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Umesh Desai
Umesh Desai
Professor of Medicinal Chemistry, Virginia Commonwealth University
Adresse e-mail validée de vcu.edu
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Mechanism of heparin activation of antithrombin: Role of individual residues of the pentasaccharide activating sequence in the recognition of native and activated states of …
UR Desai, M Petitou, I Björk, ST Olson
Journal of Biological Chemistry 273 (13), 7478-7487, 1998
2281998
Chemical sulfation of small molecules—Advances and challenges
RA Al-Horani, UR Desai
Tetrahedron 66 (16), 2907-2918, 2010
2162010
New antithrombin‐based anticoagulants
UR Desai
Medicinal Research Reviews 24 (2), 151-181, 2004
2032004
Specificity studies on the heparin lyases from Flavobacterium heparinum
UR Desai, HM Wang, RJ Linhardt
Biochemistry 32 (32), 8140-8145, 1993
2031993
Substrate specificity of the heparin lyases from Flavobacterium heparinum
UR Desai, HM Wang, RJ Linhardt
Archives of Biochemistry and Biophysics 306 (2), 461-468, 1993
1791993
Cytotoxic cell granule-mediated apoptosis: characterization of the macromolecular complex of granzyme B with serglycin
SM Raja, B Wang, M Dantuluri, UR Desai, B Demeler, K Spiegel, ...
Journal of Biological Chemistry 277 (51), 49523-49530, 2002
1502002
Oligosaccharide composition of heparin and low-molecular-weight heparins by capillary electrophoresis
UR Desai, HM Wang, SA Ampofo, RJ Linhardt
Analytical biochemistry 213 (1), 120-127, 1993
1251993
Antithrombotic and anticoagulant activities of a low molecular weight fucoidan by the subcutaneous route
J Millet, SC Jouault, S Mauray, J Theveniaux, C Sternberg, BC Vidal, ...
Thrombosis and haemostasis 81 (03), 391-395, 1999
1221999
1, 2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)
X He, AME Reeve, UR Desai, GE Kellogg, KA Reynolds
Antimicrobial agents and chemotherapy 48 (8), 3093-3102, 2004
1162004
Assessing the structural integrity of a lyophilized protein in organic solvents
UR Desai, AM Klibanov
Journal of the American Chemical Society 117 (14), 3940-3945, 1995
1151995
New developments in anticoagulants: past, present and future
JI Weitz, J Harenberg
Thrombosis and haemostasis 117 (07), 1283-1288, 2017
1092017
Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions
PRB Joseph, PD Mosier, UR Desai, K Rajarathnam
Biochemical Journal 472 (1), 121-133, 2015
1042015
A novel allosteric pathway of thrombin inhibition: Exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acids
BL Henry, BH Monien, PE Bock, UR Desai
Journal of biological chemistry 282 (44), 31891-31899, 2007
982007
Discovering small-molecule therapeutics against SARS-CoV-2
V Tiwari, JC Beer, NV Sankaranarayanan, M Swanson-Mungerson, ...
Drug Discovery Today 25 (8), 1535-1544, 2020
952020
Mechanism of heparin activation of antithrombin: evidence for an induced-fit model of allosteric activation involving two interaction subsites
UR Desai, M Petitou, I Björk, ST Olson
Biochemistry 37 (37), 13033-13041, 1998
941998
Sulfated pentagalloylglucoside is a potent, allosteric, and selective inhibitor of factor XIa
RA Al-Horani, P Ponnusamy, AY Mehta, D Gailani, UR Desai
Journal of medicinal chemistry 56 (3), 867-878, 2013
912013
Novel chemo-enzymatic oligomers of cinnamic acids as direct and indirect inhibitors of coagulation proteinases
BH Monien, BL Henry, A Raghuraman, M Hindle, UR Desai
Bioorganic & medicinal chemistry 14 (23), 7988-7998, 2006
872006
Recent advances on plasmin inhibitors for the treatment of fibrinolysis‐related disorders
RA Al‐Horani, UR Desai
Medicinal research reviews 34 (6), 1168-1216, 2014
862014
Interaction of heparin with synthetic antithrombin III peptide analogues
J Bae, UR Desai, A Pervin, EEO Caldwell, JM Weiler, RJ Linhardt
Biochemical Journal 301 (1), 121-129, 1994
841994
Finding a needle in a haystack: development of a combinatorial virtual screening approach for identifying high specificity heparin/heparan sulfate sequence (s)
A Raghuraman, PD Mosier, UR Desai
Journal of medicinal chemistry 49 (12), 3553-3562, 2006
832006
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