| The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases R Chowdhury, KK Yeoh, YM Tian, L Hillringhaus, EA Bagg, NR Rose, ... EMBO reports 12 (5), 463-469, 2011 | 1104 | 2011 |
| Understanding the relationship between DNA methylation and histone lysine methylation NR Rose, RJ Klose Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1839 (12 …, 2014 | 631 | 2014 |
| KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands AM Farcas, NP Blackledge, I Sudbery, HK Long, JF McGouran, NR Rose, ... Elife 1, e00205, 2012 | 488 | 2012 |
| Inhibition of 2-oxoglutarate dependent oxygenases NR Rose, MA McDonough, ONF King, A Kawamura, CJ Schofield Chemical Society Reviews 40 (8), 4364-4397, 2011 | 419 | 2011 |
| Targeting Polycomb systems to regulate gene expression: modifications to a complex story Neil P Blackledge, Nathan R Rose, Robert J Klose Nature Reviews Molecular Cell Biology, 2015 | 372 | 2015 |
| Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity SS Ng, KL Kavanagh, MA McDonough, D Butler, ES Pilka, BMR Lienard, ... Nature 448 (7149), 87-91, 2007 | 347 | 2007 |
| Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases⊥ NR Rose, SS Ng, J Mecinović, BMR Liénard, SH Bello, Z Sun, ... Journal of medicinal chemistry 51 (22), 7053-7056, 2008 | 261 | 2008 |
| Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors ONF King, XS Li, M Sakurai, A Kawamura, NR Rose, SS Ng, AM Quinn, ... PloS one 5 (11), e15535, 2010 | 243 | 2010 |
| Conversion of Cysteine into Dehydroalanine Enables Access to Synthetic Histones Bearing Diverse Post‐Translational Modifications JM Chalker, L Lercher, NR Rose, CJ Schofield, BG Davis Angewandte Chemie International Edition 51 (8), 1835-1839, 2012 | 229 | 2012 |
| PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nε-dimethyl lysine demethylase C Loenarz, W Ge, ML Coleman, NR Rose, CDO Cooper, RJ Klose, ... Human molecular genetics 19 (2), 217-222, 2010 | 183 | 2010 |
| Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family L Hillringhaus, WW Yue, NR Rose, SS Ng, C Gileadi, C Loenarz, SH Bello, ... Journal of Biological Chemistry 286 (48), 41616-41625, 2011 | 179 | 2011 |
| Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches NR Rose, ECY Woon, GL Kingham, ONF King, J Mecinovic, IJ Clifton, ... Journal of medicinal chemistry 53 (4), 1810-1818, 2010 | 179 | 2010 |
| 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ... Chem. Sci., 2013 | 174 | 2013 |
| Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ... Journal of Medicinal Chemistry 55 (14), 6639-6643, 2012 | 158 | 2012 |
| Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases R Chowdhury, JI Candela-Lena, MC Chan, DJ Greenald, KK Yeoh, ... ACS chemical biology, 2013 | 138 | 2013 |
| RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes NR Rose, HW King, NP Blackledge, NA Fursova, KJI Ember, R Fischer, ... eLife 5, e18591, 2016 | 125 | 2016 |
| Inhibition of Histone Demethylases by 4‐Carboxy‐2, 2′‐Bipyridyl Compounds KH Chang, ONF King, A Tumber, ECY Woon, TD Heightman, ... ChemMedChem 6 (5), 759-764, 2011 | 107 | 2011 |
| A miniaturized screen for inhibitors of Jumonji histone demethylases M Sakurai, NR Rose, L Schultz, AM Quinn, A Jadhav, SS Ng, ... Molecular BioSystems 6 (2), 357-364, 2010 | 104 | 2010 |
| Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II) R Sekirnik, NR Rose, A Thalhammer, PT Seden, J Mecinović, ... Chem Commun, 6376-6378, 2009 | 93 | 2009 |
| Linking of 2‐Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases ECY Woon, A Tumber, A Kawamura, L Hillringhaus, W Ge, NR Rose, ... Angewandte Chemie International Edition 51 (7), 1631-1634, 2012 | 83 | 2012 |
Rob KloseProfessor and Chair of Genetics, University of Oxford.Adresse e-mail validée de bioch.ox.ac.uk
