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Jeffrey Umotoy
Jeffrey Umotoy
University of Amsterdam
Adresse e-mail validée de amsterdamumc.nl
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A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses
JM Steichen, YC Lin, C Havenar-Daughton, S Pecetta, G Ozorowski, ...
Science 366 (6470), eaax4380, 2019
1762019
HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage
E Landais, B Murrell, B Briney, S Murrell, K Rantalainen, ZT Berndsen, ...
Immunity 47 (5), 990-1003. e9, 2017
952017
Rapid and focused maturation of a VRC01-class HIV broadly neutralizing antibody lineage involves both binding and accommodation of the N276-glycan
J Umotoy, BS Bagaya, C Joyce, T Schiffner, S Menis, KL Saye-Francisco, ...
Immunity 51 (1), 141-154. e6, 2019
672019
Co-evolution of HIV envelope and apex-targeting neutralizing antibody lineage provides benchmarks for vaccine design
K Rantalainen, ZT Berndsen, S Murrell, L Cao, O Omorodion, JL Torres, ...
Cell reports 23 (11), 3249-3261, 2018
512018
Nitrosopurines en route to potently cytotoxic asmarines
KK Wan, K Iwasaki, JC Umotoy, DW Wolan, RA Shenvi
Angewandte Chemie 127 (8), 2440-2445, 2015
372015
Synthesis and Sulfur Electrophilicity of the Nuphar Thiaspirane Pharmacophore
N Tada, DJ Jansen, MP Mower, MM Blewett, JC Umotoy, BF Cravatt, ...
ACS central science 2 (6), 401-408, 2016
252016
Selective inhibition of initiator versus executioner caspases using small peptides containing unnatural amino acids
CJ Vickers, GE González-Páez, KM Litwin, JC Umotoy, EA Coutsias, ...
ACS Chemical Biology 9 (10), 2194-2198, 2014
212014
Lassa virus glycoprotein nanoparticles elicit neutralizing antibody responses and protection
PJM Brouwer, A Antanasijevic, AJ Ronk, H Müller-Kräuter, Y Watanabe, ...
Cell Host & Microbe 30 (12), 1759-1772. e12, 2022
202022
Small‐Molecule Procaspase Activators Identified Using Fluorescence Polarization
CJ Vickers, GE González‐Páez, JC Umotoy, C Cayanan‐Garrett, ...
ChemBioChem 14 (12), 1419-1422, 2013
192013
Antibody conjugates for targeted therapy against HIV-1 as an emerging tool for HIV-1 cure
JC Umotoy, SW De Taeye
Frontiers in immunology 12, 708806, 2021
152021
A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses. Science 366: eaax4380
JM Steichen, YC Lin, C Havenar-Daughton, S Pecetta, G Ozorowski, ...
102019
Co-evolution of HIV envelope and apex-targeting neutralizing antibody lineage provides benchmarks for vaccine design. Cell Rep 23: 3249–3261
K Rantalainen, ZT Berndsen, S Murrell, L Cao, O Omorodion, JL Torres, ...
62018
Evolution of a Chemical Strategy Toward the Synthesis of Unsymmetrically Oxidized Nuphar Alkaloids
JJ Lacharity, A Zakarian
Synlett 30 (14), 1632-1642, 2019
12019
Complementary antibody lineages achieve neutralization breadth in an HIV-1 infected elite neutralizer
J van Schooten, A Schorcht, E Farokhi, JC Umotoy, H Gao, ...
PLoS pathogens 18 (11), e1010945, 2022
2022
PP 8.8–00129 Antibody mediated killing of HIV-1 infected cells with glycoengineered broadly neutralizing antibodies
S De Taeye, A Schriek, J Umotoy, M Grobben, D Falck, R Sanders, ...
2022
Engineering better bnAbs
PN Kelly
Science 366 (6470), 1209-1211, 2019
2019
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