David Horn
David Horn
Adresse e-mail validée de dundee.ac.uk - Page d'accueil
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The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease
NM El-Sayed, PJ Myler, DC Bartholomeu, D Nilsson, G Aggarwal, ...
Science 309 (5733), 409-415, 2005
The genome of the kinetoplastid parasite, Leishmania major
AC Ivens, CS Peacock, EA Worthey, L Murphy, G Aggarwal, M Berriman, ...
Science 309 (5733), 436-442, 2005
High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome
S Alsford, DJ Turner, SO Obado, A Sanchez-Flores, L Glover, M Berriman, ...
Genome research 21 (6), 915-924, 2011
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes
SR Wilkinson, MC Taylor, D Horn, JM Kelly, I Cheeseman
Proceedings of the National Academy of Sciences 105 (13), 5022-5027, 2008
High-throughput decoding of antitrypanosomal drug efficacy and resistance
S Alsford, S Eckert, N Baker, L Glover, A Sanchez-Flores, KF Leung, ...
Nature 482 (7384), 232-236, 2012
Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
MC Field, D Horn, AH Fairlamb, MAJ Ferguson, DW Gray, KD Read, ...
Nature Reviews Microbiology 15 (4), 217-231, 2017
Antigenic variation in African trypanosomes
D Horn
Molecular and biochemical parasitology 195 (2), 123-129, 2014
Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story
N Baker, HP de Koning, P Mäser, D Horn
Trends in parasitology 29 (3), 110-118, 2013
Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei
BM Mony, P MacGregor, A Ivens, F Rojas, A Cowton, J Young, D Horn, ...
Nature 505 (7485), 681-685, 2014
A doubly inducible system for RNA interference and rapid RNAi plasmid construction in Trypanosoma brucei
VP Alibu, L Storm, S Haile, C Clayton, D Horn
Molecular and biochemical parasitology 139 (1), 75-82, 2005
A developmentally regulated position effect at a telomeric locus in Trypanosoma brucei
D Horn, GAM Cross
Cell 83 (4), 555-561, 1995
Molecular mechanisms underlying the control of antigenic variation in African trypanosomes
D Horn, R McCulloch
Current opinion in microbiology 13 (6), 700-705, 2010
Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes
N Baker, L Glover, JC Munday, DA Andrés, MP Barrett, HP De Koning, ...
Proceedings of the National Academy of Sciences 109 (27), 10996-11001, 2012
Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects
S Alsford, T Kawahara, L Glover, D Horn
Molecular and biochemical parasitology 144 (2), 142-148, 2005
Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei
S Alsford, D Horn
Molecular and biochemical parasitology 161 (1), 76-79, 2008
A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation
S Alsford, T Kawahara, C Isamah, D Horn
Molecular microbiology 63 (3), 724-736, 2007
RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the African trypanosome
SR Wilkinson, D Horn, SR Prathalingam, JM Kelly
Journal of Biological Chemistry 278 (34), 31640-31646, 2003
Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6
N Baker, S Alsford, D Horn
Molecular and biochemical parasitology 176 (1), 55-57, 2011
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of …
JC Munday, AA Eze, N Baker, L Glover, C Clucas, D Aguinaga Andrés, ...
Journal of Antimicrobial Chemotherapy 69 (3), 651-663, 2014
NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions
KN DuBois, S Alsford, JM Holden, J Buisson, M Swiderski, JM Bart, ...
PLoS biology 10 (3), e1001287, 2012
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