William Michael Marsiglia
William Michael Marsiglia
Adresse e-mail validée de mssm.edu
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Defining substrate and blocker activity of alanine-serine-cysteine transporter 2 (ASCT2) ligands with novel serine analogs
T Albers, W Marsiglia, T Thomas, A Gameiro, C Grewer
Molecular pharmacology 81 (3), 356-365, 2012
452012
Two FGF receptor kinase molecules act in concert to recruit and transphosphorylate phospholipase Cγ
Z Huang, WM Marsiglia, UB Roy, N Rahimi, D Ilghari, H Wang, H Chen, ...
Molecular cell 61 (1), 98-110, 2016
272016
Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases
H Chen, WM Marsiglia, MK Cho, Z Huang, J Deng, SP Blais, W Gai, ...
Elife 6, e21137, 2017
232017
Multiple frequency saturation pulses reduce CEST acquisition time for quantifying conformational exchange in biomolecules
M Leninger, WM Marsiglia, A Jerschow, NJ Traaseth
Journal of biomolecular NMR 71 (1), 19-30, 2018
102018
Structural and kinetic insights into stimulation of RppH-dependent RNA degradation by the metabolic enzyme DapF
A Gao, N Vasilyev, DJ Luciano, R Levenson-Palmer, J Richards, ...
Nucleic acids research 46 (13), 6841-6856, 2018
82018
Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation
L Chen, WM Marsiglia, H Chen, J Katigbak, H Erdjument-Bromage, ...
Nature Chemical Biology 16 (3), 267-277, 2020
52020
Structural basis for the action of the drug trametinib at KSR-bound MEK
ZM Khan, AM Real, WM Marsiglia, A Chow, ME Duffy, JR Yerabolu, ...
Nature 588 (7838), 509-514, 2020
32020
A Conserved Allosteric Pathway in Tyrosine Kinase Regulation
WM Marsiglia, J Katigbak, S Zheng, M Mohammadi, Y Zhang, NJ Traaseth
Structure 27 (8), 1308-1315. e3, 2019
32019
A CURE Biochemistry Laboratory Module to Study Protein–Protein Interactions by NMR Spectroscopy
WM Marsiglia, R Qamra, KM Jackson, NJ Traaseth
Journal of Chemical Education 97 (2), 437-442, 2020
22020
TRAMETINIB PROMOTES MEK BINDING TO THE RAF-FAMILY PSEUDOKINASE KSR
ZM Khan, AM Real, WM Marsiglia, A Chow, ME Duffy, JR Yerabolu
CANCER DISCOVERY 10 (11), 1624-1624, 2020
2020
Ploidy Leads a Molecular Motor to Walk Different Paths to Drug Resistance
AM Real, WM Marsiglia, AC Dar
Cell Chemical Biology 27 (7), 770-772, 2020
2020
Elucidating the Activating Mechanism of Gatekeeper Mutations on Receptor Tyrosine Kinases
A Besch, W Marsiglia, M Mohammadi, Y Zhang, N Traaseth
Biophysical Journal 118 (3), 53a, 2020
2020
Allostery and Conformational Dynamics in Tyrosine Kinase Regulation
W Marsiglia, J Katigbak, S Zheng, M Mohammadi, Y Zhang, N Traaseth
Biophysical Journal 118 (3), 522a, 2020
2020
Characterization of Disease Causing Mutations Associated with FGF Receptor Tyrosine Kinases using NMR Spectroscopy
WM Marsiglia, H Chen, M Cho, M Mohammadi, NJ Traaseth
Biophysical Journal 112 (3), 64a, 2017
2017
NMR Experiments on Wild-Type and Mutant Fibroblast Growth Factor Receptor Kinases Reveal Conformational Dynamics Associated with Enzyme Activation
W Marsiglia, H Chen, M Cho, M Mohammadi, NJ Traaseth
Biophysical Journal 110 (3), 220a, 2016
2016
Supplemental Information Two FGFR Kinase Molecules Act in Concert to Recruit and Transphosphorylate PLCγ
Z Huang, WM Marsiglia, UB Roy, N Rahimi, D Ilghari, H Wang, H Chen, ...
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