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Paul Mortenson
Paul Mortenson
Astex Pharmaceuticals
Verified email at astx.com
Title
Cited by
Cited by
Year
Diverse, high-quality test set for the validation of protein− ligand docking performance
MJ Hartshorn, ML Verdonk, G Chessari, SC Brewerton, WTM Mooij, ...
Journal of medicinal chemistry 50 (4), 726-741, 2007
6652007
Energy landscapes: from clusters to biomolecules
DJ Wales, JPK Doye, MA Miller, PN Mortenson, TR Walsh
Advances in Chemical Physics 115, 1-111, 2000
3532000
Efficient exploration of chemical space by fragment-based screening
RJ Hall, PN Mortenson, CW Murray
Progress in biophysics and molecular biology 116 (2-3), 82-91, 2014
1632014
Protein− ligand docking against non-native protein conformers
ML Verdonk, PN Mortenson, RJ Hall, MJ Hartshorn, CW Murray
Journal of chemical information and modeling 48 (11), 2214-2225, 2008
1512008
Docking performance of fragments and druglike compounds
ML Verdonk, I Giangreco, RJ Hall, O Korb, PN Mortenson, CW Murray
Journal of medicinal chemistry 54 (15), 5422-5431, 2011
1402011
Assessing the lipophilicity of fragments and early hits
PN Mortenson, CW Murray
Journal of computer-aided molecular design 25 (7), 663-667, 2011
1332011
Energy landscapes, global optimization and dynamics of the polyalanine
PN Mortenson, DJ Wales
The Journal of Chemical Physics 114 (14), 6443-6454, 2001
1012001
Energy landscapes of model polyalanines
PN Mortenson, DA Evans, DJ Wales
The Journal of chemical physics 117 (3), 1363-1376, 2002
1002002
Discovery of 2-(6-{[(6-Fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a Class I Selective Orally Active …
D Moffat, S Patel, F Day, A Belfield, A Donald, M Rowlands, J Wibawa, ...
Journal of medicinal chemistry 53 (24), 8663-8678, 2010
992010
Crystals of binary Lennard-Jones solids
TF Middleton, J Hernández-Rojas, PN Mortenson, DJ Wales
Physical Review B 64 (18), 184201, 2001
972001
DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity
SP East, CB White, O Barker, S Barker, J Bennett, D Brown, EA Boyd, ...
Bioorganic & medicinal chemistry letters 19 (3), 894-899, 2009
892009
Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening
J Neres, ML Brewer, L Ratier, H Botti, A Buschiazzo, PN Edwards, ...
Bioorganic & medicinal chemistry letters 19 (3), 589-596, 2009
852009
Structure–activity and structure–conformation relationships of Aryl propionic acid inhibitors of the kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related …
TD Heightman, JF Callahan, E Chiarparin, JE Coyle, C Griffiths-Jones, ...
Journal of medicinal chemistry 62 (9), 4683-4702, 2019
662019
Fragment-to-lead medicinal chemistry publications in 2018
DA Erlanson, IJP de Esch, W Jahnke, CN Johnson, PN Mortenson
Journal of medicinal chemistry 63 (9), 4430-4444, 2020
652020
Fragment-based discovery of potent and selective DDR1/2 inhibitors
CW Murray, V Berdini, IM Buck, ME Carr, A Cleasby, JE Coyle, JE Curry, ...
ACS medicinal chemistry letters 6 (7), 798-803, 2015
622015
Fragment-to-lead medicinal chemistry publications in 2019
W Jahnke, DA Erlanson, IJP De Esch, CN Johnson, PN Mortenson, ...
Journal of medicinal chemistry 63 (24), 15494-15507, 2020
572020
Fragment-to-lead medicinal chemistry publications in 2017: miniperspective
PN Mortenson, DA Erlanson, IJP De Esch, W Jahnke, CN Johnson
Journal of Medicinal Chemistry 62 (8), 3857-3872, 2018
572018
Pyrrolopyrimidine compounds and their uses
GE Besong, CT Brain, CA Brooks, MS Congreve, C Dagostin, G He, ...
US Patent 8,685,980, 2014
522014
Fragment-to-Lead Medicinal Chemistry Publications in 2016: Miniperspective
CN Johnson, DA Erlanson, W Jahnke, PN Mortenson, DC Rees
Journal of medicinal chemistry 61 (5), 1774-1784, 2017
512017
Fragment-based discovery of 7-azabenzimidazoles as potent, highly selective, and orally active CDK4/6 inhibitors
YS Cho, H Angove, C Brain, CHT Chen, H Cheng, R Cheng, R Chopra, ...
ACS Medicinal Chemistry Letters 3 (6), 445-449, 2012
412012
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