| PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase B Adhikari, J Bozilovic, M Diebold, JD Schwarz, J Hofstetter, M Schröder, ... Nature Chemical Biology, 1-10, 2020 | 86 | 2020 |
| The Kinase Chemogenomic Set (KCGS): An open science resource for kinase vulnerability identification CI Wells, H Al-Ali, DM Andrews, CRM Asquith, AD Axtman, M Chung, ... bioRxiv, 2019 | 78 | 2019 |
| Furo[3,2‐b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway V Němec, M Hylsová, L Maier, J Flegel, S Sievers, S Ziegler, M Schröder, ... Angewandte Chemie 131 (4), 1074-1078, 2019 | 49 | 2019 |
| An Unusual Binding Model of the Methyl 9-Anilinothiazolo[5,4-f] quinazoline-2-carbimidates (EHT 1610 and EHT 5372) Confers High Selectivity for Dual-Specificity … A Chaikuad, J Diharce, M Schröder, A Foucourt, B Leblond, ... Journal of Medicinal Chemistry 59 (22), 10315-10321, 2016 | 48 | 2016 |
| Leveraging compound promiscuity to identify targetable cysteines within the kinome S Rao, D Gurbani, G Du, RA Everley, CM Browne, A Chaikuad, L Tan, ... Cell chemical biology 26 (6), 818-829. e9, 2019 | 45 | 2019 |
| Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2 BT Berger, M Amaral, DB Kokh, A Nunes-Alves, D Musil, T Heinrich, ... Cell Chemical Biology, 2021 | 44 | 2021 |
| New pyrido [3, 4-g] quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis H Tazarki, W Zeinyeh, YJ Esvan, S Knapp, D Chatterjee, M Schröder, ... European journal of medicinal chemistry 166, 304-317, 2019 | 38 | 2019 |
| Structural insights into plasticity and discovery of remdesivir metabolite GS-441524 binding in SARS-CoV-2 macrodomain X Ni, M Schröder, V Olieric, ME Sharpe, V Hernandez-Olmos, ... ACS Medicinal Chemistry Letters, 2021 | 37 | 2021 |
| p63 uses a switch-like mechanism to set the threshold for induction of apoptosis J Gebel, M Tuppi, A Chaikuad, K Hötte, M Schröder, L Schulz, F Löhr, ... Nature Chemical Biology, 1-9, 2020 | 32 | 2020 |
| DFG-1 residue controls inhibitor binding mode and affinity providing a basis for rational design of kinase inhibitor selectivity M Schröder, AN Bullock, O Fedorov, F Bracher, A Chaikuad, S Knapp Journal of Medicinal Chemistry, 2020 | 32 | 2020 |
| Structures of PGAM5 provide insight into active site plasticity and multimeric assembly A Chaikuad, P Filippakopoulos, SR Marcsisin, S Picaud, M Schröder, ... Structure 25 (7), 1089-1099. e3, 2017 | 32 | 2017 |
| Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors S Röhm, BT Berger, M Schröder, A Chaikuad, R Winkel, KFW Hekking, ... Journal of Medicinal Chemistry 62 (23), 10757-10782, 2019 | 25 | 2019 |
| Hepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication N Abeywickrama-Samarakoon, JC Cortay, C Sureau, S Müller, D Alfaiate, ... Nature communications 11 (1), 1-13, 2020 | 24 | 2020 |
| Image based annotation of Chemogenomic Libraries for Phenotypic Screening A Tjaden, A Chaikuad, E Kowarz, R Marschalek, S Knapp, M Schröder, ... Preprints, 2022 | 22 | 2022 |
| Demonstrating Ligandability of the LC3A and LC3B Adapter Interface M Hartmann, J Huber, JS Kramer, J Heering, L Pietsch, H Stark, ... Journal of Medicinal Chemistry, 2021 | 22 | 2021 |
| Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities M Schröder, L Tan, J Wang, Y Liang, NS Gray, S Knapp, A Chaikuad Cell Chemical Biology 27 (10), 1285-1295. e4, 2020 | 19 | 2020 |
| Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK M Forster, XJ Liang, M Schröder, S Gerstenecker, A Chaikuad, S Knapp, ... International Journal of Molecular Sciences 21 (23), 9269, 2020 | 17 | 2020 |
| A triple farnesoid X receptor and peroxisome proliferator-activated receptor α/δ activator reverses hepatic fibrosis in diet-induced NASH in mice P Heitel, G Faudone, M Helmstädter, J Schmidt, A Kaiser, A Tjaden, ... Communications Chemistry 3 (1), 1-16, 2020 | 14 | 2020 |
| Selective targeting of the αC-and DFG-out pocket in p38 MAPK S Röhm, M Schröder, JE Dwyer, CS Widdowson, A Chaikuad, BT Berger, ... European Journal of Medicinal Chemistry, 112721, 2020 | 13 | 2020 |
| HighVia—A Flexible Live-Cell High-Content Screening Pipeline to Assess Cellular Toxicity A Howarth, M Schröder, RC Montenegro, DH Drewry, S Heba, V Millar, ... SLAS DISCOVERY: Advancing the Science of Drug Discovery, 2472555220923979, 2020 | 12 | 2020 |
Stefan KnappUniversity of FrankfurtVerified email at pharmchem.uni-frankfurt.de
