David Fruman
David Fruman
Professor of Molecular Biology & Biochemistry, UC Irvine
Adresse e-mail validée de uci.edu - Page d'accueil
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Phosphoinositide 3-kinases
DA Fruman
Handbook of Cell Signaling (Second Edition), 1049-1060, 2009
Phosphoinositide kinases
DA Fruman, RE Meyers, LC Cantley
Annual review of biochemistry 67 (1), 481-507, 1998
Phosphoinositide kinases
DA Fruman, RE Meyers, LC Cantley
Annual review of biochemistry 67 (1), 481-507, 1998
PI3K and cancer: lessons, challenges and opportunities
DA Fruman, C Rommel
Nature reviews Drug discovery 13 (2), 140-156, 2014
Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.
DA Fruman, CB Klee, BE Bierer, SJ Burakoff
Proceedings of the National Academy of Sciences 89 (9), 3686-3690, 1992
The PI3K pathway in human disease
DA Fruman, H Chiu, BD Hopkins, S Bagrodia, LC Cantley, RT Abraham
Cell 170 (4), 605-635, 2017
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α
DA Fruman, SB Snapper, CM Yballe, L Davidson, YY Jonathan, FW Alt, ...
Science 283 (5400), 393-397, 1999
Phosphatidylinositol‐3, 4, 5‐trisphosphate (PtdIns‐3, 4, 5‐P3)/Tec kinase‐dependent calcium signaling pathway: a target for SHIP‐mediated inhibitory signals
AM Scharenberg, O El‐Hillal, DA Fruman, LO Beitz, Z Li, S Lin, I Gout, ...
The EMBO Journal 17 (7), 1961-1972, 1998
Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
HW Chang, M Aoki, D Fruman, KR Auger, A Bellacosa, PN Tsichlis, ...
Science 276 (5320), 1848-1850, 1997
Phosphoinositide 3-Kinase: Diverse Roles in Immune Cell Activation
JA Deane, DA Fruman
Annu. Rev. Immunol. 22, 563-598, 2004
Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor
MR Janes, JJ Limon, L So, J Chen, RJ Lim, MA Chavez, C Vu, MB Lilly, ...
Nature medicine 16 (2), 205-213, 2010
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α
DA Fruman, F Mauvais-Jarvis, DA Pollard, CM Yballe, D Brazil, ...
Nature genetics 26 (3), 379-382, 2000
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival
K Ueki, DA Fruman, SM Brachmann, YH Tseng, LC Cantley, CR Kahn
Molecular and cellular biology 22 (3), 965-977, 2002
Immunophilins in protein folding and immunosuppression1
DA Fruman, SJ Burakoff, BE Bierer
The FASEB journal 8 (6), 391-400, 1994
Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
F Mauvais-Jarvis, K Ueki, DA Fruman, MF Hirshman, K Sakamoto, ...
The Journal of clinical investigation 109 (1), 141-149, 2002
Xid-like phenotypes: AB cell signalosome takes shape
DA Fruman, AB Satterthwaite, ON Witte
Immunity 13 (1), 1-3, 2000
Phosphoinositide 3-kinase in immunological systems
DA Fruman, LC Cantley
Seminars in immunology 14 (1), 7-18, 2002
Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology
BE Bierer, G Holländer, D Fruman, SJ Burakoff
Current opinion in immunology 5 (5), 763-773, 1993
Fine tuning the immune response with PI3K
DA Fruman, G Bismuth
Immunological reviews 228 (1), 253-272, 2009
Regulation of quiescence in lymphocytes
I Yusuf, DA Fruman
Trends in immunology 24 (7), 380-386, 2003
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