|Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade|
KE Pauken, MA Sammons, PM Odorizzi, S Manne, J Godec, O Khan, ...
Science 354 (6316), 1160-1165, 2016
|Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis|
L Durant, WT Watford, HL Ramos, A Laurence, G Vahedi, L Wei, ...
Immunity 32 (5), 605-615, 2010
|Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5|
XP Yang, K Ghoreschi, SM Steward-Tharp, J Rodriguez-Canales, J Zhu, ...
Nature immunology 12 (3), 247-254, 2011
|Early Th1 cell differentiation is marked by a Tfh cell-like transition|
S Nakayamada, Y Kanno, H Takahashi, D Jankovic, KT Lu, TA Johnson, ...
Immunity 35 (6), 919-931, 2011
|BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis|
R Roychoudhuri, K Hirahara, K Mousavi, D Clever, CA Klebanoff, ...
Nature 498 (7455), 506-510, 2013
|Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity|
Y Kanno, G Vahedi, K Hirahara, K Singleton, JJ O'Shea
Annual review of immunology 30, 707-731, 2012
|STATs shape the active enhancer landscape of T cell populations|
G Vahedi, H Takahashi, S Nakayamada, H Sun, V Sartorelli, Y Kanno, ...
Cell 151 (5), 981-993, 2012
|Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation|
L Wei, G Vahedi, HW Sun, WT Watford, H Takatori, HL Ramos, ...
Immunity 32 (6), 840-851, 2010
|Genomic views of STAT function in CD4+ T helper cell differentiation|
JJ O'shea, R Lahesmaa, G Vahedi, A Laurence, Y Kanno
Nature reviews Immunology 11 (4), 239-250, 2011
|Super-enhancers delineate disease-associated regulatory nodes in T cells|
G Vahedi, Y Kanno, Y Furumoto, K Jiang, SCJ Parker, MR Erdos, ...
Nature 520 (7548), 558-562, 2015
|Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1|
K Hirahara, K Ghoreschi, XP Yang, H Takahashi, A Laurence, G Vahedi, ...
Immunity 36 (6), 1017-1030, 2012
|BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones|
T Kanno, Y Kanno, G LeRoy, E Campos, HW Sun, SR Brooks, G Vahedi, ...
Nature structural & molecular biology 21 (12), 1047-1057, 2014
|Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease|
K Hirahara, A Poholek, G Vahedi, A Laurence, Y Kanno, JD Milner, ...
Journal of Allergy and Clinical Immunology 131 (5), 1276-1287, 2013
|TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell-fate decision|
Z Chen, Z Ji, SF Ngiow, S Manne, Z Cai, AC Huang, J Johnson, ...
Immunity 51 (5), 840-855. e5, 2019
|Distinct requirements for T-bet in gut innate lymphoid cells|
G Sciumè, K Hirahara, H Takahashi, A Laurence, AV Villarino, ...
Journal of Experimental Medicine 209 (13), 2331-2338, 2012
|Helper T‐cell differentiation and plasticity: insights from epigenetics|
K Hirahara, G Vahedi, K Ghoreschi, XP Yang, S Nakayamada, Y Kanno, ...
Immunology 134 (3), 235-245, 2011
|Helper T‐cell identity and evolution of differential transcriptomes and epigenomes|
G Vahedi, A C. Poholek, TW Hand, A Laurence, Y Kanno, JJ O'Shea, ...
Immunological reviews 252 (1), 24-40, 2013
|Interleukin-23-induced transcription factor Blimp-1 promotes pathogenicity of T helper 17 cells|
R Jain, Y Chen, Y Kanno, B Joyce-Shaikh, G Vahedi, K Hirahara, ...
Immunity 44 (1), 131-142, 2016
|Asymmetric action of STAT transcription factors drives transcriptional outputs and cytokine specificity|
K Hirahara, A Onodera, AV Villarino, M Bonelli, G Sciumè, A Laurence, ...
Immunity 42 (5), 877-889, 2015
|Lineage-determining transcription factor TCF-1 initiates the epigenetic identity of T cells|
JL Johnson, G Georgakilas, J Petrovic, M Kurachi, S Cai, C Harly, ...
Immunity 48 (2), 243-257. e10, 2018