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Lyn-Marie Birkholtz
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Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
T Paquet, C Le Manach, DG Cabrera, Y Younis, PP Henrich, TS Abraham, ...
Science translational medicine 9 (387), eaad9735, 2017
2412017
Discovery of novel alkylated (bis) urea and (bis) thiourea polyamine analogues with potent antimalarial activities
BK Verlinden, J Niemand, J Snyman, SK Sharma, RJ Beattie, PM Woster, ...
Journal of medicinal chemistry 54 (19), 6624-6633, 2011
1202011
Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards …
J Reader, M Botha, A Theron, SB Lauterbach, C Rossouw, D Engelbrecht, ...
Malaria journal 14, 1-17, 2015
1192015
Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities
LM Birkholtz, M Williams, J Niemand, AI Louw, L Persson, O Heby
Biochemical Journal 438 (2), 229-244, 2011
1132011
Co-inhibition of Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory mechanisms by transcriptome …
AC van Brummelen, KL Olszewski, D Wilinski, M Llinas, AI Louw, ...
Journal of Biological Chemistry 284 (7), 4635-4646, 2009
1072009
Heterologous expression of plasmodial proteins for structural studies and functional annotation
LM Birkholtz, G Blatch, TL Coetzer, HC Hoppe, E Human, EJ Morris, ...
Malaria journal 7, 1-20, 2008
1072008
Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation
R Van Biljon, R Van Wyk, HJ Painter, L Orchard, J Reader, J Niemand, ...
BMC genomics 20, 1-16, 2019
782019
Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum parasites
N Coetzee, S Sidoli, R Van Biljon, H Painter, M Llinás, BA Garcia, ...
Scientific reports 7 (1), 607, 2017
762017
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
J Reader, ME van der Watt, D Taylor, C Le Manach, N Mittal, S Ottilie, ...
Nature communications 12 (1), 269, 2021
672021
UCT943, a next-generation Plasmodium falciparum PI4K inhibitor preclinical candidate for the treatment of malaria
C Brunschwig, N Lawrence, D Taylor, E Abay, M Njoroge, GS Basarab, ...
Antimicrobial agents and chemotherapy 62 (9), 10.1128/aac. 00012-18, 2018
622018
Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites
N Coetzee, H von Grüning, D Opperman, M van der Watt, J Reader, ...
Scientific reports 10 (1), 2355, 2020
582020
Discovering new transmission-blocking antimalarial compounds: challenges and opportunities
LM Birkholtz, TL Coetzer, D Mancama, D Leroy, P Alano
Trends in parasitology 32 (9), 669-681, 2016
582016
Synthesis and in vitro biological evaluation of dihydroartemisinyl-chalcone esters
FJ Smit, RA van Biljon, LM Birkholtz, DND David
European journal of medicinal chemistry 90, 33-44, 2015
582015
Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain …
LM Birkholtz, C Wrenger, F Joubert, GA Wells, RD Walter, AI Louw
Biochemical Journal 377 (2), 439-448, 2004
552004
Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in …
K Singh, J Okombo, C Brunschwig, F Ndubi, L Barnard, C Wilkinson, ...
Journal of medicinal chemistry 60 (4), 1432-1448, 2017
512017
Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across the parasite life cycle
C Le Manach, AT Nchinda, T Paquet, D Gonzàlez Cabrera, Y Younis, ...
Journal of medicinal chemistry 59 (21), 9890-9905, 2016
512016
Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels
JVW Becker, L Mtwisha, BG Crampton, S Stoychev, AC van Brummelen, ...
BMC genomics 11, 1-16, 2010
462010
Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels
JVW Becker, L Mtwisha, BG Crampton, S Stoychev, AC van Brummelen, ...
BMC genomics 11, 1-16, 2010
462010
Functional consequences of perturbing polyamine metabolism in the malaria parasite, Plasmodium falciparum
K Clark, J Niemand, S Reeksting, S Smit, AC Van Brummelen, M Williams, ...
Amino Acids 38, 633-644, 2010
462010
Resisting resistance: is there a solution for malaria?
BK Verlinden, A Louw, LM Birkholtz
Expert opinion on drug discovery 11 (4), 395-406, 2016
452016
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