GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions S Brun, E Bestion, E Raymond, F Bassissi, ZM Jilkova, S Mezouar, ... Autophagy 18 (3), 678-694, 2022 | 41 | 2022 |
Evolutionary diversification of protein–protein interactions by interface add-ons MG Plach, F Semmelmann, F Busch, M Busch, L Heizinger, VH Wysocki, ... Proceedings of the National Academy of Sciences 114 (40), E8333-E8342, 2017 | 24 | 2017 |
MicroScale Thermophoresis as a tool to study protein-peptide interactions in the context of large eukaryotic protein complexes MG Plach, K Grasser, T Schubert Bio-protocol 7 (23), e2632-e2632, 2017 | 22 | 2017 |
Long-term persistence of bi-functionality contributes to the robustness of microbial life through exaptation MG Plach, B Reisinger, R Sterner, R Merkl PLoS genetics 12 (1), e1005836, 2016 | 20 | 2016 |
Biophysical characterization of aptamer-target interactions M Plach, T Schubert Aptamers in Biotechnology, 1-15, 2020 | 19 | 2020 |
Conversion of anthranilate synthase into isochorismate synthase: implications for the evolution of chorismate‐utilizing enzymes MG Plach, P Löffler, R Merkl, R Sterner Angewandte Chemie International Edition 54 (38), 11270-11274, 2015 | 14 | 2015 |
AGeNNT: annotation of enzyme families by means of refined neighborhood networks F Kandlinger, MG Plach, R Merkl BMC bioinformatics 18, 1-13, 2017 | 9 | 2017 |
Assessing in silico the recruitment and functional spectrum of bacterial enzymes from secondary metabolism V Veprinskiy, L Heizinger, MG Plach, R Merkl BMC Evolutionary Biology 17, 1-15, 2017 | 3 | 2017 |
In Silico Driven Prediction of MAPK14 Off-Targets Reveals Unrelated Proteins with High Accuracy F Kaiser, MG Plach, C Leberecht, T Schubert, VJ Haupt bioRxiv, 2020.07. 24.219071, 2020 | 2 | 2020 |
Multi-parameter formulation development for an HIV-vaccine protein with direct validation of epitope binding integrity and stoichiometry C Popp, P Schramm, R Wagner, D Peterhoff, C Battle, C Kleusch, ... bioRxiv, 2020.11. 30.403873, 2020 | 1 | 2020 |
Umwandlung einer Anthranilatsynthase in eine Isochorismatsynthase: Implikationen für die Evolution von Chorismat‐umsetzenden Enzymen MG Plach, P Löffler, R Merkl, R Sterner Angewandte Chemie 127 (38), 11423-11427, 2015 | 1 | 2015 |
SAXS/MC studies of the mixed-folded protein Cdt1 reveal monomeric, folded over conformations KP Smith, S Chakravarthy, A Rahi, M Chakraborty, KM Vosberg, M Tonelli, ... bioRxiv, 2024 | | 2024 |
Enhancement of complement-dependent cytotoxicity by linking factor-H derived SCRs 19-20 to CD20 antibodies H Stoiber, L Prantl, P Heider, L Bergmeister, JP Bohn, D Wolf, Z Banki, ... | | 2023 |
Impact of single mutations on binding kinetics of triplex forming oligos revealed by fluorescence proximity sensing in heliX® biosensor V Molkenthin, D Baumstark, T Schubert, G Längst, MG Plach bioRxiv, 2022.11. 21.517309, 2022 | | 2022 |
Focus Your Screening Library: Rapid Identification of Novel PDE2 Inhibitors with in silico Driven Library Prioritization and MicroScale Thermophoresis F Kaiser, MG Plach, T Schubert, VJ Haupt bioRxiv, 2020.04. 22.021360, 2020 | | 2020 |
Evolution of substrate specificity and protein-protein interactions in three enzyme superfamilies M Plach | | 2017 |