| Genetic modifiers of risk and age at onset in GBA associated Parkinson’s disease and Lewy body dementia C Blauwendraat, X Reed, L Krohn, K Heilbron, S Bandres-Ciga, M Tan, ... Brain 143 (1), 234-248, 2020 | 180 | 2020 |
| LRRK2 mediates tubulation and vesicle sorting from lysosomes L Bonet-Ponce, A Beilina, CD Williamson, E Lindberg, JH Kluss, ... Science advances 6 (46), eabb2454, 2020 | 152 | 2020 |
| The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling S Saez-Atienzar, L Bonet-Ponce, JR Blesa, FJ Romero, MP Murphy, ... Cell death & disease 5 (8), e1368-e1368, 2014 | 110 | 2014 |
| Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration L Zhang, J Du, S Justus, CW Hsu, L Bonet-Ponce, WH Wu, YT Tsai, ... The Journal of clinical investigation 126 (12), 4659-4673, 2016 | 92 | 2016 |
| The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease S Bandres‐Ciga, S Saez‐Atienzar, L Bonet‐Ponce, K Billingsley, D Vitale, ... Movement Disorders 34 (4), 460-468, 2019 | 78 | 2019 |
| Halting progressive neurodegeneration in advanced retinitis pigmentosa SF Koch, YT Tsai, JK Duong, WH Wu, CW Hsu, WP Wu, L Bonet-Ponce, ... The Journal of clinical investigation 125 (9), 3704-3713, 2015 | 78 | 2015 |
| On the mechanism underlying ethanol-induced mitochondrial dynamic disruption and autophagy response L Bonet-Ponce, S Saez-Atienzar, C da Casa, M Flores-Bellver, JM Barcia, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1852 (7 …, 2015 | 69 | 2015 |
| The Parkinson’s disease protein LRRK2 interacts with the GARP complex to promote retrograde transport to the trans-Golgi network A Beilina, L Bonet-Ponce, R Kumaran, JJ Kordich, M Ishida, A Mamais, ... Cell reports 31 (5), 2020 | 62 | 2020 |
| The genetic architecture of Parkinson disease in Spain: characterizing population‐specific risk, differential haplotype structures, and providing etiologic insight S Bandres‐Ciga, S Ahmed, MS Sabir, C Blauwendraat, ... Movement Disorders 34 (12), 1851-1863, 2019 | 54 | 2019 |
| Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia A Mamais, JH Kluss, L Bonet-Ponce, N Landeck, RG Langston, N Smith, ... PLoS biology 19 (12), e3001480, 2021 | 51 | 2021 |
| Autophagy and mitochondrial alterations in human retinal pigment epithelial cells induced by ethanol: implications of 4-hydroxy-nonenal M Flores-Bellver, L Bonet-Ponce, JM Barcia, JM Garcia-Verdugo, ... Cell death & disease 5 (7), e1328-e1328, 2014 | 50 | 2014 |
| Activating transcription factor 3 (ATF3) protects retinal ganglion cells and promotes functional preservation after optic nerve crush C Kole, B Brommer, N Nakaya, M Sengupta, L Bonet-Ponce, T Zhao, ... Investigative Ophthalmology & Visual Science 61 (2), 31-31, 2020 | 49 | 2020 |
| Rotenone induces the formation of 4-hydroxynonenal aggresomes. Role of ROS-mediated tubulin hyperacetylation and autophagic flux disruption L Bonet-Ponce, S Saez-Atienzar, C Da Casa, J Sancho-Pelluz, JM Barcia, ... Molecular neurobiology 53, 6194-6208, 2016 | 49 | 2016 |
| LRRK2 recruitment, activity, and function in organelles L Bonet‐Ponce, MR Cookson The FEBS journal 289 (22), 6871-6890, 2022 | 47 | 2022 |
| The role of Rab GTPases in the pathobiology of Parkinson’disease L Bonet-Ponce, MR Cookson Current opinion in cell biology 59, 73-80, 2019 | 39 | 2019 |
| Exposure to N-ethyl-N-nitrosourea in adult mice alters structural and functional integrity of neurogenic sites V Capilla-Gonzalez, S Gil-Perotin, A Ferragud, L Bonet-Ponce, ... PLoS One 7 (1), e29891, 2012 | 26 | 2012 |
| Lysosomal positioning regulates Rab10 phosphorylation at LRRK2+ lysosomes JH Kluss, A Beilina, CD Williamson, PA Lewis, MR Cookson, ... Proceedings of the National Academy of Sciences 119 (43), e2205492119, 2022 | 25 | 2022 |
| CYP2E1 in the human retinal pigment epithelium: expression, activity, and induction by ethanol N Martinez-Gil, M Flores-Bellver, S Atienzar-Aroca, D Lopez-Malo, ... Investigative ophthalmology & visual science 56 (11), 6855-6863, 2015 | 22 | 2015 |
| Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitment JH Kluss, L Bonet-Ponce, PA Lewis, MR Cookson Neurobiology of disease 170, 105769, 2022 | 20 | 2022 |
| Bcl-xL-mediated antioxidant function abrogates the disruption of mitochondrial dynamics induced by LRRK2 inhibition S Saez-Atienzar, L Bonet-Ponce, C da Casa, L Perez-Dolz, JR Blesa, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1862 (1), 20-31, 2016 | 17 | 2016 |
Mark CooksonLaboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthAdresse e-mail validée de mail.nih.gov
