| Darwinian evolution can follow only very few mutational paths to fitter proteins DM Weinreich, NF Delaney, MA DePristo, DL Hartl science 312 (5770), 111-114, 2006 | 1501 | 2006 |
| Perspective: sign epistasis and genetic costraint on evolutionary trajectories DM Weinreich, RA Watson, L Chao Evolution 59 (6), 1165-1174, 2005 | 780 | 2005 |
| Missense meanderings in sequence space: a biophysical view of protein evolution MA DePristo, DM Weinreich, DL Hartl Nature Reviews Genetics 6 (9), 678-687, 2005 | 725 | 2005 |
| Empirical fitness landscapes reveal accessible evolutionary paths FJ Poelwijk, DJ Kiviet, DM Weinreich, SJ Tans Nature 445 (7126), 383-386, 2007 | 608 | 2007 |
| Should evolutionary geneticists worry about higher-order epistasis? DM Weinreich, Y Lan, CS Wylie, RB Heckendorn Current opinion in genetics & development 23 (6), 700-707, 2013 | 302 | 2013 |
| Stepwise acquisition of pyrimethamine resistance in the malaria parasite ER Lozovsky, T Chookajorn, KM Brown, M Imwong, PJ Shaw, ... Proceedings of the National Academy of Sciences 106 (29), 12025-12030, 2009 | 292 | 2009 |
| The interface of protein structure, protein biophysics, and molecular evolution DA Liberles, SA Teichmann, I Bahar, U Bastolla, J Bloom, ... Protein Science 21 (6), 769-785, 2012 | 238 | 2012 |
| Rapid evolutionary escape by large populations from local fitness peaks is likely in nature DM Weinreich, L Chao Evolution 59 (6), 1175-1182, 2005 | 238 | 2005 |
| Causes and evolutionary significance of genetic convergence PA Christin, DM Weinreich, G Besnard Trends in Genetics 26 (9), 400-405, 2010 | 217 | 2010 |
| Patterns and mechanisms of genetic and phenotypic differentiation in marine microbes MF Polz, DE Hunt, SP Preheim, DM Weinreich Philosophical Transactions of the Royal Society B: Biological Sciences 361 …, 2006 | 211 | 2006 |
| The evolution of phenotypic correlations and “developmental memory” RA Watson, GP Wagner, M Pavlicev, DM Weinreich, R Mills Evolution 68 (4), 1124-1138, 2014 | 143 | 2014 |
| Contrasting patterns of nonneutral evolution in proteins encoded in nuclear and mitochondrial genomes DM Weinreich, DM Rand Genetics 156 (1), 385-399, 2000 | 131 | 2000 |
| Adaptive landscape by environment interactions dictate evolutionary dynamics in models of drug resistance CB Ogbunugafor, CS Wylie, I Diakite, DM Weinreich, DL Hartl PLoS computational biology 12 (1), e1004710, 2016 | 95 | 2016 |
| The influence of higher-order epistasis on biological fitness landscape topography DM Weinreich, Y Lan, J Jaffe, RB Heckendorn Journal of statistical physics 172, 208-225, 2018 | 77 | 2018 |
| The age of nonsynonymous and synonymous mutations in animal mtDNA and implications for the mildly deleterious theory R Nielsen, DM Weinreich Genetics 153 (1), 497-506, 1999 | 74 | 1999 |
| Widespread genetic exchange among terrestrial bacteriophages OK Silander, DM Weinreich, KM Wright, KJ O'Keefe, CU Rang, PE Turner, ... Proceedings of the National Academy of Sciences 102 (52), 19009-19014, 2005 | 73 | 2005 |
| Enzyme efficiency but not thermostability drives cefotaxime resistance evolution in TEM-1 β-lactamase JL Knies, F Cai, DM Weinreich Molecular biology and evolution 34 (5), 1040-1054, 2017 | 70 | 2017 |
| Measuring epistasis in fitness landscapes: The correlation of fitness effects of mutations L Ferretti, B Schmiegelt, D Weinreich, A Yamauchi, Y Kobayashi, F Tajima, ... Journal of theoretical biology 396, 132-143, 2016 | 70 | 2016 |
| Quantitative description of a protein fitness landscape based on molecular features MR Meini, PE Tomatis, DM Weinreich, AJ Vila Molecular biology and evolution 32 (7), 1774-1787, 2015 | 69 | 2015 |
| Mutational reversions during adaptive protein evolution MA DePristo, DL Hartl, DM Weinreich Molecular biology and evolution 24 (8), 1608-1610, 2007 | 59 | 2007 |
