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Lawrence Middleton
Lawrence Middleton
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Prioritizing non-coding regions based on human genomic constraint and sequence context with deep learning
D Vitsios, RS Dhindsa, L Middleton, AB Gussow, S Petrovski
Nature communications 12 (1), 1504, 2021
502021
Unbiased Markov chain Monte Carlo for intractable target distributions
L Middleton, G Deligiannidis, A Doucet, PE Jacob
322020
Unbiased smoothing using particle independent Metropolis-Hastings
L Middleton, G Deligiannidis, A Doucet, PE Jacob
The 22nd International Conference on Artificial Intelligence and Statistics …, 2019
252019
Assessing the contribution of rare-to-common protein-coding variants to circulating metabolic biomarker levels via 412,394 UK Biobank exome sequences
A Nag, L Middleton, RS Dhindsa, D Vitsios, E Wigmore, EL Allman, ...
MedRxiv, 2021.12. 24.21268381, 2021
122021
DrugnomeAI is an ensemble machine-learning framework for predicting druggability of candidate drug targets
A Raies, E Tulodziecka, J Stainer, L Middleton, RS Dhindsa, P Hill, ...
Communications Biology 5 (1), 1291, 2022
102022
Effects of protein-coding variants on blood metabolite measurements and clinical biomarkers in the UK Biobank
A Nag, RS Dhindsa, L Middleton, X Jiang, D Vitsios, E Wigmore, ...
The American Journal of Human Genetics 110 (3), 487-498, 2023
62023
Gene-SCOUT: identifying genes with similar continuous trait fingerprints from phenome-wide association analyses
L Middleton, AR Harper, A Nag, Q Wang, A Reznichenko, D Vitsios, ...
Nucleic Acids Research 50 (8), 4289-4301, 2022
42022
Analysis of 983 civilian blast and ballistic casualties and the generation of a template of injury burden: An observational study
L Maitland, L Middleton, H Veen, DJ Harrison, J Baden, S Hettiaratchy
EClinicalMedicine 54, 2022
22022
Applying Machine Learning on UK Biobank biomarker data empowers case-control discovery yield
M Garg, M Karpinski, D Matelska, L Middleton, J Mitchell, A O'Neill, ...
medRxiv, 2023.10. 10.23296832, 2023
2023
Assessing the role of rare pathogenic variants in heart failure progression by exome sequencing in 8,089 patients
O Chazara, MP Dubé, Q Wang, L Middleton, D Vitsios, A Walentinsson, ...
medRxiv, 2023.07. 28.23293350, 2023
2023
Trading styles and long-run variance of asset prices
L Middleton, J Dodd, S Rijavec
arXiv preprint arXiv:2109.08242, 2021
2021
Scalable inference in state-space models
L Middleton
University of Oxford, 2019
2019
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