Paul J McLaren
Paul J McLaren
Research Scientist, JC Wilt Infectious Diseases Research Centre, NHRL, PHAC
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Defining the role of common variation in the genomic and biological architecture of adult human height
AR Wood, T Esko, J Yang, S Vedantam, TH Pers, S Gustafsson, AY Chu, ...
Nature genetics 46 (11), 1173-1186, 2014
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
International HIV Controllers Study
Science 330 (6010), 1551-1557, 2010
Exome sequencing and the genetic basis of complex traits
A Kiezun, K Garimella, R Do, NO Stitziel, BM Neale, PJ McLaren, N Gupta, ...
Nature genetics 44 (6), 623-630, 2012
Influence of HLA-C expression level on HIV control
R Apps, Y Qi, JM Carlson, H Chen, X Gao, R Thomas, Y Yuki, ...
Science 340 (6128), 87-91, 2013
Extremely low-coverage sequencing and imputation increases power for genome-wide association studies
B Pasaniuc, N Rohland, PJ McLaren, K Garimella, N Zaitlen, H Li, ...
Nature genetics 44 (6), 631-635, 2012
Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque
M Rotger, J Dalmau, A Rauch, P McLaren, SE Bosinger, R Martinez, ...
The Journal of clinical investigation 121 (6), 2391-2400, 2011
Decreased Immune Activation in Resistance to HIV-1 Infection Is Associated with an Elevated Frequency of CD4+CD25+FOXP3+ Regulatory T Cells
CM Card, PJ McLaren, C Wachihi, J Kimani, FA Plummer, KR Fowke
The Journal of infectious diseases 199 (9), 1318-1322, 2009
GWAS identifies novel susceptibility loci on 6p21. 32 and 21q21. 3 for hepatocellular carcinoma in chronic hepatitis B virus carriers
S Li, J Qian, Y Yang, W Zhao, J Dai, JX Bei, JN Foo, PJ McLaren, Z Li, ...
PLoS genetics 8 (7), e1002791, 2012
Guanylate binding protein (GBP) 5 is an interferon-inducible inhibitor of HIV-1 infectivity
C Krapp, D Hotter, A Gawanbacht, PJ McLaren, SF Kluge, CM Stürzel, ...
Cell host & microbe 19 (4), 504-514, 2016
HIV-Exposed Seronegative Commercial Sex Workers Show a Quiescent Phenotype in the CD4+ T Cell Compartment and Reduced Expression of HIV-Dependent …
PJ McLaren, T Blake Ball, C Wachihi, W Jaoko, DJ Kelvin, A Danesh, ...
The Journal of infectious diseases 202 (Supplement_3), S339-S344, 2010
Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants
ER Holzinger, B Grady, MD Ritchie, HJ Ribaudo, EP Acosta, GD Morse, ...
Pharmacogenetics and genomics 22 (12), 858, 2012
The impact of host genetic variation on infection with HIV-1
PJ McLaren, M Carrington
Nature immunology 16 (6), 577-583, 2015
Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load
PJ McLaren, C Coulonges, I Bartha, TL Lenz, AJ Deutsch, A Bashirova, ...
Proceedings of the National Academy of Sciences 112 (47), 14658-14663, 2015
Polymorphisms in IRF-1 associated with resistance to HIV-1 infection in highly exposed uninfected Kenyan sex workers
TB Ball, H Ji, J Kimani, P McLaren, C Marlin, AVS Hill, FA Plummer
Aids 21 (9), 1091-1101, 2007
HIV-1 capture and transmission by dendritic cells: the role of viral glycolipids and the cellular receptor Siglec-1
N Izquierdo-Useros, M Lorizate, PJ McLaren, A Telenti, HG Kräusslich, ...
PLoS pathogens 10 (7), e1004146, 2014
Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls
PJ McLaren, C Coulonges, S Ripke, L Van Den Berg, S Buchbinder, ...
PLoS pathogens 9 (7), e1003515, 2013
Cohorts for the study of hiv-1—exposed but uninfected individuals: Benefits and limitations
RE Horton, PJ McLaren, K Fowke, J Kimani, TB Ball
The Journal of infectious diseases 202 (Supplement_3), S377-S381, 2010
The role of regulatory T cells in chronic and acute viral infections
Y Keynan, CM Card, PJ McLaren, MR Dawood, K Kasper, KR Fowke
Clinical infectious diseases 46 (7), 1046-1052, 2008
A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control
I Bartha, JM Carlson, CJ Brumme, PJ McLaren, ZL Brumme, M John, ...
elife 2, e01123, 2013
Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease
S Kulkarni, Y Qi, C O’hUigin, F Pereyra, V Ramsuran, P McLaren, J Fellay, ...
Proceedings of the National Academy of Sciences 110 (51), 20705-20710, 2013
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