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Mitko Dimitrov
Mitko Dimitrov
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Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repellent deet
V Corbel, M Stankiewicz, C Pennetier, D Fournier, J Stojan, E Girard, ...
BMC biology 7 (1), 47, 2009
2502009
Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production
M Dimitrov, JR Alattia, T Lemmin, R Lehal, A Fligier, J Houacine, ...
Nature Communications 4, 2013
1092013
Calcium-sensing receptor attenuates AVP-induced aquaporin-2 expression via a calmodulin-dependent mechanism
M Bustamante, U Hasler, V Leroy, S de Seigneux, M Dimitrov, ...
Journal of the American Society of Nephrology 19 (1), 109-116, 2008
1052008
NF-κB modulates aquaporin-2 transcription in renal collecting duct principal cells
U Hasler, V Leroy, US Jeon, R Bouley, M Dimitrov, JA Kim, D Brown, ...
Journal of Biological Chemistry 283 (42), 28095-28105, 2008
862008
Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production
H Gerber, F Wu, M Dimitrov, GMG Osuna, PC Fraering
Journal of Biological Chemistry, jbc. M116. 754101, 2017
742017
Label-free imaging of cerebral β-Amyloidosis with extended-focus optical coherence microscopy
T Bolmont, A Bouwens, C Pache, M Dimitrov, C Berclaz, M Villiger, ...
The Journal of Neuroscience 32 (42), 14548-14556, 2012
632012
The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation
I Hussain, J Fabrègue, L Anderes, S Ousson, F Borlat, V Eligert, S Berger, ...
Journal of Biological Chemistry 288 (4), 2521-2531, 2013
572013
Perturbations of the Straight Transmembrane α-Helical Structure of the Amyloid Precursor Protein Affect its Processing by γ-Secretase
T Lemmin, M Dimitrov, PC Fraering, M Dal Peraro
Journal of Biological Chemistry, jbc. M113. 470781, 2014
512014
Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence
A Revandkar, ML Perciato, A Toso, A Alajati, J Chen, H Gerber, ...
Nature Communications 7, 2016
462016
The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain
S Mosser, JR Alattia, M Dimitrov, A Matz, J Pascual, BL Schneider, ...
Human molecular genetics, ddu449, 2014
352014
Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila
JR Alattia, T Kuraishi, M Dimitrov, I Chang, B Lemaitre, PC Fraering
The FASEB Journal 25 (7), 2287-2295, 2011
342011
Highly efficient production of the Alzheimer's γ‐Secretase integral membrane protease complex by a multi‐gene stable integration approach
JR Alattia, M Matasci, M Dimitrov, L Aeschbach, S Balasubramanian, ...
Biotechnology and bioengineering, 2013
312013
Shedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons
E Borcel, M Palczynska, M Krzisch, M Dimitrov, G Ulrich, N Toni, ...
Scientific Reports 6, 2016
222016
Production of active glycosylation‐deficient γ‐secretase complex for crystallization studies
AR López, M Dimitrov, H Gerber, V Braman, DL Hacker, FM Wurm, ...
Biotechnology and bioengineering 112 (12), 2516-2526, 2015
92015
Generation of monoclonal antibody fragments binding the native γ-secretase complex for use in structural studies
JR Alattia, C Schweizer, M Cacquevel, M Dimitrov, L Aeschbach, ...
Biochemistry 51 (44), 8779-8790, 2012
42012
The Amyloid Precursor Protein Maintains an Ideal&Alpha-Helical Conformation in the Lipid Bilayer
T Lemmin, M Dimitrov, P Fraering, M Dal Peraro
Biophysical Journal 106 (2), 53a, 2014
2014
Pharmacological and biochemical assessment of γ-secretase-mediated APP processing involved in Alzheimer" s disease
M Dimitrov
EPFL, 2014
2014
Intrinsic Transmembrane Flexibility of the Amyloid Precursor Protein Explored by Molecular Simulations
T Lemmin, M Dimitrov, P Fraering, M Dal Peraro
Biophysical Journal 104, 226, 2013
2013
Identical γ-secretase-dependent production of Amyloid Precursor Protein Intracellular Domains from β-and α-carboxy-terminal fragments APP-C99 and APP-C83.
J Houacine, M Dimitrov, SG Hays, L Aeschbach, PC Fraering
The Gamma-Secretase-Mediated Proteolytic Processing of APP C-Terminal …, 2011
2011
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