Patrick K Tumwebaze
Patrick K Tumwebaze
Molecular Parasitology Research lab Manager, Infectious Diseases Research Collaboration, Uganda
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Changing prevalence of potential mediators of aminoquinoline, antifolate, and artemisinin resistance across Uganda
V Asua, MD Conrad, O Aydemir, M Duvalsaint, J Legac, E Duarte, ...
The Journal of infectious diseases 223 (6), 985-994, 2021
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance
LA Kirkman, W Zhan, J Visone, A Dziedziech, PK Singh, H Fan, X Tong, ...
Proceedings of the National Academy of Sciences 115 (29), E6863-E6870, 2018
Lack of artemisinin resistance in Plasmodium falciparum in Uganda based on parasitological and molecular assays
RA Cooper, MD Conrad, QD Watson, SJ Huezo, H Ninsiima, ...
Antimicrobial agents and chemotherapy 59 (8), 5061-5064, 2015
The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC
R Verity, O Aydemir, NF Brazeau, OJ Watson, NJ Hathaway, ...
Nature communications 11 (1), 2107, 2020
Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from Ugandan children
P Tumwebaze, MD Conrad, A Walakira, N LeClair, O Byaruhanga, ...
Antimicrobial agents and chemotherapy 59 (6), 3018-3030, 2015
Changing antimalarial drug sensitivities in Uganda
SA Rasmussen, FG Ceja, MD Conrad, PK Tumwebaze, O Byaruhanga, ...
Antimicrobial agents and chemotherapy 61 (12), 10.1128/aac. 01516-17, 2017
Changing antimalarial drug resistance patterns identified by surveillance at three sites in Uganda
P Tumwebaze, S Tukwasibwe, A Taylor, M Conrad, E Ruhamyankaka, ...
The Journal of infectious diseases 215 (4), 631-635, 2017
Evolution of partial resistance to artemisinins in malaria parasites in Uganda
MD Conrad, V Asua, S Garg, D Giesbrecht, K Niaré, S Smith, ...
New England Journal of Medicine 389 (8), 722-732, 2023
Tools for mass screening of G6PD deficiency: validation of the WST8/1-methoxy-PMS enzymatic assay in Uganda
M De Niz, AC Eziefula, L Othieno, E Mbabazi, D Nabukeera, ...
Malaria journal 12, 1-11, 2013
Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda
PK Tumwebaze, MD Conrad, M Okitwi, S Orena, O Byaruhanga, T Katairo, ...
Nature communications 13 (1), 6353, 2022
Drug susceptibility of Plasmodium falciparum in eastern Uganda: a longitudinal phenotypic and genotypic study
PK Tumwebaze, T Katairo, M Okitwi, O Byaruhanga, S Orena, V Asua, ...
The Lancet Microbe 2 (9), e441-e449, 2021
The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance
JM Murithi, C Pascal, J Bath, X Boulenc, NF Gnädig, CFA Pasaje, ...
Science translational medicine 13 (603), eabg6013, 2021
Validation of the ligase detection reaction fluorescent microsphere assay for the detection of Plasmodium falciparum resistance mediating polymorphisms in Uganda
S Nankoberanyi, GW Mbogo, NP LeClair, MD Conrad, P Tumwebaze, ...
Malaria journal 13, 1-5, 2014
Potent antimalarials with development potential identified by structure-guided computational optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series
MJ Palmer, X Deng, S Watts, G Krilov, A Gerasyuto, S Kokkonda, ...
Journal of medicinal chemistry 64 (9), 6085-6136, 2021
Impact of Intermittent Preventive Treatment During Pregnancy on Plasmodium falciparum Drug Resistance–Mediating Polymorphisms in Uganda
MD Conrad, D Mota, M Foster, S Tukwasibwe, J Legac, P Tumwebaze, ...
The Journal of infectious diseases 216 (8), 1008-1017, 2017
Intermittent preventive treatment with dihydroartemisinin-piperaquine in Ugandan schoolchildren selects for Plasmodium falciparum transporter polymorphisms that modify drug …
JI Nankabirwa, MD Conrad, J Legac, S Tukwasibwe, P Tumwebaze, ...
Antimicrobial agents and chemotherapy 60 (10), 5649-5654, 2016
Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors
W Zhan, J Visone, T Ouellette, JC Harris, R Wang, H Zhang, PK Singh, ...
Journal of medicinal chemistry 62 (13), 6137-6145, 2019
Fitness Consequences of Plasmodium falciparum pfmdr1 Polymorphisms Inferred from Ex Vivo Culture of Ugandan Parasites
E Ochong, PK Tumwebaze, O Byaruhanga, B Greenhouse, PJ Rosenthal
Antimicrobial agents and chemotherapy 57 (9), 4245-4251, 2013
Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti‐malaria Activity in Humanized Mice
W Zhan, H Zhang, J Ginn, A Leung, YJ Liu, M Michino, A Toita, ...
Angewandte Chemie 133 (17), 9365-9369, 2021
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183
LE de Vries, PAM Jansen, C Barcelo, J Munro, JMJ Verhoef, CFA Pasaje, ...
Nature communications 13 (1), 2158, 2022
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