A presenilin-1/γ-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions P Marambaud, J Shioi, G Serban, A Georgakopoulos, S Sarner, V Nagy, ... The EMBO journal 21 (8), 1948-1956, 2002 | 908 | 2002 |
Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide MA Pappolla, M Sos, RA Omar, RJ Bick, DLM Hickson-Bick, RJ Reiter, ... Journal of Neuroscience 17 (5), 1683-1690, 1997 | 517 | 1997 |
Inhibitory Activity on Amyloid-β Aggregation and Antioxidant Properties of Crocus sativus Stigmas Extract and Its Crocin Constituents MA Papandreou, CD Kanakis, MG Polissiou, S Efthimiopoulos, ... Journal of agricultural and food chemistry 54 (23), 8762-8768, 2006 | 443 | 2006 |
Presenilin-1 forms complexes with the cadherin/catenin cell–cell adhesion system and is recruited to intercellular and synaptic contacts A Georgakopoulos, P Marambaud, S Efthimiopoulos, J Shioi, W Cui, ... Molecular cell 4 (6), 893-902, 1999 | 275 | 1999 |
Memory enhancing effects of saffron in aged mice are correlated with antioxidant protection MA Papandreou, M Tsachaki, S Efthimiopoulos, P Cordopatis, FN Lamari, ... Behavioural brain research 219 (2), 197-204, 2011 | 264 | 2011 |
Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex L Baki, P Marambaud, S Efthimiopoulos, A Georgakopoulos, P Wen, ... Proceedings of the National Academy of Sciences 98 (5), 2381-2386, 2001 | 233 | 2001 |
BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid β (Aβ) production A Fotinopoulou, M Tsachaki, M Vlavaki, A Poulopoulos, A Rostagno, ... Journal of Biological Chemistry 280 (35), 30768-30772, 2005 | 141 | 2005 |
A novel Polish presenilin-1 mutation (P117L) is associated with familial Alzheimer's disease and leads to death as early as the age of 28 years T Wisniewski, WK Dowjat, JD Buxbaum, O Khorkova, S Efthimiopoulos, ... Neuroreport 9 (2), 217-221, 1998 | 127 | 1998 |
Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains GA Elder, N Tezapsidis, J Carter, J Shioi, C Bouras, HC Li, JM Johnston, ... Journal of neuroscience research 45 (3), 308-320, 1996 | 113 | 1996 |
The chondroitin sulfate attachment site of appican is formed by splicing out exon 15 of the amyloid precursor gene MN Pangalos, S Efthimiopoulos, J Shioi, NK Robakis Journal of Biological chemistry 270 (18), 10388-10391, 1995 | 97 | 1995 |
Cholinergic agonists stimulate secretion of soluble full-length amyloid precursor protein in neuroendocrine cells. S Efthimiopoulos, D Vassilacopoulou, JA Ripellino, N Tezapsidis, ... Proceedings of the National Academy of Sciences 93 (15), 8046-8050, 1996 | 81 | 1996 |
Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization LM Refolo, K Sambamurti, S Efthimiopoulos, MA Pappolla, NK Robakis Journal of neuroscience research 40 (5), 694-706, 1995 | 73 | 1995 |
Enrichment of presenilin 1 peptides in neuronal large dense‐core and somatodendritic clathrin‐coated vesicles S Efthimiopoulos, E Floor, A Georgakopoulos, J Shioi, W Cui, ... Journal of neurochemistry 71 (6), 2365-2372, 1998 | 66 | 1998 |
Distinct Secretases, a Cysteine Protease and a Serine Protease, Generate the C Termini of Amyloid β‐Proteins Aβ1‐40 and Aβ1‐42, Respectively ME Figueiredo‐Pereira, S Efthimiopoulos, N Tezapsidis, A Buku, J Ghiso, ... Journal of neurochemistry 72 (4), 1417-1422, 1999 | 62 | 1999 |
Intracellular cyclic AMP inhibits constitutive and phorbol ester‐stimulated secretory cleavage of amyloid precursor protein S Efthimiopoulos, S Punj, V Manolopoulos, M Pangalos, GP Wang, ... Journal of neurochemistry 67 (2), 872-875, 1996 | 61 | 1996 |
Expression of mDab1 promotes the stability and processing of amyloid precursor protein and this effect is counteracted by X11α L Parisiadou, S Efthimiopoulos Neurobiology of aging 28 (3), 377-388, 2007 | 56 | 2007 |
Abeta (1–40)-induced secretion of matrix metalloproteinase-9 results in sAPPα release by association with cell surface APP AA Talamagas, S Efthimiopoulos, EC Tsilibary, ME Figueiredo-Pereira, ... Neurobiology of disease 28 (3), 304-315, 2007 | 53 | 2007 |
Appican expression induces morphological changes in C6 glioma cells and promotes adhesion of neural cells to the extracellular matrix A Wu, MN Pangalos, S Efthimiopoulos, J Shioi, NK Robakis Journal of Neuroscience 17 (13), 4987-4993, 1997 | 49 | 1997 |
Characterization of appican, the chondroitin sulfate proteoglycan form of the Alzheimer amyloid precursor protein MN Pangalos, J Shioi, S Efthimiopoulos, A Wu, NK Robakis Neurodegeneration 5 (4), 445-451, 1996 | 49 | 1996 |
Homer2 and Homer3 interact with amyloid precursor protein and inhibit Aβ production L Parisiadou, I Bethani, V Michaki, K Krousti, G Rapti, S Efthimiopoulos Neurobiology of disease 30 (3), 353-364, 2008 | 46 | 2008 |