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Gabriel Rocklin
Gabriel Rocklin
Assistant Professor, Northwestern University, Dept. of Pharmacology and Center for Synthetic Biology
Adresse e-mail validée de northwestern.edu - Page d'accueil
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Global analysis of protein folding using massively parallel design, synthesis, and testing
GJ Rocklin, TM Chidyausiku, I Goreshnik, A Ford, S Houliston, A Lemak, ...
Science 357 (6347), 168-175, 2017
4812017
Massively parallel de novo protein design for targeted therapeutics
A Chevalier, DA Silva, GJ Rocklin, DR Hicks, R Vergara, P Murapa, ...
Nature 550 (7674), 74-79, 2017
4142017
Accurate de novo design of hyperstable constrained peptides
G Bhardwaj, VK Mulligan, CD Bahl, JM Gilmore, PJ Harvey, O Cheneval, ...
Nature 538 (7625), 329, 2016
3802016
Calculating the binding free energies of charged species based on explicit-solvent simulations employing lattice-sum methods: An accurate correction scheme for electrostatic …
GJ Rocklin, DL Mobley, KA Dill, PH Hünenberger
The Journal of chemical physics 139 (18), 2013
2302013
Predicting ligand binding affinity with alchemical free energy methods in a polar model binding site
SE Boyce, DL Mobley, GJ Rocklin, AP Graves, KA Dill, BK Shoichet
Journal of molecular biology 394 (4), 747-763, 2009
2112009
Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling
C DerMardirossian, G Rocklin, JY Seo, GM Bokoch
Molecular biology of the cell 17 (11), 4760-4768, 2006
2012006
Docking for fragment inhibitors of AmpC β-lactamase
DG Teotico, K Babaoglu, GJ Rocklin, RS Ferreira, AM Giannetti, ...
Proceedings of the National Academy of Sciences 106 (18), 7455-7460, 2009
1322009
Mega-scale experimental analysis of protein folding stability in biology and design
K Tsuboyama, J Dauparas, J Chen, E Laine, Y Mohseni Behbahani, ...
Nature 620, 434-444, 2023
642023
Blind prediction of charged ligand binding affinities in a model binding site
GJ Rocklin, SE Boyce, M Fischer, I Fish, DL Mobley, BK Shoichet, KA Dill
Journal of molecular biology 425 (22), 4569-4583, 2013
612013
Computational design of a synthetic PD-1 agonist
CM Bryan, GJ Rocklin, MJ Bick, A Ford, S Majri-Morrison, AV Kroll, ...
Proceedings of the National Academy of Sciences 118 (29), e2102164118, 2021
372021
Calculating the sensitivity and robustness of binding free energy calculations to force field parameters
GJ Rocklin, DL Mobley, KA Dill
Journal of chemical theory and computation 9 (7), 3072-3083, 2013
352013
Separated topologies—A method for relative binding free energy calculations using orientational restraints
GJ Rocklin, DL Mobley, KA Dill
The Journal of chemical physics 138 (8), 2013
342013
Large-scale design and refinement of stable proteins using sequence-only models
JM Singer, S Novotney, D Strickland, HK Haddox, N Leiby, GJ Rocklin, ...
PloS one 17 (3), e0265020, 2022
232022
The influence of proline isomerization on potency and stability of anti-HIV antibody 10E8
M Guttman, NN Padte, Y Huang, J Yu, GJ Rocklin, BD Weitzner, M Scian, ...
Scientific reports 10 (1), 14313, 2020
142020
Prediction and validation of a protein’s free energy surface using hydrogen exchange and (importantly) its denaturant dependence
X Peng, M Baxa, N Faruk, JR Sachleben, S Pintscher, IA Gagnon, ...
Journal of chemical theory and computation 18 (1), 550-561, 2021
82021
Dissecting the stability determinants of a challenging de novo protein fold using massively parallel design and experimentation
TE Kim, K Tsuboyama, S Houliston, CM Martell, CM Phoumyvong, ...
Proceedings of the National Academy of Sciences 119 (41), e2122676119, 2022
42022
In vivo selection of synthetic nucleocapsids for tissue targeting
A Olshefsky, H Benasutti, M Sylvestre, GL Butterfield, GJ Rocklin, ...
Proceedings of the National Academy of Sciences 120 (46), e2306129120, 2023
2023
Protein folding stability measured at scale
GJ Rocklin, K Tsuboyama
2023
FOLDED AND PROTEASE-RESISTANT POLYPEPTIDES
GJ Rocklin, D Baker
US Patent App. 16/489,044, 2021
2021
De novo designed hemagglutinin binding proteins
D Baker, AA Chevalier, GJ Rocklin, CD Bahl, LJ Stewart, DAS MANZANO, ...
US Patent 10,766,929, 2020
2020
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