Hugo Fraga
Hugo Fraga
Faculdade de Medicina da Universidade do Porto
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Firefly luminescence: a historical perspective and recent developments
H Fraga
Photochemical & Photobiological Sciences 7 (2), 146-158, 2008
Thermostable red and green light-producing firefly luciferase mutants for bioluminescent reporter applications
BR Branchini, DM Ablamsky, MH Murtiashaw, L Uzasci, H Fraga, ...
Analytical biochemistry 361 (2), 253-262, 2007
ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle
DM Smith, H Fraga, C Reis, G Kafri, AL Goldberg
Cell 144 (4), 526-538, 2011
Coenzyme A affects firefly luciferase luminescence because it acts as a substrate and not as an allosteric effector
H Fraga, D Fernandes, R Fontes, JCG Esteves da Silva
The FEBS journal 272 (20), 5206-5216, 2005
Firefly luciferase produces hydrogen peroxide as a coproduct in dehydroluciferyl adenylate formation
H Fraga, D Fernandes, J Novotny, R Fontes, JCG Esteves da Silva
ChemBioChem 7 (6), 929-935, 2006
Identification of luciferyl adenylate and luciferyl coenzyme a synthesized by firefly luciferase
H Fraga, JCG Esteves da Silva, R Fontes
ChemBioChem 5 (1), 110-115, 2004
Pyrophosphate and tripolyphosphate affect firefly luciferase luminescence because they act as substrates and not as allosteric effectors
R Fontes, D Fernandes, F Peralta, H Fraga, I Maio, JCG Esteves da Silva
The FEBS journal 275 (7), 1500-1509, 2008
Solid‐state NMR H–N–(C)–H and H–N–C–C 3D/4D correlation experiments for resonance assignment of large proteins
H Fraga, CA Arnaud, DF Gauto, M Audin, V Kurauskas, P Macek, ...
ChemPhysChem 18 (19), 2697-2703, 2017
Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors
J Felix, K Weinhäupl, C Chipot, F Dehez, A Hessel, DF Gauto, C Morlot, ...
Science advances 5 (9), eaaw3818, 2019
Enzymatic synthesis of mono and dinucleoside polyphosphates
H Fraga, R Fontes
Biochimica et Biophysica Acta (BBA)-General Subjects 1810 (12), 1195-1204, 2011
FH8 – a small EF‐hand protein from Fasciola hepatica
H Fraga, TQ Faria, F Pinto, A Almeida, RMM Brito, AM Damas
The FEBS journal 277 (24), 5072-5085, 2010
Association between foldability and aggregation propensity in small disulfide-rich proteins
H Fraga, R Grana-Montes, R Illa, G Covaleda, S Ventura
Antioxidants & redox signaling 21 (3), 368-383, 2014
The antibiotic cyclomarin blocks arginine-phosphate–induced millisecond dynamics in the N-terminal domain of ClpC1 from Mycobacterium tuberculosis
K Weinhäupl, M Brennich, U Kazmaier, J Lelièvre, L Ballell, A Goldberg, ...
Journal of Biological Chemistry 293 (22), 8379-8393, 2018
Characterization of rat heart alkaline phosphatase isoenzymes and modulation of activity
A Mota, P Silva, D Neves, C Lemos, C Calhau, D Torres, F Martel, ...
Brazilian Journal of Medical and Biological Research 41 (7), 600-609, 2008
Aromatic Ring Dynamics, Thermal Activation, and Transient Conformations of a 468 kDa Enzyme by Specific 1H–13C Labeling and Fast Magic-Angle Spinning NMR
DF Gauto, P Macek, A Barducci, H Fraga, A Hessel, T Terauchi, D Gajan, ...
Journal of the American Chemical Society 141 (28), 11183-11195, 2019
The mitochondrial intermembrane space oxireductase Mia40 funnels the oxidative folding pathway of the cytochrome c oxidase assembly protein Cox19
H Fraga, JJ Bech-Serra, F Canals, G Ortega, O Millet, S Ventura
Journal of Biological Chemistry 289 (14), 9852-9864, 2014
pH opposite effects on synthesis of dinucleoside polyphosphates and on oxidation reactions catalyzed by firefly luciferase
H Fraga, JCGE da Silva, R Fontes
FEBS letters 543 (1-3), 37-41, 2003
Chemical synthesis and firefly luciferase produced dehydroluciferyl-coenzyme A
H Fraga, JCGE da Silva, R Fontes
Tetrahedron letters 45 (10), 2117-2120, 2004
Disulfide driven folding for a conditionally disordered protein
H Fraga, J Pujols, M Gil-Garcia, A Roque, G Bernardo-Seisdedos, ...
Scientific reports 7 (1), 1-16, 2017
Zinc induced folding is essential for TIM15 activity as an mtHsp70 chaperone
H Fraga, E Papaleo, S Vega, A Velazquez-Campoy, S Ventura
Biochimica et Biophysica Acta (BBA)-General Subjects 1830 (1), 2139-2149, 2013
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