Douglas M Fowler
Douglas M Fowler
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Functional amyloid–from bacteria to humans
DM Fowler, AV Koulov, WE Balch, JW Kelly
Trends in biochemical sciences 32 (5), 217-224, 2007
Functional amyloid formation within mammalian tissue
DM Fowler, AV Koulov, C Alory-Jost, MS Marks, WE Balch, JW Kelly
PLoS biology 4 (1), e6, 2006
Deep mutational scanning: a new style of protein science
DM Fowler, S Fields
Nature methods 11 (8), 801-807, 2014
Semen-derived amyloid fibrils drastically enhance HIV infection
J Münch, E Rücker, L Ständker, K Adermann, C Goffinet, M Schindler, ...
Cell 131 (6), 1059-1071, 2007
High-resolution mapping of protein sequence-function relationships
DM Fowler, CL Araya, SJ Fleishman, EH Kellogg, JJ Stephany, D Baker, ...
Nature methods 7 (9), 741-746, 2010
Structure of the Sec13/31 COPII coat cage
SM Stagg, C Gürkan, DM Fowler, P LaPointe, TR Foss, CS Potter, ...
Nature 439 (7073), 234-238, 2006
Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate α-synuclein fibrilization
DA Bosco, DM Fowler, Q Zhang, J Nieva, ET Powers, P Wentworth, ...
Nature chemical biology 2 (5), 249-253, 2006
Massively parallel functional analysis of BRCA1 RING domain variants
LM Starita, DL Young, M Islam, JO Kitzman, J Gullingsrud, RJ Hause, ...
Genetics 200 (2), 413-422, 2015
Variant interpretation: functional assays to the rescue
LM Starita, N Ahituv, MJ Dunham, JO Kitzman, FP Roth, G Seelig, ...
The American Journal of Human Genetics 101 (3), 315-325, 2017
A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function
CL Araya, DM Fowler, W Chen, I Muniez, JW Kelly, S Fields
Proceedings of the National Academy of Sciences 109 (42), 16858-16863, 2012
The dynamin middle domain is critical for tetramerization and higher‐order self‐assembly
R Ramachandran, M Surka, JS Chappie, DM Fowler, TR Foss, BD Song, ...
The EMBO journal 26 (2), 559-566, 2007
Multiplex assessment of protein variant abundance by massively parallel sequencing
KA Matreyek, LM Starita, JJ Stephany, B Martin, MA Chiasson, VE Gray, ...
Nature genetics 50 (6), 874-882, 2018
Deep mutational scanning: assessing protein function on a massive scale
CL Araya, DM Fowler
Trends in biotechnology 29 (9), 435-442, 2011
Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis
LM Starita, JN Pruneda, RS Lo, DM Fowler, HJ Kim, JB Hiatt, J Shendure, ...
Proceedings of the National Academy of Sciences 110 (14), E1263-E1272, 2013
Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis
TW Mu, DM Fowler, JW Kelly
PLoS biology 6 (2), e26, 2008
Measuring the activity of protein variants on a large scale using deep mutational scanning
DM Fowler, JJ Stephany, S Fields
Nature protocols 9 (9), 2267-2284, 2014
Enrich: software for analysis of protein function by enrichment and depletion of variants
DM Fowler, CL Araya, W Gerard, S Fields
Bioinformatics 27 (24), 3430-3431, 2011
Pharmacogenomics of CYP2C9: functional and clinical considerations
AK Daly, AE Rettie, DM Fowler, JO Miners
Journal of personalized medicine 8 (1), 1, 2018
Quantitative missense variant effect prediction using large-scale mutagenesis data
VE Gray, RJ Hause, J Luebeck, J Shendure, DM Fowler
Cell systems 6 (1), 116-124. e3, 2018
N-terminal domains elicit formation of functional Pmel17 amyloid fibrils
B Watt, G van Niel, DM Fowler, I Hurbain, KC Luk, SE Stayrook, ...
Journal of Biological Chemistry 284 (51), 35543-35555, 2009
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