| Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy RA Friesner, JL Banks, RB Murphy, TA Halgren, JJ Klicic, DT Mainz, ... Journal of medicinal chemistry 47 (7), 1739-1749, 2004 | 9285 | 2004 |
| Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency CJ Gordon, EP Tchesnokov, E Woolner, JK Perry, JY Feng, DP Porter, ... Journal of Biological Chemistry 295 (20), 6785-6797, 2020 | 942 | 2020 |
| Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and … D Siegel, HC Hui, E Doerffler, MO Clarke, K Chun, L Zhang, S Neville, ... Journal of medicinal chemistry 60 (5), 1648-1661, 2017 | 755 | 2017 |
| Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice AJ Pruijssers, AS George, A Schäfer, SR Leist, LE Gralinksi, KH Dinnon, ... Cell reports 32 (3), 2020 | 481 | 2020 |
| Structural basis for RNA replication by the hepatitis C virus polymerase TC Appleby, JK Perry, E Murakami, O Barauskas, J Feng, A Cho, D Fox III, ... Science 347 (6223), 771-775, 2015 | 331 | 2015 |
| Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection JO Link, JG Taylor, L Xu, M Mitchell, H Guo, H Liu, D Kato, T Kirschberg, ... Journal of medicinal chemistry 57 (5), 2033-2046, 2014 | 314 | 2014 |
| Antiferromagnetic band structure of Becke-3–Lee-Yang-Parr calculations JK Perry, J Tahir-Kheli, WA Goddard III Physical Review B 63 (14), 144510, 2001 | 158 | 2001 |
| Discovery of the First C-Nucleoside HCV Polymerase Inhibitor (GS-6620) with Demonstrated Antiviral Response in HCV Infected Patients A Cho, L Zhang, J Xu, R Lee, T Butler, S Metobo, V Aktoudianakis, W Lew, ... Journal of medicinal chemistry 57 (5), 1812-1825, 2014 | 156 | 2014 |
| Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action EP Tchesnokov, CJ Gordon, E Woolner, D Kocinkova, JK Perry, JY Feng, ... Journal of Biological Chemistry 295 (47), 16156-16165, 2020 | 142 | 2020 |
| Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides JJ Arnold, SD Sharma, JY Feng, AS Ray, ED Smidansky, ML Kireeva, ... PLoS pathogens 8 (11), e1003030, 2012 | 141 | 2012 |
| RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information TA Kirschberg, M Balakrishnan, NH Squires, T Barnes, KM Brendza, ... Journal of medicinal chemistry 52 (19), 5781-5784, 2009 | 121 | 2009 |
| Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms LJ Stevens, AJ Pruijssers, HW Lee, CJ Gordon, EP Tchesnokov, J Gribble, ... Science translational medicine 14 (656), eabo0718, 2022 | 116 | 2022 |
| Molecular complexes of small alkanes with cobalt (1+) JK Perry, G Ohanessian, WA Goddard III The Journal of physical chemistry 97 (20), 5238-5245, 1993 | 108 | 1993 |
| Advanced initial-guess algorithm for self-consistent-field calculations on organometallic systems G Vacek, JK Perry, JM Langlois Chemical physics letters 310 (1-2), 189-194, 1999 | 104 | 1999 |
| Mechanism and energetics for dehydrogenation of methane by gaseous iridium ions JK Perry, G Ohanessian, WA Goddard III Organometallics 13 (5), 1870-1877, 1994 | 99 | 1994 |
| Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors EB Lansdon, Q Liu, SA Leavitt, M Balakrishnan, JK Perry, ... Antimicrobial agents and chemotherapy 55 (6), 2905-2915, 2011 | 93 | 2011 |
| Phosphonate inhibitors of HCV CG Boojamra, JM Chen, AX Huang, CU Kim, KY Lin, RL Mackman, ... US Patent 7,842,672, 2010 | 85 | 2010 |
| Identification and optimization of pteridinone Toll-like receptor 7 (TLR7) agonists for the oral treatment of viral hepatitis PA Roethle, RM McFadden, H Yang, P Hrvatin, H Hui, M Graupe, ... Journal of medicinal chemistry 56 (18), 7324-7333, 2013 | 84 | 2013 |
| Role of mitochondrial RNA polymerase in the toxicity of nucleotide inhibitors of hepatitis C virus JY Feng, Y Xu, O Barauskas, JK Perry, S Ahmadyar, G Stepan, H Yu, ... Antimicrobial agents and chemotherapy 60 (2), 806-817, 2016 | 81 | 2016 |
| Theoretical studies of a hydrogen abstraction tool for nanotechnology CB Musgrave, JK Perry, RC Merkle, WA Goddard Nanotechnology 2 (4), 187, 1991 | 74 | 1991 |
