| Epigenetics in human disease and prospects for epigenetic therapy G Egger, G Liang, A Aparicio, PA Jones Nature 429 (6990), 457-463, 2004 | 4277 | 2004 |
| Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells Y Saito, G Liang, G Egger, JM Friedman, JC Chuang, GA Coetzee, ... Cancer cell 9 (6), 435-443, 2006 | 1721 | 2006 |
| DNA-demethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts D Roulois, HL Yau, R Singhania, Y Wang, A Danesh, SY Shen, H Han, ... Cell 162 (5), 961-973, 2015 | 1259 | 2015 |
| The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors KD Robertson, E Uzvolgyi, G Liang, C Talmadge, J Sumegi, FA Gonzales, ... Nucleic acids research 27 (11), 2291-2298, 1999 | 1185 | 1999 |
| Gene body methylation can alter gene expression and is a therapeutic target in cancer X Yang, H Han, DD De Carvalho, FD Lay, PA Jones, G Liang Cancer cell 26 (4), 577-590, 2014 | 1134 | 2014 |
| Rethinking how DNA methylation patterns are maintained PA Jones, G Liang Nature Reviews Genetics 10 (11), 805-811, 2009 | 941 | 2009 |
| Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements G Liang, MF Chan, Y Tomigahara, YC Tsai, FA Gonzales, E Li, PW Laird, ... Molecular and cellular biology 22 (2), 480-491, 2002 | 702 | 2002 |
| DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation TB Miranda, CC Cortez, CB Yoo, G Liang, M Abe, TK Kelly, VE Marquez, ... Molecular cancer therapeutics 8 (6), 1579-1588, 2009 | 694 | 2009 |
| Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome G Liang, JCY Lin, V Wei, C Yoo, JC Cheng, CT Nguyen, DJ Weisenberger, ... Proceedings of the National Academy of Sciences 101 (19), 7357-7362, 2004 | 633 | 2004 |
| Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2′-deoxycytidine CT Nguyen, DJ Weisenberger, M Velicescu, FA Gonzales, JCY Lin, ... Cancer research 62 (22), 6456-6461, 2002 | 510 | 2002 |
| The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2 JM Friedman, G Liang, CC Liu, EM Wolff, YC Tsai, W Ye, X Zhou, ... Cancer research 69 (6), 2623-2629, 2009 | 482 | 2009 |
| Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules TK Kelly, Y Liu, FD Lay, G Liang, BP Berman, PA Jones Genome research 22 (12), 2497-2506, 2012 | 458 | 2012 |
| Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line EN Gal-Yam, G Egger, L Iniguez, H Holster, S Einarsson, X Zhang, JC Lin, ... Proceedings of the National Academy of Sciences 105 (35), 12979-12984, 2008 | 406 | 2008 |
| Preferential response of cancer cells to zebularine JC Cheng, CB Yoo, DJ Weisenberger, J Chuang, C Wozniak, G Liang, ... Cancer cell 6 (2), 151-158, 2004 | 386 | 2004 |
| Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer EM Wolff, HM Byun, HF Han, S Sharma, PW Nichols, KD Siegmund, ... PLoS genetics 6 (4), e1000917, 2010 | 355 | 2010 |
| DNA methylation screening identifies driver epigenetic events of cancer cell survival DD De Carvalho, S Sharma, JS You, SF Su, PC Taberlay, TK Kelly, ... Cancer cell 21 (5), 655-667, 2012 | 327 | 2012 |
| Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells JC Cheng, DJ Weisenberger, FA Gonzales, G Liang, GL Xu, YG Hu, ... Molecular and cellular biology 24 (3), 1270-1278, 2004 | 302 | 2004 |
| Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells Y Saito, JM Friedman, Y Chihara, G Egger, JC Chuang, G Liang Biochemical and biophysical research communications 379 (3), 726-731, 2009 | 297 | 2009 |
| Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2′-deoxycytidine JC Chuang, CB Yoo, JM Kwan, TWH Li, G Liang, AS Yang, PA Jones Molecular cancer therapeutics 4 (10), 1515-1520, 2005 | 272 | 2005 |
| Analysis of gene induction in human fibroblasts and bladder cancer cells exposed to the methylation inhibitor 5-aza-2′-deoxycytidine G Liang, FA Gonzales, PA Jones, TF Orntoft, T Thykjaer Cancer research 62 (4), 961-966, 2002 | 271 | 2002 |
