| Mitochondrial dysfunction, through impaired autophagy, leads to endoplasmic reticulum stress, deregulated lipid metabolism, and pancreatitis in animal models G Biczo, ET Vegh, N Shalbueva, OA Mareninova, J Elperin, E Lotshaw, ... Gastroenterology 154 (3), 689-703, 2018 | 293 | 2018 |
| Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload GC Preza, P Ruchala, R Pinon, E Ramos, B Qiao, MA Peralta, S Sharma, ... The Journal of clinical investigation 121 (12), 4880-4888, 2011 | 285 | 2011 |
| Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis E Ramos, P Ruchala, JB Goodnough, L Kautz, GC Preza, E Nemeth, ... Blood, The Journal of the American Society of Hematology 120 (18), 3829-3836, 2012 | 251 | 2012 |
| Hepcidin-induced hypoferremia is a critical host defense mechanism against the siderophilic bacterium Vibrio vulnificus J Arezes, G Jung, V Gabayan, E Valore, P Ruchala, PA Gulig, T Ganz, ... Cell host & microbe 17 (1), 47-57, 2015 | 226 | 2015 |
| Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I BJ Van Lenten, AC Wagner, CL Jung, P Ruchala, AJ Waring, RI Lehrer, ... Journal of lipid research 49 (11), 2302-2311, 2008 | 214 | 2008 |
| β-defensin inhibits influenza virus replication by cell-mediated mechanism (s) M Salvatore, A García-Sastre, P Ruchala, RI Lehrer, T Chang, ... Journal of Infectious Diseases 196 (6), 835-843, 2007 | 193 | 2007 |
| The pathophysiology and pharmacology of hepcidin P Ruchala, E Nemeth Trends in pharmacological sciences 35 (3), 155-161, 2014 | 183 | 2014 |
| Interactions of α-, β-, and θ-defensins with influenza A virus and surfactant protein D M Doss, MR White, T Tecle, D Gantz, EC Crouch, G Jung, P Ruchala, ... The Journal of Immunology 182 (12), 7878-7887, 2009 | 182 | 2009 |
| Roles of Arginine and Lysine Residues in the Translocation of a Cell-Penetrating Peptide from 13C, 31P, and 19F Solid-State NMR Y Su, T Doherty, AJ Waring, P Ruchala, M Hong Biochemistry 48 (21), 4587-4595, 2009 | 156 | 2009 |
| Uncovering the mechanism of aggregation of human transthyretin L Saelices, LM Johnson, WY Liang, MR Sawaya, D Cascio, P Ruchala, ... Journal of Biological Chemistry 290 (48), 28932-28943, 2015 | 155 | 2015 |
| Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non–transferrin-bound iron D Stefanova, A Raychev, J Arezes, P Ruchala, V Gabayan, M Skurnik, ... Blood, The Journal of the American Society of Hematology 130 (3), 245-257, 2017 | 132 | 2017 |
| Reawakening retrocyclins: ancestral human defensins active against HIV-1 N Venkataraman, AL Cole, P Ruchala, AJ Waring, RI Lehrer, O Stuchlik, ... PLoS biology 7 (4), e1000095, 2009 | 129 | 2009 |
| Multivalent binding of carbohydrates by the human α-defensin, HD5 RI Lehrer, G Jung, P Ruchala, S Andre, HJ Gabius, W Lu The Journal of Immunology 183 (1), 480-490, 2009 | 114 | 2009 |
| Membrane-bound dynamic structure of an arginine-rich cell-penetrating peptide, the protein transduction domain of HIV TAT, from solid-state NMR Y Su, AJ Waring, P Ruchala, M Hong Biochemistry 49 (29), 6009-6020, 2010 | 110 | 2010 |
| Lateral stress relaxation and collapse in lipid monolayers L Pocivavsek, SL Frey, K Krishan, K Gavrilov, P Ruchala, AJ Waring, ... Soft matter 4 (10), 2019-2029, 2008 | 81 | 2008 |
| Human α-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins RI Lehrer, G Jung, P Ruchala, W Wang, ED Micewicz, AJ Waring, ... Infection and immunity 77 (9), 4028-4040, 2009 | 75 | 2009 |
| A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids M Navab, P Ruchala, AJ Waring, RI Lehrer, S Hama, G Hough, ... Journal of lipid research 50 (8), 1538-1547, 2009 | 73 | 2009 |
| A peptide hairpin inhibitor of amyloid β-protein oligomerization and fibrillogenesis G Yamin, P Ruchala, DB Teplow Biochemistry 48 (48), 11329-11331, 2009 | 68 | 2009 |
| Hepcidin protects against lethal Escherichia coli sepsis in mice inoculated with isolates from septic patients D Stefanova, A Raychev, J Deville, R Humphries, S Campeau, P Ruchala, ... Infection and immunity 86 (7), 10.1128/iai. 00253-18, 2018 | 59 | 2018 |
| The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques AM Cole, DL Patton, LC Rohan, AL Cole, Y Cosgrove-Sweeney, ... PLoS One 5 (11), e15111, 2010 | 58 | 2010 |
