Science 350 (6265), aad0116, 2015
Prohibitin function within mitochondria: essential roles for cell proliferation and cristae morphogenesis
C Merkwirth, T Langer
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1793 (1), 27-32, 2009
RPN-6 determines C. elegans longevity under proteotoxic stress conditions
D Vilchez, I Morantte, Z Liu, PM Douglas, C Merkwirth, APC Rodrigues, ...
Nature 489 (7415), 263-268, 2012
Increased proteasome activity in human embryonic stem cells is regulated by PSMD11
D Vilchez, L Boyer, I Morantte, M Lutz, C Merkwirth, D Joyce, B Spencer, ...
Nature 489 (7415), 304-308, 2012
Prohibitins and the functional compartmentalization of mitochondrial membranes
C Osman, C Merkwirth, T Langer
Journal of cell science 122 (21), 3823-3830, 2009
Two conserved histone demethylases regulate mitochondrial stress-induced longevity
C Merkwirth, V Jovaisaite, J Durieux, O Matilainen, SD Jordan, PM Quiros, ...
Cell 165 (5), 1209-1223, 2016
TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling
CE Riera, MO Huising, P Follett, M Leblanc, J Halloran, R Van Andel, ...
Cell 157 (5), 1023-1036, 2014
Signaling networks determining life span
CE Riera, C Merkwirth, CD De Magalhaes Filho, A Dillin
Annual review of biochemistry 85, 35-64, 2016
Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration
C Merkwirth, P Martinelli, A Korwitz, M Morbin, HS Brönneke, SD Jordan, ...
PLoS genetics 8 (11), e1003021, 2012
Mitofusin 2 builds a bridge between ER and mitochondria
C Merkwirth, T Langer
Cell 135 (7), 1165-1167, 2008
Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria
A Korwitz, C Merkwirth, R Richter-Dennerlein, SE Tröder, HG Sprenger, ...
Journal of Cell Biology 212 (2), 157-166, 2016
Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD
N Hövelmeyer, FT Wunderlich, R Massoumi, CG Jakobsen, J Song, ...
The Journal of experimental medicine 204 (11), 2615-2627, 2007
Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development
S Supale, F Thorel, C Merkwirth, A Gjinovci, PL Herrera, L Scorrano, ...
Diabetes 62 (10), 3488-3499, 2013
Inhibition of insulin/IGF‐1 receptor signaling protects from mitochondria‐mediated kidney failure
C Ising, S Koehler, S Brähler, C Merkwirth, M Höhne, OR Baris, ...
EMBO Molecular Medicine 7 (3), 275-287, 2015
The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells
OR Baris, A Klose, JE Kloepper, D Weiland, JFG Neuhaus, M Schauen, ...
Stem Cells 29 (9), 1459-1468, 2011
FOXO 4 is necessary for neural differentiation of human embryonic stem cells
D Vilchez, L Boyer, M Lutz, C Merkwirth, I Morantte, C Tse, B Spencer, ...
Aging cell 12 (3), 518-522, 2013
Mitochondrial UPR: a double-edged sword
Y Tian, C Merkwirth, A Dillin
Trends in cell biology 26 (8), 563-565, 2016
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