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K. P. Connie Tam, Ph.D.
K. P. Connie Tam, Ph.D.
Cleveland Clinic Cole Eye Institute and Lerner Research Institute
Verified email at ccf.org
Title
Cited by
Cited by
Year
Cytokeratins mediate epithelial innate defense through their antimicrobial properties
C Tam, JJ Mun, DJ Evans, SMJ Fleiszig
The Journal of clinical investigation 122 (10), 3665-3677, 2012
1552012
Factors impacting corneal epithelial barrier function against Pseudomonas aeruginosa traversal
I Alarcon, C Tam, JJ Mun, J LeDue, DJ Evans, SMJ Fleiszig
Investigative ophthalmology & visual science 52 (3), 1368-1377, 2011
942011
Clearance of Pseudomonas aeruginosa from a Healthy Ocular Surface Involves Surfactant Protein D and Is Compromised by Bacterial Elastase in a Murine Null …
JJ Mun, C Tam, D Kowbel, S Hawgood, MJ Barnett, DJ Evans, ...
Infection and immunity 77 (6), 2392-2398, 2009
872009
Role of Defensins in Corneal Epithelial Barrier Function against Pseudomonas aeruginosa Traversal
DK Augustin, SR Heimer, C Tam, WY Li, JM Le Due, DJ Evans, ...
Infection and immunity 79 (2), 595-605, 2011
822011
The impact of inoculation parameters on the pathogenesis of contact lens–related infectious keratitis
C Tam, JJ Mun, DJ Evans, SMJ Fleiszig
Investigative ophthalmology & visual science 51 (6), 3100-3106, 2010
802010
Association between cytotoxic and invasive Pseudomonas aeruginosa and clinical outcomes in bacterial keratitis
DS Borkar, SMJ Fleiszig, C Leong, P Lalitha, M Srinivasan, AA Ghanekar, ...
JAMA ophthalmology 131 (2), 147-153, 2013
722013
MicroRNA-762 is upregulated in human corneal epithelial cells in response to tear fluid and Pseudomonas aeruginosa antigens and negatively regulates the expression of host …
J Mun, C Tam, G Chan, JH Kim, D Evans, S Fleiszig
PloS one 8 (2), e57850, 2013
522013
Adenylate cyclase activity of Pseudomonas aeruginosa ExoY can mediate bleb-niche formation in epithelial cells and contributes to virulence
V Hritonenko, JJ Mun, C Tam, NC Simon, JT Barbieri, DJ Evans, ...
Microbial pathogenesis 51 (5), 305-312, 2011
462011
Salmonella enterica serovar Dublin strains which are Vi antigen-positive use type IVB pili for bacterial self-association and human intestinal cell entry
C Morris, CKP Tam, TS Wallis, PW Jones, J Hackett
Microbial pathogenesis 35 (6), 279-284, 2003
412003
3D quantitative imaging of unprocessed live tissue reveals epithelial defense against bacterial adhesion and subsequent traversal requires MyD88
C Tam, J LeDue, JJ Mun, P Herzmark, EA Robey, DJ Evans, SMJ Fleiszig
PLoS One 6 (8), e24008, 2011
402011
Mutation of the phospholipase catalytic domain of the Pseudomonas aeruginosa cytotoxin ExoU abolishes colonization promoting activity and reduces corneal disease severity
C Tam, SE Lewis, WY Li, E Lee, DJ Evans, SMJ Fleiszig
Experimental eye research 85 (6), 799-805, 2007
392007
Modulation of epithelial immunity by mucosal fluid
JJ Mun, C Tam, DJ Evans, SMJ Fleiszig
Scientific reports 1 (1), 8, 2011
352011
Expression of surfactant protein D in human corneal epithelial cells is upregulated by Pseudomonas aeruginosa
M Ni, C Tam, A Verma, R Ramphal, S Hawgood, DJ Evans, SMJ Fleiszig
FEMS Immunology & Medical Microbiology 54 (2), 177-184, 2008
302008
Topical tacrolimus nanocapsules eye drops for therapeutic effect enhancement in both anterior and posterior ocular inflammation models
L Rebibo, C Tam, Y Sun, E Shoshani, A Badihi, T Nassar, S Benita
Journal of Controlled Release 333, 283-297, 2021
262021
Traversal of multilayered corneal epithelia by cytotoxic Pseudomonas aeruginosa requires the phospholipase domain of exoU
JC Ramirez, SMJ Fleiszig, AB Sullivan, C Tam, R Borazjani, DJ Evans
Investigative ophthalmology & visual science 53 (1), 448-453, 2012
262012
A novel murine model for contact lens wear reveals clandestine IL-1R dependent corneal parainflammation and susceptibility to microbial keratitis upon inoculation with …
MME Metruccio, SJ Wan, H Horneman, AR Kroken, AB Sullivan, ...
The ocular surface 17 (1), 119-133, 2019
252019
Keratin 6a reorganization for ubiquitin–proteasomal processing is a direct antimicrobial response
JKL Chan, D Yuen, PHM Too, Y Sun, B Willard, D Man, C Tam
Journal of Cell Biology 217 (2), 731-744, 2018
242018
Contributions of MyD88-dependent receptors and CD11c-positive cells to corneal epithelial barrier function against Pseudomonas aeruginosa
MME Metruccio, C Tam, DJ Evans, AL Xie, ME Stern, SMJ Fleiszig
Scientific reports 7 (1), 13829, 2017
232017
Membrane-active epithelial keratin 6A fragments (KAMPs) are unique human antimicrobial peptides with a non-αβ structure
JTY Lee, G Wang, YT Tam, C Tam
Frontiers in microbiology 7, 222508, 2016
202016
Salmonella enterica Serovar Paratyphi C Carries an Inactive Shufflon
CKP Tam, J Hackett, C Morris
Infection and immunity 72 (1), 22-28, 2004
162004
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