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Thomas Kleyman
Thomas Kleyman
Adresse e-mail validée de pitt.edu
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Amiloride and its analogs as tools in the study of ion transport.
TR Kleyman, EJ Cragoe Jr
The Journal of membrane biology 105 (1), 1-21, 1988
14201988
Epithelial sodium channels are activated by furin-dependent proteolysis
RP Hughey, JB Bruns, CL Kinlough, KL Harkleroad, Q Tong, ...
Journal of Biological Chemistry 279 (18), 18111-18114, 2004
4302004
ENaC at the cutting edge: regulation of epithelial sodium channels by proteases
TR Kleyman, MD Carattino, RP Hughey
Journal of Biological Chemistry 284 (31), 20447-20451, 2009
3512009
Epithelial Na+ channels are fully activated by furin-and prostasin-dependent release of an inhibitory peptide from the γ-subunit
JB Bruns, MD Carattino, S Sheng, AB Maarouf, OA Weisz, JM Pilewski, ...
Journal of Biological Chemistry 282 (9), 6153-6160, 2007
3502007
Maturation of the epithelial Na+ channel involves proteolytic processing of the α-and γ-subunits
RP Hughey, GM Mueller, JB Bruns, CL Kinlough, PA Poland, ...
Journal of Biological Chemistry 278 (39), 37073-37082, 2003
3062003
Flow-dependent K+ secretion in the cortical collecting duct is mediated by a maxi-K channel
CB Woda, A Bragin, TR Kleyman, LM Satlin
American Journal of Physiology-Renal Physiology 280 (5), F786-F793, 2001
3062001
Subunit stoichiometry of the epithelial sodium channel
F Kosari, S Sheng, J Li, DOD Mak, JK Foskett, TR Kleyman
Journal of Biological Chemistry 273 (22), 13469-13474, 1998
2731998
Epithelial Na+ channels are regulated by flow
LM Satlin, S Sheng, CB Woda, TR Kleyman
American Journal of Physiology-Renal Physiology 280 (6), F1010-F1018, 2001
2432001
Aldosterone alters the open probability of amiloride-blockable sodium channels in A6 epithelia
AE Kemendy, TR Kleyman, DC Eaton
American Journal of Physiology-Cell Physiology 263 (4), C825-C837, 1992
2331992
Plasmin activates epithelial Na+ channels by cleaving the γ subunit
CJ Passero, GM Mueller, H Rondon-Berrios, SP Tofovic, RP Hughey, ...
Journal of Biological Chemistry 283 (52), 36586-36591, 2008
2122008
Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition
S Sheng, MD Carattino, JB Bruns, RP Hughey, TR Kleyman
American Journal of Physiology-Renal Physiology 290 (6), F1488-F1496, 2006
2002006
Distinct pools of epithelial sodium channels are expressed at the plasma membrane
RP Hughey, JB Bruns, CL Kinlough, TR Kleyman
Journal of Biological Chemistry 279 (47), 48491-48494, 2004
1872004
Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels
SB Goldfarb, OB Kashlan, JN Watkins, L Suaud, W Yan, TR Kleyman, ...
Proceedings of the National Academy of Sciences 103 (15), 5817-5822, 2006
1862006
Epithelial Na+ channels are activated by laminar shear stress
MD Carattino, S Sheng, TR Kleyman
Journal of Biological Chemistry 279 (6), 4120-4126, 2004
1832004
The epithelial Na+ channel is inhibited by a peptide derived from proteolytic processing of its α subunit
MD Carattino, S Sheng, JB Bruns, JM Pilewski, RP Hughey, TR Kleyman
Journal of Biological Chemistry 281 (27), 18901-18907, 2006
1792006
ENaC structure and function in the wake of a resolved structure of a family member
OB Kashlan, TR Kleyman
American Journal of Physiology-Renal Physiology 301 (4), F684-F696, 2011
1752011
Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells
MD Carattino, RS Edinger, HJ Grieser, R Wise, D Neumann, U Schlattner, ...
Journal of Biological Chemistry 280 (18), 17608-17616, 2005
1572005
Trimethoprim-induced hyperkalemia in a patient with AIDS
MJ Choi, PC Fernandez, A Patnaik, B Coupaye-Gerard, D D'andrea, ...
New england journal of medicine 328 (10), 703-706, 1993
1571993
Role of epithelial sodium channels and their regulators in hypertension
R Soundararajan, D Pearce, RP Hughey, TR Kleyman
Journal of Biological Chemistry 285 (40), 30363-30369, 2010
1382010
Proteolytic processing of the epithelial sodium channel γ subunit has a dominant role in channel activation
MD Carattino, RP Hughey, TR Kleyman
Journal of biological chemistry 283 (37), 25290-25295, 2008
1362008
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