Siden Top
Siden Top
Directeur de recherche, UPMC
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Synthesis, biochemical properties and molecular modelling studies of organometallic specific estrogen receptor modulators (SERMs), the ferrocifens and hydroxyferrocifens …
S Top, A Vessières, G Leclercq, J Quivy, J Tang, J Vaissermann, M Huché, ...
Chemistry–A European Journal 9 (21), 5223-5236, 2003
Ferrocifen type anti cancer drugs
G Jaouen, A Vessières, S Top
Chemical Society Reviews 44 (24), 8802-8817, 2015
The first organometallic selective estrogen receptor modulators (SERMs) and their relevance to breast cancer
G Jaouen, S Top, A Vessieres, G Leclercq, MJ McGlinchey
Current medicinal chemistry 11 (18), 2505-2517, 2004
Studies on organometallic selective estrogen receptor modulators.(SERMs) Dual activity in the hydroxy-ferrocifen series
S Top, A Vessieres, C Cabestaing, I Laios, G Leclercq, C Provot, ...
Journal of Organometallic Chemistry 637, 500-506, 2001
Modification of the estrogenic properties of diphenols by the incorporation of ferrocene. Generation of antiproliferative effects in vitro
A Vessieres, S Top, P Pigeon, E Hillard, L Boubeker, D Spera, G Jaouen
Journal of medicinal chemistry 48 (12), 3937-3940, 2005
Rhenium Carbonyl Complexes of. beta.-Estradiol Derivatives with High Affinity for the Estradiol Receptor: An Approach to Selective Organometallic Radiopharmaceuticals
S Top, H El Hafa, A Vessieres, J Quivy, J Vaissermann, DW Hughes, ...
Journal of the American Chemical Society 117 (32), 8372-8380, 1995
Ferrocenyl hydroxytamoxifen: a prototype for a new range of oestradiol receptor site-directed cytotoxics
S Top, J Tang, A Vessières, D Carrez, C Provot, G Jaouen
Chemical Communications, 955-956, 1996
Facile route to ferrocifen, 1-[4-(2-dimethylaminoethoxy)]-1-(phenyl-2-ferrocenyl-but-1-ene), first organometallic analogue of tamoxifen, by the McMurry reaction
S Top, B Dauer, J Vaissermann, G Jaouen
Journal of Organometallic Chemistry 541 (1-2), 355-361, 1997
Ferrocifens and ferrocifenols as new potential weapons against breast cancer
A Nguyen, A Vessières, EA Hillard, S Top, P Pigeon, G Jaouen
CHIMIA International Journal for Chemistry 61 (11), 716-724, 2007
Ferrocenyl quinone methides as strong antiproliferative agents: formation by metabolic and chemical oxidation of ferrocenyl phenols
D Hamels, PM Dansette, EA Hillard, S Top, A Vessières, P Herson, ...
Angewandte Chemie 121 (48), 9288-9290, 2009
New paradigms for synthetic pathways inspired by bioorganometallic chemistry
G Jaouen, S Top, A Vessières, R Alberto
Journal of Organometallic Chemistry 600 (1-2), 23-36, 2000
Metal complex SERMs (selective oestrogen receptor modulators). The influence of different metal units on breast cancer cell antiproliferative effects
A Vessières, S Top, W Beck, E Hillard, G Jaouen
Dalton Transactions, 529-541, 2006
N-Alkylation of nitriles using chromium tricarbonyl complexes of benzyl alcohol and its derivatives: New perspectives for the Ritter reaction
S Top, G Jaouen
The Journal of Organic Chemistry 46 (1), 78-82, 1981
Organometallic estrogens: Synthesis, interaction with lamb uterine estrogen receptor, and detection by infrared spectroscopy
A Vessieres, S Top, AA Ismail, IS Butler, M Louer, G Jaouen
Biochemistry 27 (18), 6659-6666, 1988
Labeling of proteins by organometallic complexes of rhenium (I). Synthesis and biological activity of the conjugates
M Salmain, M Gunn, A Gorfti, S Top, G Jaouen
Bioconjugate chemistry 4 (6), 425-433, 1993
Selective estrogen receptor modulators in the ruthenocene series. Synthesis and biological behavior
P Pigeon, S Top, A Vessières, M Huché, EA Hillard, E Salomon, G Jaouen
Journal of medicinal chemistry 48 (8), 2814-2821, 2005
Metal carbonyl fragments as a new class of markers in molecular biology
G Jaouen, A Vessieres, S Top, AA Ismail, IS Butler
Journal of the American Chemical Society 107 (16), 4778-4780, 1985
Synthesis and structure–activity relationships of the first ferrocenyl-aryl-hydantoin derivatives of the nonsteroidal antiandrogen nilutamide
O Payen, S Top, A Vessières, E Brulé, MA Plamont, M J. McGlinchey, ...
Journal of medicinal chemistry 51 (6), 1791-1799, 2008
Chromium tricarbonyl complexes of estradiol derivatives: differentiation of. alpha.-and. beta.-diastereoisomers using 1-and 2-dimensional NMR spectroscopy at 500 MHz
S Top, G Jaouen, A Vessieres, JP Abjean, D Davoust, CA Rodger, ...
Organometallics 4 (12), 2143-2150, 1985
Evidence for targeting thioredoxin reductases with ferrocenyl quinone methides. A possible molecular basis for the antiproliferative effect of hydroxyferrocifens on cancer cells
A Citta, A Folda, A Bindoli, P Pigeon, S Top, A Vessieres, M Salmain, ...
Journal of Medicinal Chemistry 57 (21), 8849-8859, 2014
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