Ji Luo
Ji Luo
National Cancer Institute
Adresse e-mail validée de nih.gov
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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
JA Engelman, J Luo, LC Cantley
Nature Reviews Genetics 7 (8), 606-619, 2006
Principles of cancer therapy: oncogene and non-oncogene addiction
J Luo, NL Solimini, SJ Elledge
Cell 136 (5), 823-837, 2009
Targeting the PI3K-Akt pathway in human cancer: rationale and promise
J Luo, BD Manning, LC Cantley
Cancer cell 4 (4), 257-262, 2003
Drugging the undruggable RAS: mission possible?
AD Cox, SW Fesik, AC Kimmelman, J Luo, CJ Der
Nature reviews Drug discovery 13 (11), 828-851, 2014
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene
J Luo, MJ Emanuele, D Li, CJ Creighton, MR Schlabach, TF Westbrook, ...
Cell 137 (5), 835-848, 2009
Breast cancer–associated PIK3CA mutations are oncogenic in mammary epithelial cells
SJ Isakoff, JA Engelman, HY Irie, J Luo, SM Brachmann, RV Pearline, ...
Cancer research 65 (23), 10992-11000, 2005
Cancer proliferation gene discovery through functional genomics
MR Schlabach, J Luo, NL Solimini, G Hu, Q Xu, MZ Li, Z Zhao, ...
Science 319 (5863), 620-624, 2008
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
JW Hill, KW Williams, C Ye, J Luo, N Balthasar, R Coppari, MA Cowley, ...
The Journal of clinical investigation 118 (5), 1796-1805, 2008
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKCλ/ζ
CM Taniguchi, T Kondo, M Sajan, J Luo, R Bronson, T Asano, R Farese, ...
Cell metabolism 3 (5), 343-353, 2006
Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy
J Luo, JR McMullen, CL Sobkiw, L Zhang, AL Dorfman, MC Sherwood, ...
Molecular and cellular biology 25 (21), 9491-9502, 2005
The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
J Luo, SJ Field, JY Lee, JA Engelman, LC Cantley
The Journal of cell biology 170 (3), 455-464, 2005
Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTEN
CM Taniguchi, TT Tran, T Kondo, J Luo, K Ueki, LC Cantley, CR Kahn
Proceedings of the National Academy of Sciences 103 (32), 12093-12097, 2006
Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia
J Luo, CL Sobkiw, MF Hirshman, MN Logsdon, TQ Li, LJ Goodyear, ...
Cell metabolism 3 (5), 355-366, 2006
Deletion of the phosphoinositide 3-kinase p110γ gene attenuates murine atherosclerosis
JD Chang, GK Sukhova, P Libby, E Schvartz, AH Lichtenstein, SJ Field, ...
Proceedings of the National Academy of Sciences 104 (19), 8077-8082, 2007
Then negative regulation of phosphoinositide 3-kinase signaling by p85 and its implication in cancer
J Luo, LC Cantley
Cell cycle 4 (10), 1309-1312, 2005
Class 1A PI3K regulates vessel integrity during development and tumorigenesis
TL Yuan, HS Choi, A Matsui, C Benes, E Lifshits, J Luo, JV Frangioni, ...
Proceedings of the National Academy of Sciences 105 (28), 9739-9744, 2008
The p85α regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance
CM Taniguchi, JO Aleman, K Ueki, J Luo, T Asano, H Kaneto, ...
Molecular and cellular biology 27 (8), 2830-2840, 2007
Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis
JW Hill, Y Xu, F Preitner, M Fukuda, YR Cho, J Luo, N Balthasar, ...
Endocrinology 150 (11), 4874-4882, 2009
Development of siRNA payloads to target KRAS-mutant cancer
TL Yuan, C Fellmann, CS Lee, CD Ritchie, V Thapar, LC Lee, DJ Hsu, ...
Cancer discovery 4 (10), 1182-1197, 2014
Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase
JS Oak, JA Deane, MG Kharas, J Luo, TE Lane, LC Cantley, DA Fruman
Proceedings of the National Academy of Sciences 103 (45), 16882-16887, 2006
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