Douglas Brash
Douglas Brash
Professor of Therapeutic Radiology, Genetics, and Dermatology
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Cited by
Cited by
A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.
DE Brash, JA Rudolph, JA Simon, A Lin, GJ McKenna, HP Baden, ...
Proceedings of the National Academy of Sciences 88 (22), 10124-10128, 1991
Sunburn and p53 in the onset of skin cancer
A Ziegler, AS Jonason, DJ Leffellt, JA Simon, HW Sharma, J Kimmelman, ...
Nature 372 (6508), 773-776, 1994
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
M Krauthammer, Y Kong, BH Ha, P Evans, A Bacchiocchi, JP McCusker, ...
Nature genetics 44 (9), 1006-1014, 2012
The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas
MR Gailani, M Ståhle-Bäckdahl, DJ Leffell, M Glyn, PG Zaphiropoulos, ...
Nature genetics 14 (1), 78-81, 1996
Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a …
RR Reddel, Y Ke, BI Gerwin, MG McMenamin, JF Lechner, RT Su, ...
Cancer research 48 (7), 1904-1909, 1988
Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers
A Ziegler, DJ Leffell, S Kunala, HW Sharma, M Gailani, JA Simon, ...
Proceedings of the National Academy of Sciences 90 (9), 4216, 1993
Frequent clones of p53-mutated keratinocytes in normal human skin
AS Jonason, S Kunala, GJ Price, RJ Restifo, HM Spinelli, JA Persing, ...
Proceedings of the National Academy of Sciences 93 (24), 14025-14029, 1996
Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion.
DE Brash, A Ziegler, AS Jonason, JA Simon, S Kunala, DJ Leffell
The journal of investigative dermatology. Symposium proceedings 1 (2), 136-142, 1996
Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure
S Premi, S Wallisch, CM Mano, AB Weiner, A Bacchiocchi, K Wakamatsu, ...
Science 347 (6224), 842-847, 2015
UV-induced mutation hotspots occur at DNA damage hotspots
DE Brash, WA Haseltine
Nature 298 (5870), 189-192, 1982
UV signature mutations
DE Brash
Photochemistry and photobiology 91 (1), 15-26, 2015
Sunlight and the onset of skin cancer
DE Brash
Trends in genetics 13 (10), 410-414, 1997
Distribution of UV light-induced damage in a defined sequence of human DNA: detection of alkaline-sensitive lesions at pyrimidine nucleoside-cytidine sequences.
JA Lippke, LK Gordon, DE Brash, WA Haseltine
Proceedings of the National Academy of Sciences 78 (6), 3388-3392, 1981
Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53
D Grossman, PJ Kim, OP Blanc-Brude, DE Brash, S Tognin, PC Marchisio, ...
The Journal of clinical investigation 108 (7), 991-999, 2001
UV mutagenic photoproducts in Escherichia coli and human cells: a molecular genetics perspective on human skin cancer
DE Brash
Photochemistry and photobiology 48 (1), 59-66, 1988
Common contaminants in next-generation sequencing that hinder discovery of low-abundance microbes
M Laurence, C Hatzis, DE Brash
PloS one 9 (5), e97876, 2014
Keratinocyte apoptosis in epidermal development and disease
D Raj, DE Brash, D Grossman
Journal of Investigative Dermatology 126 (2), 243-257, 2006
Photoproduct frequency is not the major determinant of UV base substitution hot spots or cold spots in human cells.
DE Brash, S Seetharam, KH Kraemer, MM Seidman, A Bredberg
Proceedings of the National Academy of Sciences 84 (11), 3782-3786, 1987
Ultraviolet radiation induced signature mutations in photocarcinogenesis
NM Wikonkal, DE Brash
Journal of Investigative Dermatology Symposium Proceedings 4 (1), 6-10, 1999
Relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma
MR Gailani, DJ Leffell, AM Ziegler, EG Gross, DE Brash, AE Bale
JNCI: Journal of the National Cancer Institute 88 (6), 349-354, 1996
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