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Alexandre Beautrait
Alexandre Beautrait
Principal Scientist, Applications Science, at Schrödinger
Adresse e-mail validée de schrodinger.com
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Année
Differential β-Arrestin–Dependent Conformational Signaling and Cellular Responses Revealed by Angiotensin Analogs
B Zimmerman, A Beautrait, B Aguila, R Charles, E Escher, A Claing, ...
Science signaling 5 (221), ra33-ra33, 2012
1682012
A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling
A Beautrait, JS Paradis, B Zimmerman, J Giubilaro, L Nikolajev, ...
Nature Communications 8, 15054, 2017
1422017
Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression
JS Paradis, S Ly, É Blondel-Tepaz, JA Galan, A Beautrait, MGH Scott, ...
Proceedings of the National Academy of Sciences 112 (37), E5160-E5168, 2015
532015
Mapping the Putative G Protein-coupled Receptor (GPCR) Docking Site on GPCR Kinase 2 INSIGHTS FROM INTACT CELL PHOSPHORYLATION AND RECRUITMENT ASSAYS
A Beautrait, KR Michalski, TS Lopez, KM Mannix, DJ McDonald, ...
Journal of Biological Chemistry 289 (36), 25262-25275, 2014
492014
Emerging paradigm of intracellular targeting of G protein-coupled receptors
M Chaturvedi, J Schilling, A Beautrait, M Bouvier, JL Benovic, AK Shukla
Trends in biochemical sciences 43 (7), 533-546, 2018
442018
Quantifying biased signaling in GPCRs using BRET-based biosensors
Y Namkung, O Radresa, S Armando, D Devost, A Beautrait, C Le Gouill, ...
Methods 92, 5-10, 2016
442016
Enhancing Hit Discovery in Virtual Screening through Absolute Protein–Ligand Binding Free-Energy Calculations
W Chen, D Cui, SV Jerome, M Michino, EB Lenselink, DJ Huggins, ...
Journal of Chemical Information and Modeling, 2023
302023
SHEF: a vHTS geometrical filter using coefficients of spherical harmonic molecular surfaces
W Cai, J Xu, X Shao, V Leroux, A Beautrait, B Maigret
Journal of molecular modeling 14 (5), 393-401, 2008
252008
Multiple-step virtual screening using VSM-G: overview and validation of fast geometrical matching enrichment
A Beautrait, V Leroux, M Chavent, L Ghemtio, MD Devignes, ...
Journal of molecular modeling 14 (2), 135-148, 2008
252008
A fast surface-matching procedure for protein–ligand docking
MEB Yamagishi, NF Martins, G Neshich, W Cai, X Shao, A Beautrait, ...
Journal of Molecular Modeling 12 (6), 965-972, 2006
202006
Identification of allosteric inhibitors against active caspase-6
A Tubeleviciute-Aydin, A Beautrait, J Lynham, G Sharma, A Gorelik, ...
Scientific reports 9 (1), 1-19, 2019
192019
Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assay
K Normandin, JF Lavallée, M Futter, A Beautrait, J Duchaine, S Guiral, ...
Scientific reports 6 (1), 1-20, 2016
182016
Induced-Fit Docking Enables Accurate Free Energy Perturbation Calculations in Homology Models
T Xu, K Zhu, A Beautrait, J Vendome, KW Borrelli, R Abel, RA Friesner, ...
Journal of Chemical Theory and Computation, 2022
112022
Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen
J Giubilaro, DA Schuetz, TM Stepniewski, Y Namkung, E Khoury, ...
Nature Communications 12 (1), 1-16, 2021
82021
Beta-arrestins operate an on/off control switch for focal adhesion kinase activity
RA Alexander, I Lot, K Saha, G Abadie, M Lambert, E Decosta, ...
Cellular and Molecular Life Sciences, 1-21, 2020
82020
Induced fit in liver X receptor beta: A molecular dynamics‐based investigation
A Beautrait, AS Karaboga, M Souchet, B Maigret
Proteins: Structure, Function, and Bioinformatics 72 (3), 873-882, 2008
82008
Développement et validation de la plateforme de criblage virtuel VSM-G et étude du domaine FAT de la kinase d'adhérence focale FAK
A Beautrait
Université Henri Poincaré-Nancy I, 2008
72008
Arrestin biosensor
M Bouvier, PG Charest, C LeGouill, A Beautrait, SA Laporte, ...
US Patent 8,883,486, 2014
52014
Do natural silks make good engineering materials?
NA Morrison, FI Bell, A Beautrait, J Ritchie, C Smith, IJ McEwen, C Viney
MRS Online Proceedings Library (OPL) 823, 2004
42004
Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors
M Michino, A Beautrait, NA Boyles, A Nadupalli, A Dementiev, S Sun, ...
ACS Bio & Med Chem Au, 2023
2023
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