Follow
Alexander Metz
Alexander Metz
Postdoctoral Researcher at Philipps-University Marburg
Verified email at pharmazie.uni-marburg.de - Homepage
Title
Cited by
Cited by
Year
Hot spots and transient pockets: predicting the determinants of small-molecule binding to a protein–protein interface
A Metz, C Pfleger, H Kopitz, S Pfeiffer-Marek, KH Baringhaus, H Gohlke
Journal of chemical information and modeling 52 (1), 120-133, 2012
1422012
Six biophysical screening methods miss a large proportion of crystallographically discovered fragment hits: a case study
J Schiebel, N Radeva, SG Krimmer, X Wang, M Stieler, FR Ehrmann, K Fu, ...
ACS chemical biology 11 (6), 1693-1701, 2016
1122016
One question, multiple answers: biochemical and biophysical screening methods retrieve deviating fragment hit lists
J Schiebel, N Radeva, H Köster, A Metz, T Krotzky, M Kuhnert, ...
ChemMedChem 10 (9), 1511-1521, 2015
712015
Modulating protein-protein interactions: from structural determinants of binding to druggability prediction to application
A Metz, E Ciglia, H Gohlke
Current pharmaceutical design 18 (30), 4630-4647, 2012
672012
Soaking suggests “alternative facts”: Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel …
FR Ehrmann, J Stojko, A Metz, F Debaene, LJ Barandun, A Heine, ...
PLoS One 12 (4), e0175723, 2017
422017
Structures of endothiapepsin–fragment complexes from crystallographic fragment screening using a novel, diverse and affordable 96-compound fragment library
FU Huschmann, J Linnik, K Sparta, M Ühlein, X Wang, A Metz, J Schiebel, ...
Acta Crystallographica Section F: Structural Biology Communications 72 (5 …, 2016
402016
F2X-universal and F2X-entry: structurally diverse compound libraries for crystallographic fragment screening
J Wollenhaupt, A Metz, T Barthel, GMA Lima, A Heine, U Mueller, G Klebe, ...
Structure 28 (6), 694-706. e5, 2020
362020
From determinants of Runx1/Eto tetramerization to small-molecule protein–protein interaction inhibitors targeting acute myeloid leukemia
A Metz, J Schanda, M Grez, C Wichmann, H Gohlke
Journal of chemical information and modeling 53 (9), 2197-2202, 2013
292013
Experimental active-site mapping by fragments: hot spots remote from the catalytic center of endothiapepsin
N Radeva, SG Krimmer, M Stieler, K Fu, X Wang, FR Ehrmann, A Metz, ...
Journal of medicinal chemistry 59 (16), 7561-7575, 2016
212016
Hot‐spot analysis to dissect the functional protein–protein interface of a tRNA‐modifying enzyme
S Jakobi, TXP Nguyen, F Debaene, A Metz, S Sanglier‐Cianférani, ...
Proteins: Structure, Function, and Bioinformatics 82 (10), 2713-2732, 2014
212014
Active site mapping of an aspartic protease by multiple fragment crystal structures: versatile warheads to address a catalytic dyad
N Radeva, J Schiebel, X Wang, SG Krimmer, K Fu, M Stieler, FR Ehrmann, ...
Journal of Medicinal Chemistry 59 (21), 9743-9759, 2016
182016
Suppression of RUNX1/ETO oncogenic activity by a small molecule inhibitor of tetramerization
J Schanda, CW Lee, K Wohlan, U Müller-Kuller, H Kunkel, IQL Coco, ...
Haematologica 102 (5), e170, 2017
142017
Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking
A Metz, J Wollenhaupt, S Glöckner, N Messini, S Huber, T Barthel, ...
Acta Crystallographica Section D: Structural Biology 77 (9), 1168-1182, 2021
102021
Workflow and tools for crystallographic fragment screening at the Helmholtz-Zentrum Berlin
J Wollenhaupt, T Barthel, GMA Lima, A Metz, D Wallacher, E Jagudin, ...
JoVE (Journal of Visualized Experiments), e62208, 2021
102021
Redesigning aldolase stereoselectivity by homologous grafting
C Bisterfeld, T Classen, I Küberl, B Henßen, A Metz, H Gohlke, ...
PLoS One 11 (6), e0156525, 2016
102016
Modular Solid‐Phase Synthesis of Teroxazoles as a Class of α‐Helix Mimetics
C Pinto Gomes, A Metz, JW Bats, H Gohlke, MW Göbel
European Journal of Organic Chemistry 2012 (17), 3270-3277, 2012
102012
Probing ligand binding of endothiapepsin bytemperature-resolved'macromolecular crystallography
CY Huang, S Aumonier, S Engilberge, D Eris, KML Smith, F Leonarski, ...
Acta Crystallographica Section D: Structural Biology 78 (8), 964-974, 2022
82022
Diamondoid Amino Acid‐Based Peptide Kinase A Inhibitor Analogues
J Müller, RA Kirschner, JP Berndt, T Wulsdorf, A Metz, R Hrdina, ...
ChemMedChem 14 (6), 663-672, 2019
72019
Predicting and Exploiting the Determinants of Protein/Protein Interactions to Identify Low-Molecular Inhibitors of Runx1-Eto Tetramerization
A Metz
32014
From C‐H‐Activation to Arene Clusters and Back–Organometallic Cluster Chemistry with Cyclopentadienyl Cobalt Fragments and Olefins
H Wadepohl, A Metz
Metal Clusters in Chemistry, 269-289, 1999
31999
The system can't perform the operation now. Try again later.
Articles 1–20