Suivre
Jakub Rohlena
Jakub Rohlena
Institute of Biotechnology of the Czech Academy of Sciences
Adresse e-mail validée de ibt.cas.cz
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Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA
AS Tan, JW Baty, LF Dong, A Bezawork-Geleta, B Endaya, J Goodwin, ...
Cell metabolism 21 (1), 81-94, 2015
7082015
Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes
RJ Dekker, JV Van Thienen, J Rohlena, SC De Jager, YW Elderkamp, ...
The American journal of pathology 167 (2), 609-618, 2005
4472005
Classification of mitocans, anti-cancer drugs acting on mitochondria
J Neuzil, LF Dong, J Rohlena, J Truksa, SJ Ralph
Mitochondrion 13 (3), 199-208, 2013
2652013
Mitochondrial complex II: at the crossroads
A Bezawork-Geleta, J Rohlena, L Dong, K Pacak, J Neuzil
Trends in biochemical sciences 42 (4), 312-325, 2017
2612017
Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells
LF Dong, J Kovarova, M Bajzikova, A Bezawork-Geleta, D Svec, ...
elife 6, e22187, 2017
2572017
Key transcriptional regulators of the vasoprotective effects of shear stress
RA Boon, AJG Horrevoets
Hämostaseologie 29 (01), 39-43, 2009
2362009
Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II
LF Dong, VJA Jameson, D Tilly, J Cerny, E Mahdavian, ...
Journal of Biological Chemistry 286 (5), 3717-3728, 2011
2332011
Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells
M Bajzikova, J Kovarova, AR Coelho, S Boukalova, S Oh, K Rohlenova, ...
Cell metabolism 29 (2), 399-416. e10, 2019
2102019
Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2
JO Fledderus, JV Van Thienen, RA Boon, RJ Dekker, J Rohlena, ...
Blood 109 (10), 4249-4257, 2007
1972007
Shear stress sustains atheroprotective endothelial KLF2 expression more potently than statins through mRNA stabilization
JV van Thienen, JO Fledderus, RJ Dekker, J Rohlena, GA van IJzendoorn, ...
Cardiovascular research 72 (2), 231-240, 2006
1812006
Suppression of tumor growth in vivo by the mitocan α-tocopheryl succinate requires respiratory complex II
LF Dong, R Freeman, J Liu, R Zobalova, A Marin-Hernandez, M Stantic, ...
Clinical Cancer Research 15 (5), 1593-1600, 2009
1462009
Mitochondrial complex II, a novel target for anti-cancer agents
K Kluckova, A Bezawork-Geleta, J Rohlena, L Dong, J Neuzil
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1827 (5), 552-564, 2013
1362013
Platelets facilitate the wound-healing capability of mesenchymal stem cells by mitochondrial transfer and metabolic reprogramming
J Levoux, A Prola, P Lafuste, M Gervais, N Chevallier, Z Koumaiha, K Kefi, ...
Cell metabolism 33 (2), 283-299. e9, 2021
1322021
Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: a new paradigm for effective cancer therapy
LF Dong, VJA Jameson, D Tilly, L Prochazka, J Rohlena, K Valis, J Truksa, ...
Free Radical Biology and Medicine 50 (11), 1546-1555, 2011
1242011
Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner
K Valis, L Prochazka, E Boura, J Chladova, T Obsil, J Rohlena, J Truksa, ...
Cancer research 71 (3), 946-954, 2011
1132011
Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2high Breast Cancer
K Rohlenova, K Sachaphibulkij, J Stursa, A Bezawork-Geleta, J Blecha, ...
Antioxidants & redox signaling 26 (2), 84-103, 2017
1112017
Mitochondrial complex II and reactive oxygen species in disease and therapy
K Hadrava Vanova, M Kraus, J Neuzil, J Rohlena
Redox Report 25 (1), 26-32, 2020
1102020
Anticancer drugs targeting the mitochondrial electron transport chain
J Rohlena, LF Dong, SJ Ralph, J Neuzil
Antioxidants & redox signaling 15 (12), 2951-2974, 2011
1072011
Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2
S Hubackova, E Davidova, K Rohlenova, J Stursa, L Werner, L Andera, ...
Cell Death & Differentiation 26 (2), 276-290, 2019
902019
Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer
S Boukalova, S Hubackova, M Milosevic, Z Ezrova, J Neuzil, J Rohlena
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1866 (6), 165759, 2020
872020
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