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Jacob Brown
Jacob Brown
OMRF
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Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice
JL Brown, ME Rosa‐Caldwell, DE Lee, TA Blackwell, LA Brown, RA Perry, ...
Journal of cachexia, sarcopenia and muscle 8 (6), 926-938, 2017
2562017
Mitochondrial quality control, promoted by PGC‐1α, is dysregulated by Western diet‐induced obesity and partially restored by moderate physical activity in mice
NP Greene, DE Lee, JL Brown, ME Rosa, LA Brown, RA Perry, JN Henry, ...
Physiological reports 3 (7), e12470, 2015
1872015
Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
JL Brown, DE Lee, ME Rosa‐Caldwell, LA Brown, RA Perry, WS Haynie, ...
Journal of cachexia, sarcopenia and muscle 9 (5), 987-1002, 2018
942018
microRNA‐16 is downregulated during insulin resistance and controls skeletal muscle protein accretion
DE Lee, JL Brown, ME Rosa, LA Brown, RA Perry Jr, MP Wiggs, ...
Journal of cellular biochemistry 117 (8), 1775-1787, 2016
722016
Moderate physical activity promotes basal hepatic autophagy in diet-induced obese mice
ME Rosa-Caldwell, DE Lee, JL Brown, LA Brown, RA Perry Jr, ES Greene, ...
Applied Physiology, Nutrition, and Metabolism 42 (2), 148-156, 2017
642017
Diet‐induced obesity alters anabolic signalling in mice at the onset of skeletal muscle regeneration
LA Brown, DE Lee, JF Patton, RA Perry Jr, JL Brown, JI Baum, ...
Acta physiologica 215 (1), 46-57, 2015
642015
Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size
DE Lee, JL Brown, ME Rosa-Caldwell, TA Blackwell, RA Perry Jr, ...
Physiological genomics 49 (5), 253-260, 2017
632017
Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy
ME Rosa‐Caldwell, S Lim, WA Haynie, JL Brown, JW Deaver, ...
Journal of cachexia, sarcopenia and muscle 12 (3), 717-730, 2021
412021
Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice
TA Blackwell, I Cervenka, B Khatri, JL Brown, ME Rosa-Caldwell, DE Lee, ...
Physiological genomics 50 (12), 1071-1082, 2018
412018
Development and progression of cancer cachexia: Perspectives from bench to bedside
S Lim, JL Brown, TA Washington, NP Greene
Sports medicine and health science 2 (4), 177-185, 2020
402020
Cancer cachexia in a mouse model of oxidative stress
JL Brown, MM Lawrence, B Ahn, P Kneis, KM Piekarz, R Qaisar, R Ranjit, ...
Journal of cachexia, sarcopenia and muscle 11 (6), 1688-1704, 2020
392020
Hepatic alterations during the development and progression of cancer cachexia
ME Rosa-Caldwell, JL Brown, DE Lee, MP Wiggs, RA Perry Jr, ...
Applied Physiology, Nutrition, and Metabolism 45 (5), 500-512, 2020
372020
Neuron‐specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice
S Bhaskaran, N Pollock, P C Macpherson, B Ahn, KM Piekarz, ...
Aging Cell 19 (10), e13225, 2020
322020
PGC‐1α4 gene expression is suppressed by the IL‐6—MEK—ERK 1/2 MAPK signalling axis and altered by resistance exercise, obesity and muscle injury
JL Brown, ME Rosa‐Caldwell, DE Lee, LA Brown, RA Perry, KL Shimkus, ...
Acta Physiologica 220 (2), 275-288, 2017
292017
Translational machinery of mitochondrial mRNA is promoted by physical activity in Western diet‐induced obese mice
DE Lee, JL Brown, ME Rosa, LA Brown, RA Perry, TA Washington, ...
Acta Physiologica 218 (3), 167-177, 2016
252016
Differential effects of leucine supplementation in young and aged mice at the onset of skeletal muscle regeneration
RA Perry Jr, LA Brown, DE Lee, JL Brown, JI Baum, NP Greene, ...
Mechanisms of ageing and development 157, 7-16, 2016
242016
Targeting cPLA2 derived lipid hydroperoxides as a potential intervention for sarcopenia
G Pharaoh, JL Brown, K Sataranatarajan, P Kneis, J Bian, R Ranjit, ...
Scientific reports 10 (1), 13968, 2020
232020
Molecular changes in transcription and metabolic pathways underlying muscle atrophy in the CuZnSOD null mouse model of sarcopenia
K Sataranatarajan, G Pharaoh, JL Brown, R Ranjit, KM Piekarz, K Street, ...
Geroscience 42, 1101-1118, 2020
222020
Cancer‐induced cardiac atrophy adversely affects myocardial redox state and mitochondrial oxidative characteristics
DE Lee, JL Brown, ME Rosa‐Caldwell, RA Perry, LA Brown, WS Haynie, ...
JCSM rapid communications 4 (1), 3-15, 2021
182021
Skeletal muscle insulin resistance as a precursor to diabetes: beyond glucoregulation
NP Greene, JL Brown, ME Rosa-Caldwell, DE Lee, TA Blackwell, ...
Current diabetes reviews 14 (2), 113-128, 2018
182018
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