John Blenis
John Blenis
Professor of Pharmacology, Weill Cornell Medicine
Adresse e-mail validée de med.cornell.edu - Page d'accueil
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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
A Brunet, A Bonni, MJ Zigmond, MZ Lin, P Juo, LS Hu, MJ Anderson, ...
cell 96 (6), 857-868, 1999
71451999
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions
PP Roux, J Blenis
Microbiology and molecular biology reviews 68 (2), 320-344, 2004
27732004
Molecular mechanisms of mTOR-mediated translational control
XM Ma, J Blenis
Nature reviews Molecular cell biology 10 (5), 307-318, 2009
24102009
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
BD Manning, AR Tee, MN Logsdon, J Blenis, LC Cantley
Molecular cell 10 (1), 151-162, 2002
16802002
Signal transduction via the MAP kinases: proceed at your own RSK
J Blenis
Proceedings of the National Academy of Sciences 90 (13), 5889-5892, 1993
15911993
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
DC Fingar, J Blenis
Oncogene 23 (18), 3151-3171, 2004
14802004
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
MC Mendoza, EE Er, J Blenis
Trends in biochemical sciences 36 (6), 320-328, 2011
14662011
Nuclear localization and regulation of erk-and rsk-encoded protein kinases.
RH Chen, C Sarnecki, J Blenis
Molecular and cellular biology 12 (3), 915-927, 1992
13521992
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.
B Cheatham, CJ Vlahos, L Cheatham, L Wang, J Blenis, CR Kahn
Molecular and cellular biology 14 (7), 4902-4911, 1994
13461994
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
J Chung, CJ Kuo, GR Crabtree, J Blenis
Cell 69 (7), 1227-1236, 1992
12851992
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
AR Tee, BD Manning, PP Roux, LC Cantley, J Blenis
Current biology 13 (15), 1259-1268, 2003
12742003
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
DC Fingar, S Salama, C Tsou, ED Harlow, J Blenis
Genes & development 16 (12), 1472-1487, 2002
11792002
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
MK Holz, BA Ballif, SP Gygi, J Blenis
Cell 123 (4), 569-580, 2005
11372005
Molecular interpretation of ERK signal duration by immediate early gene products
LO Murphy, S Smith, RH Chen, DC Fingar, J Blenis
Nature cell biology 4 (8), 556-564, 2002
10622002
ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK
KW Wood, C Sarnecki, TM Roberts, J Blenis
Cell 68 (6), 1041-1050, 1992
10401992
FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
MR Sprick, MA Weigand, E Rieser, CT Rauch, P Juo, J Blenis, ...
Immunity 12 (6), 599-609, 2000
9542000
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
DC Fingar, CJ Richardson, AR Tee, L Cheatham, C Tsou, J Blenis
Molecular and cellular biology 24 (1), 200-216, 2004
9482004
Tuberous sclerosis complex-1 and-2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
AR Tee, DC Fingar, BD Manning, DJ Kwiatkowski, LC Cantley, J Blenis
Proceedings of the National Academy of Sciences 99 (21), 13571-13576, 2002
8992002
Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated …
S Agrawal, A Agrawal, B Doughty, A Gerwitz, J Blenis, T Van Dyke, ...
The Journal of Immunology 171 (10), 4984-4989, 2003
8962003
PDGF-and insulin-dependent pp70 S6k activation mediated by phosphatidylinositol-3-OH kinase
J Chung, TC Grammar, KP Lemon, A Kazlauskas, J Blenis
Nature 370 (6484), 71-75, 1994
8631994
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