| Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation J Rihel, DA Prober, A Arvanites, K Lam, S Zimmerman, S Jang, ... Science 327 (5963), 348-351, 2010 | 773 | 2010 |
| A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS YM Yang, SK Gupta, KJ Kim, BE Powers, A Cerqueira, BJ Wainger, ... Cell stem cell 12 (6), 713-726, 2013 | 329 | 2013 |
| Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication JP Annes, JH Ryu, K Lam, PJ Carolan, K Utz, J Hollister-Lock, ... Proceedings of the National Academy of Sciences, 2012 | 167 | 2012 |
| Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway B Blum, AN Roose, O Barrandon, R Maehr, AC Arvanites, LS Davidow, ... Elife 3, e02809, 2014 | 134 | 2014 |
| A screen for regulators of survival of motor neuron protein levels NR Makhortova, M Hayhurst, A Cerqueira, AD Sinor-Anderson, WN Zhao, ... Nature Chemical Biology 7 (8), 544-552, 2011 | 97 | 2011 |
| Identification and characterization of inhibitors of bacterial enoyl-acyl carrier protein reductase LL Ling, J Xian, S Ali, B Geng, J Fan, DM Mills, AC Arvanites, H Orgueira, ... Antimicrobial agents and chemotherapy 48 (5), 1541-1547, 2004 | 74 | 2004 |
| Glucocorticoid Compounds Modify Smoothened Localization and Hedgehog Pathway Activity Y Wang, L Davidow, AC Arvanites, J Blanchard, K Lam, K Xu, V Oza, ... Chemistry & Biology 19 (8), 972-982, 2012 | 72 | 2012 |
| Pyrimidine-2, 4, 6-trione derivatives and their inhibition of mutant SOD1-dependent protein aggregation. Toward a treatment for amyotrophic lateral sclerosis G Xia, R Benmohamed, J Kim, AC Arvanites, RI Morimoto, RJ Ferrante, ... Journal of medicinal chemistry 54 (7), 2409-2421, 2011 | 51 | 2011 |
| Selective Identification of Hedgehog Pathway Antagonists By Direct Analysis of Smoothened Ciliary Translocation Y Wang, AC Arvanites, L Davidow, J Blanchard, K Lam, JW Yoo, S Coy, ... ACS Chemical Biology, 2012 | 49 | 2012 |
| Identification of compounds protective against G93A-SOD1 toxicity for the treatment of amyotrophic lateral sclerosis R Benmohamed, AC Arvanites, J Kim, RJ Ferrante, RB Silverman, ... Amyotrophic Lateral Sclerosis 12 (2), 87-96, 2011 | 42 | 2011 |
| Modeling of the mechanism of nucleophilic aromatic substitution of fungicide chlorothalonil by glutathione AC Arvanites, DW Boerth Journal of Molecular Modeling 7 (7), 245-256, 2001 | 38 | 2001 |
| Cyclohexane 1, 3-diones and their inhibition of mutant SOD1-dependent protein aggregation and toxicity in PC12 cells W Zhang, R Benmohamed, AC Arvanites, RI Morimoto, RJ Ferrante, ... Bioorganic & Medicinal Chemistry, 2011 | 36 | 2011 |
| Repurposing cAMP-modulating medications to promote β-cell replication Z Zhao, YS Low, NA Armstrong, JH Ryu, SA Sun, AC Arvanites, ... Molecular endocrinology 28 (10), 1682-1697, 2014 | 34 | 2014 |
| Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis T Chen, R Benmohamed, AC Arvanites, HR Ranaivo, RI Morimoto, ... Bioorganic & medicinal chemistry 19 (1), 613-622, 2011 | 28 | 2011 |
| Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons YC Cheng, A Snavely, LB Barrett, X Zhang, C Herman, DJ Frost, P Riva, ... Cell reports 36 (10), 2021 | 21 | 2021 |
| Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer SJF Cronin, S Rao, MA Tejada, BL Turnes, S Licht-Mayer, T Omura, ... Science translational medicine 14 (660), eabj1531, 2022 | 14 | 2022 |
| Treatment of amyotrophic lateral sclerosis DR Kirsch, R Benmohamed, AC Arvanites, RI Morimoto, T Chen, ... US Patent 10,167,263, 2019 | 6 | 2019 |
| Antibiotic tetrahydro-beta-carboline derivatives T Opperman, A Arvanites, J Pinto, Y Xiang, S Ali, B Geng, M Ashwell, ... US Patent App. 10/554,756, 2006 | 6 | 2006 |
| Antibacterial fab i inhibitors D Moir, Y Xiang, A Arvanites, S Ali, B Geng, M Ashwell, H Orgueira, ... US Patent App. 10/542,351, 2007 | 5 | 2007 |
| Nucleophilic aromatic substitution in chlorinated aromatic systems with a glutathione thiolate model DW Boerth, AC Arvanites Journal of Physical Organic Chemistry 30 (7), e3640, 2017 | 4 | 2017 |
Lee L. RubinProfessor of Stem Cell and Regenerative Biology, Harvard UniversityAdresse e-mail validée de harvard.edu
