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Gregory L. Dignon
Gregory L. Dignon
Assistant Professor of Chemical Engineering - Rutgers University
Adresse e-mail validée de rutgers.edu - Page d'accueil
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Phosphorylation of the FUS low‐complexity domain disrupts phase separation, aggregation, and toxicity
Z Monahan, VH Ryan, AM Janke, KA Burke, SN Rhoads, GH Zerze, ...
The EMBO journal 36 (20), 2951-2967, 2017
5842017
Molecular interactions underlying liquid− liquid phase separation of the FUS low-complexity domain
AC Murthy, GL Dignon, Y Kan, GH Zerze, SH Parekh, J Mittal, NL Fawzi
Nature structural & molecular biology 26 (7), 637-648, 2019
4832019
Sequence determinants of protein phase behavior from a coarse-grained model
GL Dignon, W Zheng, YC Kim, RB Best, J Mittal
PLoS computational biology 14 (1), e1005941, 2018
4162018
Biomolecular phase separation: from molecular driving forces to macroscopic properties
GL Dignon, RB Best, J Mittal
Annual review of physical chemistry 71, 53-75, 2020
3792020
Mechanistic view of hnRNPA2 low-complexity domain structure, interactions, and phase separation altered by mutation and arginine methylation
VH Ryan, GL Dignon, GH Zerze, CV Chabata, R Silva, AE Conicella, ...
Molecular cell 69 (3), 465-479. e7, 2018
3382018
Relation between single-molecule properties and phase behavior of intrinsically disordered proteins
GL Dignon, W Zheng, RB Best, YC Kim, J Mittal
Proceedings of the National Academy of Sciences 115 (40), 9929-9934, 2018
2712018
TDP-43 α-helical structure tunes liquid–liquid phase separation and function
AE Conicella, GL Dignon, GH Zerze, HB Schmidt, AM D’Ordine, YC Kim, ...
Proceedings of the National Academy of Sciences 117 (11), 5883-5894, 2020
2682020
Temperature-controlled liquid–liquid phase separation of disordered proteins
GL Dignon, W Zheng, YC Kim, J Mittal
ACS central science 5 (5), 821-830, 2019
2072019
Identifying sequence perturbations to an intrinsically disordered protein that determine its phase-separation behavior
BS Schuster, GL Dignon, WS Tang, FM Kelley, AK Ranganath, ...
Proceedings of the National Academy of Sciences 117 (21), 11421-11431, 2020
1972020
Molecular details of protein condensates probed by microsecond long atomistic simulations
W Zheng, GL Dignon, N Jovic, X Xu, RM Regy, NL Fawzi, YC Kim, ...
The Journal of Physical Chemistry B 124 (51), 11671-11679, 2020
1212020
Simulation methods for liquid–liquid phase separation of disordered proteins
GL Dignon, W Zheng, J Mittal
Current opinion in chemical engineering 23, 92-98, 2019
952019
Sequence dependent phase separation of protein-polynucleotide mixtures elucidated using molecular simulations
RM Regy, GL Dignon, W Zheng, YC Kim, J Mittal
Nucleic acids research 48 (22), 12593-12603, 2020
722020
Hydropathy patterning complements charge patterning to describe conformational preferences of disordered proteins
W Zheng, G Dignon, M Brown, YC Kim, J Mittal
The journal of physical chemistry letters 11 (9), 3408-3415, 2020
692020
The protein folding problem: The role of theory
R Nassar, GL Dignon, RM Razban, KA Dill
Journal of molecular biology 433 (20), 167126, 2021
632021
A predictive coarse-grained model for position-specific effects of post-translational modifications
TM Perdikari, N Jovic, GL Dignon, YC Kim, NL Fawzi, J Mittal
Biophysical Journal 120 (7), 1187-1197, 2021
552021
Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration
VH Ryan, TM Perdikari, MT Naik, CF Saueressig, J Lins, GL Dignon, ...
The EMBO Journal 40 (3), e105001, 2021
472021
Interplay between membrane composition and structural stability of membrane-bound hIAPP
GL Dignon, GH Zerze, J Mittal
The Journal of Physical Chemistry B 121 (37), 8661-8668, 2017
282017
Accelerating Protein Folding Molecular Dynamics Using Inter-Residue Distances from Machine Learning Servers
R Nassar, E Brini, S Parui, C Liu, GL Dignon, KA Dill
Journal of Chemical Theory and Computation 18 (3), 1929-1935, 2022
102022
A High-Throughput Approach to Phase Separation of Disordered Proteins
GL Dignon, W Zheng, Y Kim, J Mittal
Biophysical Journal 116 (3), 350a, 2019
22019
Alpha-Helical Structure in TDP-43 Tunes Liquid-liquid Phase Separation and Cellular Function
AE Conicella, G Dignon, GH Zerze, B Schmidt, MD Alexandra, Y Kim, ...
Biophysical Journal 118 (3), 5a-6a, 2020
12020
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