Suivre
Aaron T. Garrison
Aaron T. Garrison
Senior Scientist, AstraZeneca
Adresse e-mail validée de ufl.edu
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Halogenated Phenazines that Potently Eradicate Biofilms, MRSA Persister Cells in Non‐Biofilm Cultures, and Mycobacterium tuberculosis
AT Garrison, Y Abouelhassan, D Kallifidas, F Bai, M Ukhanova, V Mai, ...
Angewandte Chemie 127 (49), 15032-15036, 2015
922015
Discovery of quinoline small molecules with potent dispersal activity against methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a …
Y Abouelhassan, AT Garrison, GM Burch, W Wong, VM Norwood IV, ...
Bioorganic & Medicinal Chemistry Letters 24 (21), 5076-5080, 2014
862014
Structure–activity relationships of a diverse class of halogenated phenazines that targets persistent, antibiotic-tolerant bacterial biofilms and Mycobacterium tuberculosis
AT Garrison, Y Abouelhassan, VM Norwood IV, D Kallifidas, F Bai, ...
Journal of Medicinal Chemistry 59 (8), 3808-3825, 2016
772016
Recent progress in natural-product-inspired programs aimed to address antibiotic resistance and tolerance
Y Abouelhassan, AT Garrison, H Yang, A Chávez-Riveros, GM Burch, ...
Journal of medicinal chemistry 62 (17), 7618-7642, 2019
742019
An efficient Buchwald–Hartwig/reductive cyclization for the scaffold diversification of halogenated phenazines: potent antibacterial targeting, biofilm eradication, and prodrug …
AT Garrison, Y Abouelhassan, D Kallifidas, H Tan, YS Kim, S Jin, ...
Journal of Medicinal Chemistry 61 (9), 3962-3983, 2018
512018
Bromophenazine derivatives with potent inhibition, dispersion and eradication activities against Staphylococcus aureus biofilms
AT Garrison, F Bai, Y Abouelhassan, NG Paciaroni, S Jin, RW Huigens III
Rsc Advances 5 (2), 1120-1124, 2015
512015
A phytochemical–halogenated quinoline combination therapy strategy for the treatment of pathogenic bacteria
Y Abouelhassan, AT Garrison, F Bai, VM Norwood IV, MT Nguyen, S Jin, ...
ChemMedChem 10 (7), 1157-1162, 2015
362015
Eradicating bacterial biofilms with natural products and their inspired analogues that operate through unique mechanisms
A T Garrison, R W Huigens III
Current topics in medicinal chemistry 17 (17), 1954-1964, 2017
312017
Acute Negative Allosteric Modulation of M5 Muscarinic Acetylcholine Receptors Inhibits Oxycodone Self-Administration and Cue-Induced Reactivity with No Effect …
RW Gould, BW Gunter, M Bubser, RT Matthews, LB Teal, MG Ragland, ...
ACS chemical neuroscience 10 (8), 3740-3750, 2019
292019
Pyrazine and phenazine heterocycles: platforms for total synthesis and drug discovery
RW Huigens III, BR Brummel, S Tenneti, AT Garrison, T Xiao
Molecules 27 (3), 1112, 2022
272022
Microwave-enhanced Friedländer synthesis for the rapid assembly of halogenated quinolines with antibacterial and biofilm eradication activities against drug resistant and …
AT Garrison, Y Abouelhassan, H Yang, HH Yousaf, TJ Nguyen, ...
MedChemComm 8 (4), 720-724, 2017
262017
The Muscarinic Acetylcholine Receptor M5: Therapeutic Implications and Allosteric Modulation
AM Bender, AT Garrison, CW Lindsley
ACS chemical neuroscience 10 (3), 1025-1034, 2018
252018
In vitro antifungal and antibiofilm activities of halogenated quinoline analogues against Candida albicans and Cryptococcus neoformans
R Zuo, AT Garrison, A Basak, P Zhang, RW Huigens III, Y Ding
International journal of antimicrobial agents 48 (2), 208-211, 2016
252016
Recent advances in the synthesis of acridines and phenazines
Y Xiao, W Hu, S Sun, JT Yu, J Cheng
Synlett 30 (19), 2113-2122, 2019
132019
Preparation of 1,5-Dihydropyrazolo[3′,4′:5,6]pyrano[3,4-b]pyridines via a Microwave-Assisted, Palladium-Catalyzed Regioselective C–H Heteroarylation of …
AT Garrison, ES Childress, DC Davis, CW Lindsley
The Journal of Organic Chemistry 84 (9), 5855-5862, 2019
102019
Development of VU6019650: A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M5 Muscarinic Acetylcholine Receptor for the …
AT Garrison, DL Orsi, RA Capstick, D Whomble, J Li, TR Carter, AS Felts, ...
Journal of Medicinal Chemistry 65 (8), 6273-6286, 2022
92022
Palladium-catalyzed oxidative C–H/C–H cross-coupling of pyrazolo [1, 5-a] azines with five-membered heteroarenes
TVQ Nguyen, L Poli, AT Garrison
Chemical Communications 58 (6), 827-830, 2022
62022
Total Synthesis of Hinduchelins A–D, Stereochemical Revision of Hinduchelin A, and Biological Evaluation of Natural and Unnatural Analogues
ES Childress, AT Garrison, JR Sheldon, EP Skaar, CW Lindsley
The Journal of organic chemistry 84 (10), 6459-6464, 2019
62019
Phenazine derivatives as antimicrobial agents
RW Huigens III, A Garrison, Y Abouelhassan, H Yang, G Burch
US Patent 11,053,205, 2021
52021
Abouelhassan Y. Norwood VM Kallifidas D. Bai F. Nguyen MT Rolfe M. Burch GM Jin S. Luesch H. Huigens RW J
AT Garrison
Med. Chem 59, 3808-3825, 2016
52016
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